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Article: Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population

TitleAssociation of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population
Authors
KeywordsDegenerative disc disease
Intervertebral disc herniation
Magnetic resonance imaging
Taq I
Vitamin D receptor
Issue Date2006
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.com
Citation
Spine, 2006, v. 31 n. 10, p. 1143-1148 How to Cite?
AbstractStudy Design. Large scale, case-control study. Objective. To assess the effect of the Taq I alleles in vitamin D receptor on the risk of developing degenerative disc disease in a Southern Chinese population. Summary of Background Data. Previous studies in Finns and Japanese suggest that the Taq I polymorphism of vitamin D receptor is associated with the development of degenerative disc disease in the lumbar spine. However, sample sizes were small, and the results need to be confirmed in other populations. Method. Lumbar degenerative disc disease was defined by magnetic resonance imaging (MRI) on 804 Southern Chinese volunteers between 18 and 55 years of age. Restriction enzyme digestion of polymerase chain reaction products was used to analyze the Taq I alleles. The resulting genotypes were correlated with the presence of lumbar disc degeneration and bulge on MRI. Results. Using logistic regression analysis and adjusting for age and sex, the t allele of Taq I in vitamin D receptor gene was significantly associated with degenerative disc disease, with an odds ratio (OR) of 2.61 (95% confidence interval [CI] 1.15-5.90, P = 0.041). Further subgroup analysis showed that in individuals younger than 40 years, the OR was even higher, at 5.97 (95% CI 1.69-21.15, P = 0.002). Similarly, disc bulge was significantly associated with fallele (OR = 7.17, 95% CI 1.43-36.01, P = 0.001) in individuals younger than 40 years. Anular tears and the Schmorl nodes were not associated with the f allele of Taq I polymorphism. Conclusion. To our knowledge, this is the largest scale genetics study to date using MRI to define precisely degenerative disc disease in the Southern Chinese population. We showed that the f allele of vitamin D receptor Taq I is associated with a high risk of degenerative disc disease and disc bulge developing, especially in individuals younger than 40 years. ©2006, Lippincott Williams & Wilkins, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/68129
ISSN
2015 Impact Factor: 2.439
2015 SCImago Journal Rankings: 1.459
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorKarppinen, Jen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorJim, JJTen_HK
dc.contributor.authorYip, SPen_HK
dc.contributor.authorOtt, Jen_HK
dc.contributor.authorWong, KKen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorCheah, KSEen_HK
dc.contributor.authorLeong, JCYen_HK
dc.contributor.authorSong, YQen_HK
dc.date.accessioned2010-09-06T06:01:38Z-
dc.date.available2010-09-06T06:01:38Z-
dc.date.issued2006en_HK
dc.identifier.citationSpine, 2006, v. 31 n. 10, p. 1143-1148en_HK
dc.identifier.issn0362-2436en_HK
dc.identifier.urihttp://hdl.handle.net/10722/68129-
dc.description.abstractStudy Design. Large scale, case-control study. Objective. To assess the effect of the Taq I alleles in vitamin D receptor on the risk of developing degenerative disc disease in a Southern Chinese population. Summary of Background Data. Previous studies in Finns and Japanese suggest that the Taq I polymorphism of vitamin D receptor is associated with the development of degenerative disc disease in the lumbar spine. However, sample sizes were small, and the results need to be confirmed in other populations. Method. Lumbar degenerative disc disease was defined by magnetic resonance imaging (MRI) on 804 Southern Chinese volunteers between 18 and 55 years of age. Restriction enzyme digestion of polymerase chain reaction products was used to analyze the Taq I alleles. The resulting genotypes were correlated with the presence of lumbar disc degeneration and bulge on MRI. Results. Using logistic regression analysis and adjusting for age and sex, the t allele of Taq I in vitamin D receptor gene was significantly associated with degenerative disc disease, with an odds ratio (OR) of 2.61 (95% confidence interval [CI] 1.15-5.90, P = 0.041). Further subgroup analysis showed that in individuals younger than 40 years, the OR was even higher, at 5.97 (95% CI 1.69-21.15, P = 0.002). Similarly, disc bulge was significantly associated with fallele (OR = 7.17, 95% CI 1.43-36.01, P = 0.001) in individuals younger than 40 years. Anular tears and the Schmorl nodes were not associated with the f allele of Taq I polymorphism. Conclusion. To our knowledge, this is the largest scale genetics study to date using MRI to define precisely degenerative disc disease in the Southern Chinese population. We showed that the f allele of vitamin D receptor Taq I is associated with a high risk of degenerative disc disease and disc bulge developing, especially in individuals younger than 40 years. ©2006, Lippincott Williams & Wilkins, Inc.en_HK
dc.languageengen_HK
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.comen_HK
dc.relation.ispartofSpineen_HK
dc.subjectDegenerative disc diseaseen_HK
dc.subjectIntervertebral disc herniationen_HK
dc.subjectMagnetic resonance imagingen_HK
dc.subjectTaq Ien_HK
dc.subjectVitamin D receptoren_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenetic Predisposition to Diseaseen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntervertebral Disc Displacement - epidemiology - geneticsen_HK
dc.subject.meshLumbar Vertebrae - pathology - radiographyen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_HK
dc.subject.meshReceptors, Calcitriol - geneticsen_HK
dc.subject.meshTaq Polymerase - geneticsen_HK
dc.titleAssociation of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0887-9869&volume=31&issue=10&spage=1143&epage=1148&date=2006&atitle=Association+of+the+Taq+I+allele+in+vitamin+D+receptor+with+degenerative+disc+disease+and+disc+bulge+in+a+Chinese+populationen_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailChan, D: chand@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_HK
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hken_HK
dc.identifier.emailSong, YQ: songy@hku.hken_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.brs.0000216530.41838.d3en_HK
dc.identifier.pmid16648751-
dc.identifier.scopuseid_2-s2.0-33646569116en_HK
dc.identifier.hkuros133433en_HK
dc.identifier.hkuros128299-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646569116&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1143en_HK
dc.identifier.epage1148en_HK
dc.identifier.isiWOS:000237362100013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridKarppinen, J=7004560479en_HK
dc.identifier.scopusauthoridChen, Y=13409429100en_HK
dc.identifier.scopusauthoridJim, JJT=10341020300en_HK
dc.identifier.scopusauthoridYip, SP=7102133673en_HK
dc.identifier.scopusauthoridOtt, J=7202757548en_HK
dc.identifier.scopusauthoridWong, KK=35222708000en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK

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