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Article: Interaction of a lens cell transcription factor with the proximal domain of the mouse γF-crystallin promoter

TitleInteraction of a lens cell transcription factor with the proximal domain of the mouse γF-crystallin promoter
Authors
Issue Date1991
PublisherAmerican Society for Microbiology.
Citation
Molecular And Cellular Biology, 1991, v. 11 n. 3, p. 1531-1537 How to Cite?
AbstractThe elements regulating lens-specific expression of the mouse γF-crystallin gene were examined. Here we show that mouse γF-crystallin sequences -67 to +45 contain a low basal level of lens-specific promoter activity and that sequences -67 to -25, which are highly conserved among different γ-crystallin genes, are able to function as a strong transcriptional activator when duplicated and placed upstream of the TATA box. We also show that nuclear factors from lens and nonlens cells are able to form different complexes with sequences centered at -46 to -36 and demonstrate that binding of the factor from lens cells correlates with lens-specific promoter activity of the mouse γF-crystallin gene.
Persistent Identifierhttp://hdl.handle.net/10722/44243
ISSN
2015 Impact Factor: 4.427
2015 SCImago Journal Rankings: 3.806
Other Identifiers
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Qen_HK
dc.contributor.authorTini, Men_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorBreitman, MLen_HK
dc.date.accessioned2007-09-12T03:49:44Z-
dc.date.available2007-09-12T03:49:44Z-
dc.date.issued1991en_HK
dc.identifierhttp://mcb.asm.org/cgi/reprint/11/3/1531.pdfen_HK
dc.identifier.citationMolecular And Cellular Biology, 1991, v. 11 n. 3, p. 1531-1537en_HK
dc.identifier.issn0270-7306en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44243-
dc.description.abstractThe elements regulating lens-specific expression of the mouse γF-crystallin gene were examined. Here we show that mouse γF-crystallin sequences -67 to +45 contain a low basal level of lens-specific promoter activity and that sequences -67 to -25, which are highly conserved among different γ-crystallin genes, are able to function as a strong transcriptional activator when duplicated and placed upstream of the TATA box. We also show that nuclear factors from lens and nonlens cells are able to form different complexes with sequences centered at -46 to -36 and demonstrate that binding of the factor from lens cells correlates with lens-specific promoter activity of the mouse γF-crystallin gene.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology.en_HK
dc.relation.ispartofMolecular and Cellular Biologyen_HK
dc.rightsCopyright © American Society for Microbiology, Molecular and cellular biology, 1991, v. 11 n. 3, p. 1531-1537en_HK
dc.subject.meshBiology - biochemistry biology - cytology and histologyen_HK
dc.subject.meshDna mutational analysisen_HK
dc.subject.meshGene expression regulationen_HK
dc.subject.meshLens, crystalline - physiologyen_HK
dc.subject.meshOligonucleotides - chemistryen_HK
dc.titleInteraction of a lens cell transcription factor with the proximal domain of the mouse γF-crystallin promoteren_HK
dc.typeArticleen_HK
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_OA_fulltexten_HK
dc.identifier.pmid1996107-
dc.identifier.pmcidPMC369438-
dc.identifier.scopuseid_2-s2.0-0026071413en_HK
dc.identifier.volume11en_HK
dc.identifier.issue3en_HK
dc.identifier.spage1531en_HK
dc.identifier.epage1537en_HK
dc.identifier.isiWOS:A1991EZ33100037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, Q=7406296355en_HK
dc.identifier.scopusauthoridTini, M=55409977200en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridBreitman, ML=7005448008en_HK

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