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Article: Antibacterial membrane with a bone-like structure for guided bone regeneration

TitleAntibacterial membrane with a bone-like structure for guided bone regeneration
Authors
Issue Date2015
PublisherHindawi Limited. The Journal's web site is located at https://www.hindawi.com/journals/JNM/index.html
Citation
Journal of Nanomaterials, 2015, v. 2015, article no. 784574 How to Cite?
AbstractAn antibacterial membrane with a bone-like structure was developed for guided bone regeneration (GBR) by mineralising acellular bovine pericardium (ABP) and loading it with the antibiotic minocycline. The bovine pericardium (BP) membrane was processed using physical and chemical methods to remove the cellular components and obtain ABP membranes. Then, the ABP membranes were biomimetically mineralised using a calcium phosphate-loaded agarose hydrogel system aided by electrophoresis. Minocycline was adsorbed to the mineralised ABP membrane, and the release profile in vitro was studied. The membranes were characterised through scanning electron microscopy, diffuse reflectance-Fourier transform infrared spectroscopy, and X-ray diffraction. Results showed that the ABP membrane had an asymmetric structure with a layer of densely arranged and irregularly aligned collagen fibrils. Collagen fibrils were calcified with the formation of intrafibrillar and interfibrillar hydroxyapatites similar to the bone structure. Minocycline was incorporated into the mineralised collagen membrane and could be released in vitro. This process endowed the membrane with an antibacterial property. This novel composite membrane offers promising applications in bioactive GBR.
Persistent Identifierhttp://hdl.handle.net/10722/294585
ISSN
2020 Impact Factor: 2.986
2020 SCImago Journal Rankings: 0.463
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Y-
dc.contributor.authorMao, W-
dc.contributor.authorWang, J-
dc.contributor.authorLi, QL-
dc.contributor.authorMei, ML-
dc.contributor.authorChu, CH-
dc.contributor.authorXia, R-
dc.contributor.authorZhang, ZH-
dc.date.accessioned2020-12-08T07:39:03Z-
dc.date.available2020-12-08T07:39:03Z-
dc.date.issued2015-
dc.identifier.citationJournal of Nanomaterials, 2015, v. 2015, article no. 784574-
dc.identifier.issn1687-4110-
dc.identifier.urihttp://hdl.handle.net/10722/294585-
dc.description.abstractAn antibacterial membrane with a bone-like structure was developed for guided bone regeneration (GBR) by mineralising acellular bovine pericardium (ABP) and loading it with the antibiotic minocycline. The bovine pericardium (BP) membrane was processed using physical and chemical methods to remove the cellular components and obtain ABP membranes. Then, the ABP membranes were biomimetically mineralised using a calcium phosphate-loaded agarose hydrogel system aided by electrophoresis. Minocycline was adsorbed to the mineralised ABP membrane, and the release profile in vitro was studied. The membranes were characterised through scanning electron microscopy, diffuse reflectance-Fourier transform infrared spectroscopy, and X-ray diffraction. Results showed that the ABP membrane had an asymmetric structure with a layer of densely arranged and irregularly aligned collagen fibrils. Collagen fibrils were calcified with the formation of intrafibrillar and interfibrillar hydroxyapatites similar to the bone structure. Minocycline was incorporated into the mineralised collagen membrane and could be released in vitro. This process endowed the membrane with an antibacterial property. This novel composite membrane offers promising applications in bioactive GBR.-
dc.languageeng-
dc.publisherHindawi Limited. The Journal's web site is located at https://www.hindawi.com/journals/JNM/index.html-
dc.relation.ispartofJournal of Nanomaterials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAntibacterial membrane with a bone-like structure for guided bone regeneration-
dc.typeArticle-
dc.identifier.emailMei, ML: mei1123@hku.hk-
dc.identifier.emailChu, CH: chchu@hku.hk-
dc.identifier.authorityMei, ML=rp01840-
dc.identifier.authorityChu, CH=rp00022-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2015/784574-
dc.identifier.scopuseid_2-s2.0-84943329609-
dc.identifier.hkuros320572-
dc.identifier.volume2015-
dc.identifier.spagearticle no. 784574-
dc.identifier.epagearticle no. 784574-
dc.identifier.isiWOS:000362355700001-
dc.publisher.placeUnited Kingdom-

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