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Article: Brain MRI abnormalities in schizophrenia: Same genes or same environment?

TitleBrain MRI abnormalities in schizophrenia: Same genes or same environment?
Authors
Issue Date2005
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2005, v. 35 n. 10, p. 1399-1409 How to Cite?
AbstractBackground. Structural brain volume abnormalities are among the most extensively studied endophenotypes in schizophrenia. Bivariate genetic model fitting (adjusted to account for selection) was used to quantify the genetic relationship between schizophrenia and brain volumes and to estimate the heritability of these volumes. Method. We demonstrated by simulation that the adjusted genetic model produced unbiased estimates for endophenotype heritability and the genetic and environmental correlations. The model was applied to brain volumes (whole brain, hippocampus, third and lateral ventricles) in a sample of 14 monozygotic (MZ) twin pairs concordant for schizophrenia, 10 MZ discordant pairs, 17 MZ control pairs, 22 discordant sibling pairs, three concordant sibling pairs, and 114 healthy control subjects. Results. Whole brain showed a substantial heritability (88%) and lateral ventricles substantial common environmental effects (67%). Whole brain showed a significant genetic correlation with schizophrenia, whereas lateral ventricles showed a significant individual specific correlation with schizophrenia. There were significant familial effects for hippocampus and third ventricle, but the analyses could not resolve whether these were genetic or environmental in origin (around 30% each). Conclusions. Using genetic model fitting on twin and sibling data we have demonstrated differential sources of covariation between schizophrenia and brain volumes, genetic in the case of whole brain volume and individual specific environment in the case of lateral ventricles. © 2005 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/45305
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRijsdijk, FVen_HK
dc.contributor.authorvan Haren, NEMen_HK
dc.contributor.authorPicchioni, MMen_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorPol, HEHen_HK
dc.contributor.authorKahn, RSen_HK
dc.contributor.authorMurray, Ren_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2007-10-30T06:22:21Z-
dc.date.available2007-10-30T06:22:21Z-
dc.date.issued2005en_HK
dc.identifier.citationPsychological Medicine, 2005, v. 35 n. 10, p. 1399-1409en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45305-
dc.description.abstractBackground. Structural brain volume abnormalities are among the most extensively studied endophenotypes in schizophrenia. Bivariate genetic model fitting (adjusted to account for selection) was used to quantify the genetic relationship between schizophrenia and brain volumes and to estimate the heritability of these volumes. Method. We demonstrated by simulation that the adjusted genetic model produced unbiased estimates for endophenotype heritability and the genetic and environmental correlations. The model was applied to brain volumes (whole brain, hippocampus, third and lateral ventricles) in a sample of 14 monozygotic (MZ) twin pairs concordant for schizophrenia, 10 MZ discordant pairs, 17 MZ control pairs, 22 discordant sibling pairs, three concordant sibling pairs, and 114 healthy control subjects. Results. Whole brain showed a substantial heritability (88%) and lateral ventricles substantial common environmental effects (67%). Whole brain showed a significant genetic correlation with schizophrenia, whereas lateral ventricles showed a significant individual specific correlation with schizophrenia. There were significant familial effects for hippocampus and third ventricle, but the analyses could not resolve whether these were genetic or environmental in origin (around 30% each). Conclusions. Using genetic model fitting on twin and sibling data we have demonstrated differential sources of covariation between schizophrenia and brain volumes, genetic in the case of whole brain volume and individual specific environment in the case of lateral ventricles. © 2005 Cambridge University Press.en_HK
dc.format.extent155272 bytes-
dc.format.extent593678 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBrain - abnormalitiesen_HK
dc.subject.meshEnvironmenten_HK
dc.subject.meshSchizophrenia - diagnosis - geneticsen_HK
dc.subject.meshCerebral Ventricles - abnormalitiesen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.titleBrain MRI abnormalities in schizophrenia: Same genes or same environment?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0033-2917&volume=35&issue=10&spage=1399&epage=1409&date=2005&atitle=Brain+MRI+abnormalities+in+schizophrenia:+same+genes+or+same+environment?en_HK
dc.identifier.emailToulopoulou, T: timothea@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1017/S0033291705005167en_HK
dc.identifier.pmid16164764-
dc.identifier.scopuseid_2-s2.0-26444432300en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26444432300&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1399en_HK
dc.identifier.epage1409en_HK
dc.identifier.isiWOS:000232589000002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridRijsdijk, FV=6701830835en_HK
dc.identifier.scopusauthoridvan Haren, NEM=6603501057en_HK
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridPol, HEH=6602660664en_HK
dc.identifier.scopusauthoridKahn, RS=7201463706en_HK
dc.identifier.scopusauthoridMurray, R=35406239400en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK

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