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Article: Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation

TitleDistinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation
Authors
Issue Date2005
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
Citation
Developmental Biology, 2005, v. 277 n. 1, p. 255-269 How to Cite?
AbstractMembrane type 1-matrix metalloprotease (MT1-MMP or MMP-14) is a major activator of pro-MMP-2 and is essential for skeletal development. We show here that it is required for branching morphogenesis of the submandibular gland but not the lung. Instead, in the lung, it is essential for postnatal development of alveolar septae. Lung development in Mmp14-/- mice is arrested at the prealveolar stage with compensatory hyperinflation of immature saccules. Mmp2-/- mice lacked comparable defects in the lung and submandibular gland, suggesting that MT1-MMP acts via mechanisms independent of pro-MMP-2 activation. Since the developmental defects in the lung are first manifest around the time of initial vascularization (E16.5), we investigated the behavior of pulmonary endothelial cells from Mmp14+/+ and Mmp14-/- mice. Endothelial cells from lungs of 1-week-old Mmp14-/- mice show reduced migration and formation of three-dimensional structures on Matrigel. Since pulmonary septal development requires capillary growth, the underlying mechanism of pulmonary hypoplasia in Mmp14-/- mice may be defective angiogenesis, supporting a model in which angiogenesis is a critical rate-limiting step for acquisition of pulmonary parenchymal mass. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68337
ISSN
2015 Impact Factor: 3.155
2015 SCImago Journal Rankings: 2.554
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOblander, SAen_HK
dc.contributor.authorZhou, Zen_HK
dc.contributor.authorGálvez, BGen_HK
dc.contributor.authorStarcher, Ben_HK
dc.contributor.authorShannon, JMen_HK
dc.contributor.authorDurbeej, Men_HK
dc.contributor.authorArroyo, AGen_HK
dc.contributor.authorTryggvason, Ken_HK
dc.contributor.authorApte, SSen_HK
dc.date.accessioned2010-09-06T06:03:37Z-
dc.date.available2010-09-06T06:03:37Z-
dc.date.issued2005en_HK
dc.identifier.citationDevelopmental Biology, 2005, v. 277 n. 1, p. 255-269en_HK
dc.identifier.issn0012-1606en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68337-
dc.description.abstractMembrane type 1-matrix metalloprotease (MT1-MMP or MMP-14) is a major activator of pro-MMP-2 and is essential for skeletal development. We show here that it is required for branching morphogenesis of the submandibular gland but not the lung. Instead, in the lung, it is essential for postnatal development of alveolar septae. Lung development in Mmp14-/- mice is arrested at the prealveolar stage with compensatory hyperinflation of immature saccules. Mmp2-/- mice lacked comparable defects in the lung and submandibular gland, suggesting that MT1-MMP acts via mechanisms independent of pro-MMP-2 activation. Since the developmental defects in the lung are first manifest around the time of initial vascularization (E16.5), we investigated the behavior of pulmonary endothelial cells from Mmp14+/+ and Mmp14-/- mice. Endothelial cells from lungs of 1-week-old Mmp14-/- mice show reduced migration and formation of three-dimensional structures on Matrigel. Since pulmonary septal development requires capillary growth, the underlying mechanism of pulmonary hypoplasia in Mmp14-/- mice may be defective angiogenesis, supporting a model in which angiogenesis is a critical rate-limiting step for acquisition of pulmonary parenchymal mass. © 2004 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbioen_HK
dc.relation.ispartofDevelopmental Biologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshEnzyme Activationen_HK
dc.subject.meshEnzyme Precursors - metabolismen_HK
dc.subject.meshLung - embryology - ultrastructureen_HK
dc.subject.meshMatrix Metalloproteinase 14en_HK
dc.subject.meshMatrix Metalloproteinase 2 - metabolismen_HK
dc.subject.meshMatrix Metalloproteinases, Membrane-Associateden_HK
dc.subject.meshMetalloendopeptidases - physiologyen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshMicroscopy, Electron, Scanningen_HK
dc.subject.meshMorphogenesisen_HK
dc.subject.meshSubmandibular Gland - embryology - ultrastructureen_HK
dc.titleDistinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-1606&volume=277&spage=255&epage=269&date=2005&atitle=Distinctive+Functions+Of+Membrane+Type+1+Matrix-metalloprotease+(mt1-mmp+Or+Mmp-14)+In+Lung+And+Submandibular+Gland+Development+Are+Independent+Of+Its+Role+In+Pro-mmp-2+Activationen_HK
dc.identifier.emailZhou, Z:zhongjun@hkucc.hku.hken_HK
dc.identifier.authorityZhou, Z=rp00503en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ydbio.2004.09.033en_HK
dc.identifier.pmid15572153-
dc.identifier.scopuseid_2-s2.0-9644253129en_HK
dc.identifier.hkuros100106en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9644253129&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume277en_HK
dc.identifier.issue1en_HK
dc.identifier.spage255en_HK
dc.identifier.epage269en_HK
dc.identifier.isiWOS:000225741200019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOblander, SA=8767540800en_HK
dc.identifier.scopusauthoridZhou, Z=8631856300en_HK
dc.identifier.scopusauthoridGálvez, BG=6603185270en_HK
dc.identifier.scopusauthoridStarcher, B=7006414972en_HK
dc.identifier.scopusauthoridShannon, JM=7203029644en_HK
dc.identifier.scopusauthoridDurbeej, M=6603950044en_HK
dc.identifier.scopusauthoridArroyo, AG=7005609208en_HK
dc.identifier.scopusauthoridTryggvason, K=7102025185en_HK
dc.identifier.scopusauthoridApte, SS=7101907193en_HK
dc.identifier.citeulike9830277-

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