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Article: Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice

TitleIntradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
Authors
KUWENTRAI, CYu, JRONG, LZhang, BZHu, YFGONG, HRDou, YDeng, JHuang, JDXu, C
KeywordsCOVID‐19
SARS‐CoV‐2
intradermal delivery
microneedle
receptor‐binding domain
Issue Date2021
PublisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2380-6761
Citation
Bioengineering & Translational Medicine, 2021, v. 6 n. 1, p. article no. e10202 How to Cite?
DOI: http://dx.doi.org/10.1002/btm2.10202
AbstractThe S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein contains an immunogenic receptor-binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S-RBD vaccine using a dissolvable microneedle skin patch can induce both significant B-cell and significant T-cell responses against S-RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.
Persistent Identifierhttp://hdl.handle.net/10722/305726
ISSN
2380-6761
2021 Impact Factor: 10.684
PubMed Central ID
PMC7744900
ISI Accession Number ID
WOS:000597651600001

 

DC FieldValueLanguage
dc.contributor.authorKUWENTRAI, C-
dc.contributor.authorYu, J-
dc.contributor.authorRONG, L-
dc.contributor.authorZhang, BZ-
dc.contributor.authorHu, YF-
dc.contributor.authorGONG, HR-
dc.contributor.authorDou, Y-
dc.contributor.authorDeng, J-
dc.contributor.authorHuang, JD-
dc.contributor.authorXu, C-
dc.date.accessioned2021-10-20T10:13:28Z-
dc.date.available2021-10-20T10:13:28Z-
dc.date.issued2021-
dc.identifier.citationBioengineering & Translational Medicine, 2021, v. 6 n. 1, p. article no. e10202-
dc.identifier.issn2380-6761-
dc.identifier.urihttp://hdl.handle.net/10722/305726-
dc.description.abstractThe S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein contains an immunogenic receptor-binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S-RBD vaccine using a dissolvable microneedle skin patch can induce both significant B-cell and significant T-cell responses against S-RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2380-6761-
dc.relation.ispartofBioengineering & Translational Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCOVID‐19-
dc.subjectSARS‐CoV‐2-
dc.subjectintradermal delivery-
dc.subjectmicroneedle-
dc.subjectreceptor‐binding domain-
dc.titleIntradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice-
dc.typeArticle-
dc.identifier.emailDou, Y: douying@hku.hk-
dc.identifier.emailHuang, JD: jdhuang@hku.hk-
dc.identifier.authorityHuang, JD=rp00451-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/btm2.10202-
dc.identifier.pmid33349797-
dc.identifier.pmcidPMC7744900-
dc.identifier.scopuseid_2-s2.0-85097382488-
dc.identifier.hkuros326822-
dc.identifier.volume6-
dc.identifier.issue1-
dc.identifier.spagearticle no. e10202-
dc.identifier.epagearticle no. e10202-
dc.identifier.isiWOS:000597651600001-
dc.publisher.placeUnited States-

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