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- Publisher Website: 10.1186/s13020-021-00472-9
- Scopus: eid_2-s2.0-85111380192
- PMID: 34315520
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Article: The toxicology and detoxification of Aconitum: traditional and modern views
Title | The toxicology and detoxification of Aconitum: traditional and modern views |
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Authors | |
Keywords | Aconitum Aconitine Toxicology Drug processing Detoxification |
Issue Date | 2021 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/home |
Citation | Chinese Medicine, 2021, v. 16 n. 1, p. article no. 61 How to Cite? |
Abstract | Aconitum carmichaeli Debx.-derived herbal medicine has been used for anti-inflammation and anti-arrhythmia purpose for more than two thousand years. It is processed into Chuanwu (Radix Aconiti praeparata) and Fuzi (Radix Aconiti lateralis praeparata) in Traditional Chinese Medicine, which are two useful drugs but with toxic properties. There have been patients poisoned by accidental ingestion of Aconitum plants or misuse of the herbal drug, and this is of great concern to study in-depth. In this review, we provided the traditional and contemporary practice of using Aconitum herbs as medicine, from functions, processing methods to toxicity in ethnomedicine aspects to discuss the underlying connections of traditional and modern understanding on the toxicity of Aconitum plants. We summarized the functions and toxicology of the herbal drugs are analyzed from chemical and clinical aspects, with the help of traditional and modern knowledge of medicine. The medicinal doses and lethal doses determined by researches are summarized, and the usage and processing methods are updated and reviewed in the modern view. In addition, clinical management of poisoned cases using western medicine is discussed. This review provides insights and awareness of safety when using Aconitum-derived herbal medicine, and the application of modern scientific knowledge to optimize the detoxification processes. We suggest the possibility to renew the current standard processing method from the official Pharmacopoeia all over the world. |
Persistent Identifier | http://hdl.handle.net/10722/301534 |
ISSN | 2021 Impact Factor: 4.546 2020 SCImago Journal Rankings: 0.972 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | CHAN, YT | - |
dc.contributor.author | Wang, N | - |
dc.contributor.author | Feng, Y | - |
dc.date.accessioned | 2021-08-09T03:40:28Z | - |
dc.date.available | 2021-08-09T03:40:28Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Chinese Medicine, 2021, v. 16 n. 1, p. article no. 61 | - |
dc.identifier.issn | 1749-8546 | - |
dc.identifier.uri | http://hdl.handle.net/10722/301534 | - |
dc.description.abstract | Aconitum carmichaeli Debx.-derived herbal medicine has been used for anti-inflammation and anti-arrhythmia purpose for more than two thousand years. It is processed into Chuanwu (Radix Aconiti praeparata) and Fuzi (Radix Aconiti lateralis praeparata) in Traditional Chinese Medicine, which are two useful drugs but with toxic properties. There have been patients poisoned by accidental ingestion of Aconitum plants or misuse of the herbal drug, and this is of great concern to study in-depth. In this review, we provided the traditional and contemporary practice of using Aconitum herbs as medicine, from functions, processing methods to toxicity in ethnomedicine aspects to discuss the underlying connections of traditional and modern understanding on the toxicity of Aconitum plants. We summarized the functions and toxicology of the herbal drugs are analyzed from chemical and clinical aspects, with the help of traditional and modern knowledge of medicine. The medicinal doses and lethal doses determined by researches are summarized, and the usage and processing methods are updated and reviewed in the modern view. In addition, clinical management of poisoned cases using western medicine is discussed. This review provides insights and awareness of safety when using Aconitum-derived herbal medicine, and the application of modern scientific knowledge to optimize the detoxification processes. We suggest the possibility to renew the current standard processing method from the official Pharmacopoeia all over the world. | - |
dc.language | eng | - |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/home | - |
dc.relation.ispartof | Chinese Medicine | - |
dc.rights | Chinese Medicine. Copyright © BioMed Central Ltd. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Aconitum | - |
dc.subject | Aconitine | - |
dc.subject | Toxicology | - |
dc.subject | Drug processing | - |
dc.subject | Detoxification | - |
dc.title | The toxicology and detoxification of Aconitum: traditional and modern views | - |
dc.type | Article | - |
dc.identifier.email | Wang, N: ckwang@hku.hk | - |
dc.identifier.email | Feng, Y: yfeng@hku.hk | - |
dc.identifier.authority | Wang, N=rp02075 | - |
dc.identifier.authority | Feng, Y=rp00466 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/s13020-021-00472-9 | - |
dc.identifier.pmid | 34315520 | - |
dc.identifier.pmcid | PMC8314510 | - |
dc.identifier.scopus | eid_2-s2.0-85111380192 | - |
dc.identifier.hkuros | 324023 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 61 | - |
dc.identifier.epage | article no. 61 | - |
dc.identifier.isi | WOS:000678612700001 | - |
dc.publisher.place | United Kingdom | - |