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Article: Chloroform extract of cigarette smoke induces proliferation of human esophageal squamous-cell carcinoma cells: Modulation by β-adrenoceptors

TitleChloroform extract of cigarette smoke induces proliferation of human esophageal squamous-cell carcinoma cells: Modulation by β-adrenoceptors
Authors
Keywordsβ-adrenoceptors
Cigarette smoke extract
Cyclo-oxygenase-2
Esophageal cancer
Issue Date2009
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/01480545.asp
Citation
Drug And Chemical Toxicology, 2009, v. 32 n. 3, p. 175-181 How to Cite?
AbstractThe present study aimed to delineate the actions of cigarette smoke extracts on esophageal squamous-cell carcinoma cell growth in vitro. Both chloroform- and ethanol-extracts from cigarette smoke stimulated human esophageal squamous carcinoma EC109 cell proliferation. Chloroform- and ethanol-extracts also upregulated β-adrenoceptors expression in EC109 cells. Cyclo-oxygenase-2 (COX-2) expression was increased by chloroform-extract. The stimulatory actions of chloroform-extract on cell proliferation and COX-2 expression were abolished by β1- and β2-adrenoceptor selective antagonists, implicating that COX-2 was downstream to the β-adrenoceptors. Collectively, the promoting action of chloroform-extract from cigarette smoke on esophageal squamous-cell carcinoma cell proliferation is β-adrenoceptor- and COX-2-dependent. © 2009 Informa UK Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/58411
ISSN
2015 Impact Factor: 1.653
2015 SCImago Journal Rankings: 0.492
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research7499/05M
Chinese University of Hong Kong
Funding Information:

The study was supported by the Hong Kong Research Grants Council (CUHK 7499/05M) and the Direct Grant from the Chinese University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorLi, Pen_HK
dc.contributor.authorWu, WKKen_HK
dc.contributor.authorWong, HPSen_HK
dc.contributor.authorZhang, STen_HK
dc.contributor.authorYu, Len_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-05-31T03:29:49Z-
dc.date.available2010-05-31T03:29:49Z-
dc.date.issued2009en_HK
dc.identifier.citationDrug And Chemical Toxicology, 2009, v. 32 n. 3, p. 175-181en_HK
dc.identifier.issn0148-0545en_HK
dc.identifier.urihttp://hdl.handle.net/10722/58411-
dc.description.abstractThe present study aimed to delineate the actions of cigarette smoke extracts on esophageal squamous-cell carcinoma cell growth in vitro. Both chloroform- and ethanol-extracts from cigarette smoke stimulated human esophageal squamous carcinoma EC109 cell proliferation. Chloroform- and ethanol-extracts also upregulated β-adrenoceptors expression in EC109 cells. Cyclo-oxygenase-2 (COX-2) expression was increased by chloroform-extract. The stimulatory actions of chloroform-extract on cell proliferation and COX-2 expression were abolished by β1- and β2-adrenoceptor selective antagonists, implicating that COX-2 was downstream to the β-adrenoceptors. Collectively, the promoting action of chloroform-extract from cigarette smoke on esophageal squamous-cell carcinoma cell proliferation is β-adrenoceptor- and COX-2-dependent. © 2009 Informa UK Ltd.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/01480545.aspen_HK
dc.relation.ispartofDrug and Chemical Toxicologyen_HK
dc.rightsDrug and Chemical Toxicology. Copyright © Informa Healthcare.en_HK
dc.subjectβ-adrenoceptorsen_HK
dc.subjectCigarette smoke extracten_HK
dc.subjectCyclo-oxygenase-2en_HK
dc.subjectEsophageal canceren_HK
dc.titleChloroform extract of cigarette smoke induces proliferation of human esophageal squamous-cell carcinoma cells: Modulation by β-adrenoceptorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0148-0545&volume=32&spage=175&epage=181&date=2009&atitle=Chloroform+extract+of+cigarette+smoke+induces+proliferation+of+human+esophageal+squamous-cell+carcinoma+cells:+modulation+by+beta-adrenoceptorsen_HK
dc.identifier.emailWong, HPS:hpswong@hkusua.hku.hken_HK
dc.identifier.authorityWong, HPS=rp00808en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/01480540902875253en_HK
dc.identifier.scopuseid_2-s2.0-70349902684en_HK
dc.identifier.hkuros157303en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349902684&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue3en_HK
dc.identifier.spage175en_HK
dc.identifier.epage181en_HK
dc.identifier.isiWOS:000268575400001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, P=26643192100en_HK
dc.identifier.scopusauthoridWu, WKK=18345422600en_HK
dc.identifier.scopusauthoridWong, HPS=8644138100en_HK
dc.identifier.scopusauthoridZhang, ST=22935976000en_HK
dc.identifier.scopusauthoridYu, L=16314581700en_HK
dc.identifier.scopusauthoridCho, CH=14067000400en_HK

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