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Article: Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer

TitleDownregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer
Authors
Issue Date2009
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 2009, v. 124 n. 7, p. 1587-1593 How to Cite?
AbstractDeletion of 19p13 is one of the most frequent genetic changes in gastric carcinoma (GC), implying the existence of a tumor suppressor gene (TSG) that plays an important role in GC development. To identify the candidate TSG at 19p, array-comparative genomic hybridization (CGH) was applied to study DNA copy- number changes on chromosomes 3, 5p, 13, 16q and 19. The result showed that gains of 16q21, 19q13.1, 5p15.1 and 3q26.31, and losses of 3p21.32, 3p22.2, 19q13.33 and 19p13.3, were frequently detected by array-CGH. One candidate TSG, ZIP kinase (ZIPK), at 19p13.3 was further characterized by immunohistochemistry using a tissue microarray containing 172 primary GCs. Downregulation of ZIPK was detected in 111/162 informative GCs, which was significantly associated with invasion, metastasis and poorer prognosis of GC. To investigate the association of the downregulation of ZIPK with apoptosis, apoptosis assay (TUNEL) was used to compare the apoptotic index between GCs with normal expression and downregulation of ZIPK. TUNEL assay showed that the apoptotic index in GCs with normal ZIPK expression was significantly higher than that in GCs with downregulation of ZIPK (p < 0.001), indicating that ZIPK plays an important pro-apoptotic role in GC. Taken together, we demonstrated here that ZIPK is a tumor suppresser gene and plays an important role in GC development through its pro-apoptotic function. Downregulation of ZIPK can be used to evaluate tumor invasiveness, metastasis and to predict survival of GC. © 2008 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/58599
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
Funding AgencyGrant Number
Still Yat-Sen University85000-3171311
Major State Basic Research Program of China2006CB910104
National Natural Science Foundation of China30772475
30700820
30672053
Funding Information:

Grant sponsor: Still Yat-Sen University (Hundred Talents Program) Grant number: 85000-3171311. Grant sponsor: Major State Basic Research Program of China; Grant number: 2006CB910104. Grant sponsor: National Natural Science Foundation of China; Grant numbers: 30772475, 30700820, 30672053.

References

 

DC FieldValueLanguage
dc.contributor.authorBi, Jen_HK
dc.contributor.authorLau, SHen_HK
dc.contributor.authorHu, Len_HK
dc.contributor.authorRao, HLen_HK
dc.contributor.authorLiu, HBen_HK
dc.contributor.authorZhan, WHen_HK
dc.contributor.authorChen, Gen_HK
dc.contributor.authorWen, JMen_HK
dc.contributor.authorWang, Qen_HK
dc.contributor.authorLi, Ben_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2010-05-31T03:33:14Z-
dc.date.available2010-05-31T03:33:14Z-
dc.date.issued2009en_HK
dc.identifier.citationInternational Journal Of Cancer, 2009, v. 124 n. 7, p. 1587-1593en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58599-
dc.description.abstractDeletion of 19p13 is one of the most frequent genetic changes in gastric carcinoma (GC), implying the existence of a tumor suppressor gene (TSG) that plays an important role in GC development. To identify the candidate TSG at 19p, array-comparative genomic hybridization (CGH) was applied to study DNA copy- number changes on chromosomes 3, 5p, 13, 16q and 19. The result showed that gains of 16q21, 19q13.1, 5p15.1 and 3q26.31, and losses of 3p21.32, 3p22.2, 19q13.33 and 19p13.3, were frequently detected by array-CGH. One candidate TSG, ZIP kinase (ZIPK), at 19p13.3 was further characterized by immunohistochemistry using a tissue microarray containing 172 primary GCs. Downregulation of ZIPK was detected in 111/162 informative GCs, which was significantly associated with invasion, metastasis and poorer prognosis of GC. To investigate the association of the downregulation of ZIPK with apoptosis, apoptosis assay (TUNEL) was used to compare the apoptotic index between GCs with normal expression and downregulation of ZIPK. TUNEL assay showed that the apoptotic index in GCs with normal ZIPK expression was significantly higher than that in GCs with downregulation of ZIPK (p < 0.001), indicating that ZIPK plays an important pro-apoptotic role in GC. Taken together, we demonstrated here that ZIPK is a tumor suppresser gene and plays an important role in GC development through its pro-apoptotic function. Downregulation of ZIPK can be used to evaluate tumor invasiveness, metastasis and to predict survival of GC. © 2008 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshApoptosis - physiologyen_HK
dc.subject.meshApoptosis Regulatory Proteins - genetics - metabolismen_HK
dc.subject.meshCalcium-Calmodulin-Dependent Protein Kinases - genetics - metabolismen_HK
dc.subject.meshComparative Genomic Hybridizationen_HK
dc.subject.meshDown-Regulationen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIn Situ Nick-End Labelingen_HK
dc.subject.meshKaplan-Meier Estimateen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Invasiveness - genetics - pathologyen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshStomach Neoplasms - enzymology - genetics - pathologyen_HK
dc.subject.meshTissue Array Analysisen_HK
dc.subject.meshTumor Markers, Biological - analysisen_HK
dc.titleDownregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-7136&volume=124&spage=1587&epage=1593&date=2009&atitle=Downregulation+of+ZIP+Kinase+is+associated+with+tumor+invasion,+metastasis+and+poor+prognosis+in+gastric+canceren_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ijc.24164en_HK
dc.identifier.pmid19117059-
dc.identifier.scopuseid_2-s2.0-61449096746en_HK
dc.identifier.hkuros156540en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61449096746&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume124en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1587en_HK
dc.identifier.epage1593en_HK
dc.identifier.isiWOS:000263804900011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBi, J=7103093361en_HK
dc.identifier.scopusauthoridLau, SH=7401596190en_HK
dc.identifier.scopusauthoridHu, L=34770075600en_HK
dc.identifier.scopusauthoridRao, HL=35277843000en_HK
dc.identifier.scopusauthoridLiu, HB=27171509500en_HK
dc.identifier.scopusauthoridZhan, WH=7102238667en_HK
dc.identifier.scopusauthoridChen, G=35277129100en_HK
dc.identifier.scopusauthoridWen, JM=7402701931en_HK
dc.identifier.scopusauthoridWang, Q=35277527500en_HK
dc.identifier.scopusauthoridLi, B=26663761000en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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