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Article: Cloning of human genes encoding novel G protein-coupled receptors

TitleCloning of human genes encoding novel G protein-coupled receptors
Authors
Issue Date1994
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 1994, v. 23 n. 3, p. 609-618 How to Cite?
AbstractWe report the isolation and characterization of several novel human genes encoding G protein-coupled receptors. Each of the receptors contained the familiar seven transmembrane topography and most closely resembled peptide binding receptors. Gene GPR1 encoded a receptor protein that is intronless in the coding region and that shared identity (43% in the transmembrane regions) with the opioid receptors. Northern blot analysis revealed that GPR1 transcripts were expressed in the human hippocampus, and the gene was localized to chromosome 15q21.6. Gene GPR2 encoded a protein that most closely resembled an interleukin-8 receptor (51% in the transmembrane regions), and this gene, not expressed in the six brain regions examined, was localized to chromosome 17q21.1-q21.3. A third gene, GPR3, showed identity (56% in the transmembrane regions) with a previously characterized cDNA clone from rat and was localized to chromosome 1p35-p36.1.
Persistent Identifierhttp://hdl.handle.net/10722/44279
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMarchese, Aen_HK
dc.contributor.authorDocherty, JMen_HK
dc.contributor.authorNguyen, Ten_HK
dc.contributor.authorHeiber, Men_HK
dc.contributor.authorCheng, Ren_HK
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorShi, Xen_HK
dc.contributor.authorGeorge, SRen_HK
dc.contributor.authorO'Dowd, BFen_HK
dc.date.accessioned2007-09-12T03:50:31Z-
dc.date.available2007-09-12T03:50:31Z-
dc.date.issued1994en_HK
dc.identifier.citationGenomics, 1994, v. 23 n. 3, p. 609-618en_HK
dc.identifier.issn0888-7543en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44279-
dc.description.abstractWe report the isolation and characterization of several novel human genes encoding G protein-coupled receptors. Each of the receptors contained the familiar seven transmembrane topography and most closely resembled peptide binding receptors. Gene GPR1 encoded a receptor protein that is intronless in the coding region and that shared identity (43% in the transmembrane regions) with the opioid receptors. Northern blot analysis revealed that GPR1 transcripts were expressed in the human hippocampus, and the gene was localized to chromosome 15q21.6. Gene GPR2 encoded a protein that most closely resembled an interleukin-8 receptor (51% in the transmembrane regions), and this gene, not expressed in the six brain regions examined, was localized to chromosome 17q21.1-q21.3. A third gene, GPR3, showed identity (56% in the transmembrane regions) with a previously characterized cDNA clone from rat and was localized to chromosome 1p35-p36.1.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_HK
dc.relation.ispartofGenomicsen_HK
dc.subject.meshBrain - metabolismen_HK
dc.subject.meshChromosomes, human, pair 1en_HK
dc.subject.meshChromosomes, human, pair 15en_HK
dc.subject.meshChromosomes, human, pair 17en_HK
dc.subject.meshGtp-binding proteins - geneticsen_HK
dc.titleCloning of human genes encoding novel G protein-coupled receptorsen_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1006/geno.1994.1549en_HK
dc.identifier.pmid7851889-
dc.identifier.scopuseid_2-s2.0-0028034955en_HK
dc.identifier.volume23en_HK
dc.identifier.issue3en_HK
dc.identifier.spage609en_HK
dc.identifier.epage618en_HK
dc.identifier.isiWOS:A1994PN75300013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMarchese, A=7005075855en_HK
dc.identifier.scopusauthoridDocherty, JM=7102949746en_HK
dc.identifier.scopusauthoridNguyen, T=26667936100en_HK
dc.identifier.scopusauthoridHeiber, M=6507950665en_HK
dc.identifier.scopusauthoridCheng, R=7201955297en_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridShi, X=7402953863en_HK
dc.identifier.scopusauthoridGeorge, SR=35429392100en_HK
dc.identifier.scopusauthoridO'Dowd, BF=7102778005en_HK

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