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Article: The APC regulator CDH1 is essential for the progression of embryonic cell cycles in Xenopus

TitleThe APC regulator CDH1 is essential for the progression of embryonic cell cycles in Xenopus
Authors
KeywordsAnaphase-promoting complex (APC)
CDH1
Cell cycle arrest
Cyclin degradation
Xenopus embryonic cell cycles
Issue Date2002
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2002, v. 294 n. 1, p. 120-126 How to Cite?
AbstractThe orderly progression of cell cycle depends on timely destruction of key regulators through ubiquitin-mediated proteolysis. The anaphase-promoting complex (APC) is a major component of this degradation machinery and its activation is regulated by CDC20 and CDH1. We demonstrate here that CDH1 mRNA is ubiquitously expressed in Xenopus embryos of all developmental stages. Loss of CDH1 function during early embryonic cell cycles leads to an immediate and prolonged arrest with low cyclin-dependent kinase activity. In contrast, ectopic overexpression of CDH1 induces cell cycle arrest during the first G1 phase at the midblastula transition. CDH1-dependent degradation of cyclin A is likely involved in this G1 arrest. Our findings establish the essential roles of CDH1 in embryonic cell cycles. © 2002 Elsevier Science (USA). All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/68295
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorChing, YPen_HK
dc.contributor.authorNg, RWMen_HK
dc.contributor.authorJin, DYen_HK
dc.date.accessioned2010-09-06T06:03:13Z-
dc.date.available2010-09-06T06:03:13Z-
dc.date.issued2002en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2002, v. 294 n. 1, p. 120-126en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/68295-
dc.description.abstractThe orderly progression of cell cycle depends on timely destruction of key regulators through ubiquitin-mediated proteolysis. The anaphase-promoting complex (APC) is a major component of this degradation machinery and its activation is regulated by CDC20 and CDH1. We demonstrate here that CDH1 mRNA is ubiquitously expressed in Xenopus embryos of all developmental stages. Loss of CDH1 function during early embryonic cell cycles leads to an immediate and prolonged arrest with low cyclin-dependent kinase activity. In contrast, ectopic overexpression of CDH1 induces cell cycle arrest during the first G1 phase at the midblastula transition. CDH1-dependent degradation of cyclin A is likely involved in this G1 arrest. Our findings establish the essential roles of CDH1 in embryonic cell cycles. © 2002 Elsevier Science (USA). All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectAnaphase-promoting complex (APC)en_HK
dc.subjectCDH1en_HK
dc.subjectCell cycle arresten_HK
dc.subjectCyclin degradationen_HK
dc.subjectXenopus embryonic cell cyclesen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Cycle - physiologyen_HK
dc.subject.meshCell Cycle Proteinsen_HK
dc.subject.meshCyclin A - metabolismen_HK
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFungal Proteins - genetics - physiologyen_HK
dc.subject.meshG1 Phaseen_HK
dc.subject.meshLigases - metabolismen_HK
dc.subject.meshProteins - genetics - physiologyen_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshSaccharomyces cerevisiae Proteinsen_HK
dc.subject.meshUbiquitin-Protein Ligase Complexesen_HK
dc.subject.meshXenopus laevis - embryologyen_HK
dc.titleThe APC regulator CDH1 is essential for the progression of embryonic cell cycles in Xenopusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-291X&volume=294&spage=120&epage=6&date=2002&atitle=The+APC+regulator+CDH1+is+essential+for+the+progression+of+embryonic+cell+cycles+in+Xenopusen_HK
dc.identifier.emailChing, YP:ypching@hku.hken_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.authorityChing, YP=rp00469en_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0006-291X(02)00447-3en_HK
dc.identifier.pmid12054750en_HK
dc.identifier.scopuseid_2-s2.0-0036295345en_HK
dc.identifier.hkuros69115en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036295345&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume294en_HK
dc.identifier.issue1en_HK
dc.identifier.spage120en_HK
dc.identifier.epage126en_HK
dc.identifier.isiWOS:000176234500020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhou, Y=7405366890en_HK
dc.identifier.scopusauthoridChing, YP=7005431277en_HK
dc.identifier.scopusauthoridNg, RWM=7102153861en_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK

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