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Article: Label-free detection of alanine aminotransferase using a graphene field-effect biosensor

TitleLabel-free detection of alanine aminotransferase using a graphene field-effect biosensor
Authors
Her, Jim LongPan, Tung MingLin, Wan YingWang, Kai ShengLi, Lain Jong
Keywordsl-Alanine
Alanine aminotransferase (ALT)
α-Ketoglutarate
Graphene field-effect transistor (GFET)
Issue Date2013
Citation
Sensors and Actuators, B: Chemical, 2013, v. 182, p. 396-400 How to Cite?
DOI: http://dx.doi.org/10.1016/j.snb.2013.03.026
AbstractIn this paper, we developed a low operation voltage and a single reaction step of a graphene field-effect transistor (GFET) biosensor device to detect alanine aminotransferase (ALT). The device is fabricated using large-area graphene thin films by means of chemical vapor deposition. The GFET device operated at 0.1 V drain voltage and -0.1 to 0.3 V sweep gate voltage exhibited a high pH sensitivity of 23.12 mV/pH, a low hysteresis voltage of 1.2 mV, and a small drift rate of 4.74 mV/h. In this research, the hybrid configuration of l-alanine and α-ketoglutarate immobilized on the graphene membrane was proved to be able to detect ALT with good linearity (R = 0.99) in the ALT concentration range of 10-100 U/L. © 2013 Elsevier B.V. 2
Persistent Identifierhttp://hdl.handle.net/10722/298027
ISSN
0925-4005
2021 Impact Factor: 9.221
2020 SCImago Journal Rankings: 1.601
ISI Accession Number ID
WOS:000319488800054

 

DC FieldValueLanguage
dc.contributor.authorHer, Jim Long-
dc.contributor.authorPan, Tung Ming-
dc.contributor.authorLin, Wan Ying-
dc.contributor.authorWang, Kai Sheng-
dc.contributor.authorLi, Lain Jong-
dc.date.accessioned2021-04-08T03:07:30Z-
dc.date.available2021-04-08T03:07:30Z-
dc.date.issued2013-
dc.identifier.citationSensors and Actuators, B: Chemical, 2013, v. 182, p. 396-400-
dc.identifier.issn0925-4005-
dc.identifier.urihttp://hdl.handle.net/10722/298027-
dc.description.abstractIn this paper, we developed a low operation voltage and a single reaction step of a graphene field-effect transistor (GFET) biosensor device to detect alanine aminotransferase (ALT). The device is fabricated using large-area graphene thin films by means of chemical vapor deposition. The GFET device operated at 0.1 V drain voltage and -0.1 to 0.3 V sweep gate voltage exhibited a high pH sensitivity of 23.12 mV/pH, a low hysteresis voltage of 1.2 mV, and a small drift rate of 4.74 mV/h. In this research, the hybrid configuration of l-alanine and α-ketoglutarate immobilized on the graphene membrane was proved to be able to detect ALT with good linearity (R = 0.99) in the ALT concentration range of 10-100 U/L. © 2013 Elsevier B.V. 2-
dc.languageeng-
dc.relation.ispartofSensors and Actuators, B: Chemical-
dc.subjectl-Alanine-
dc.subjectAlanine aminotransferase (ALT)-
dc.subjectα-Ketoglutarate-
dc.subjectGraphene field-effect transistor (GFET)-
dc.titleLabel-free detection of alanine aminotransferase using a graphene field-effect biosensor-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.snb.2013.03.026-
dc.identifier.scopuseid_2-s2.0-84876146969-
dc.identifier.volume182-
dc.identifier.spage396-
dc.identifier.epage400-
dc.identifier.isiWOS:000319488800054-
dc.identifier.issnl0925-4005-

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