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- Publisher Website: 10.1002/admt.202000623
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Article: Engineering Microcapsules for Simultaneous Delivery of Combinational Therapeutics
Title | Engineering Microcapsules for Simultaneous Delivery of Combinational Therapeutics |
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Authors | |
Keywords | biodegradabilities combinational treatments local co‐deliveries microcapsules monodispersities |
Issue Date | 2020 |
Publisher | John Wiley & Sons. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2365-709X |
Citation | Advanced Materials Technologies, 2020, v. 5 n. 11, p. article no. 2000623 How to Cite? |
Abstract | The combination of chemo‐ and photothermal therapy is an effective strategy to improve clinical outcomes and minimize side effects. For simultaneously delivering chemo‐ and photothermal agents to the tumor region to exert their synergistic effect, an efficient and safe drug co‐delivery platform is in great need. Microcapsules (MCs) are promising drug carriers for local treatment of tumors. However, their applications in chemo‐photothermal combinational therapy have not been fully explored. Herein, novel doxorubicin (DOX) and indocyanine green (ICG)‐incorporated microcapsules (DIMCs) are reported for highly efficient delivery of combinational therapeutics. To obtain DIMCs with precise configuration and controlled drug release characteristics, the microfluidic double‐emulsion templating method is adopted and factors dominating the size and morphology of DIMCs are investigated. Under optimized conditions, DIMCs with well‐defined hydrogel cores and polymeric shells can be steadily prepared, which are hydrolytically degradable, allow for pH‐sensitive sustained release of the drug payload, and show excellent photothermal effects. The in vitro experiment shows that DIMCs exhibit significantly enhanced antitumor efficiency owing to the synergistic effects of chemo‐ and photothermal actives, showing great potential as a new therapeutic platform in local treatment of cancers. |
Persistent Identifier | http://hdl.handle.net/10722/294092 |
ISSN | 2021 Impact Factor: 8.856 2020 SCImago Journal Rankings: 2.184 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Huang, L | - |
dc.contributor.author | Zhou, J | - |
dc.contributor.author | Chen, Y | - |
dc.contributor.author | LI, W | - |
dc.contributor.author | HAN, X | - |
dc.contributor.author | Wang, L | - |
dc.date.accessioned | 2020-11-23T08:26:13Z | - |
dc.date.available | 2020-11-23T08:26:13Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Advanced Materials Technologies, 2020, v. 5 n. 11, p. article no. 2000623 | - |
dc.identifier.issn | 2365-709X | - |
dc.identifier.uri | http://hdl.handle.net/10722/294092 | - |
dc.description.abstract | The combination of chemo‐ and photothermal therapy is an effective strategy to improve clinical outcomes and minimize side effects. For simultaneously delivering chemo‐ and photothermal agents to the tumor region to exert their synergistic effect, an efficient and safe drug co‐delivery platform is in great need. Microcapsules (MCs) are promising drug carriers for local treatment of tumors. However, their applications in chemo‐photothermal combinational therapy have not been fully explored. Herein, novel doxorubicin (DOX) and indocyanine green (ICG)‐incorporated microcapsules (DIMCs) are reported for highly efficient delivery of combinational therapeutics. To obtain DIMCs with precise configuration and controlled drug release characteristics, the microfluidic double‐emulsion templating method is adopted and factors dominating the size and morphology of DIMCs are investigated. Under optimized conditions, DIMCs with well‐defined hydrogel cores and polymeric shells can be steadily prepared, which are hydrolytically degradable, allow for pH‐sensitive sustained release of the drug payload, and show excellent photothermal effects. The in vitro experiment shows that DIMCs exhibit significantly enhanced antitumor efficiency owing to the synergistic effects of chemo‐ and photothermal actives, showing great potential as a new therapeutic platform in local treatment of cancers. | - |
dc.language | eng | - |
dc.publisher | John Wiley & Sons. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2365-709X | - |
dc.relation.ispartof | Advanced Materials Technologies | - |
dc.rights | Preprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | biodegradabilities | - |
dc.subject | combinational treatments | - |
dc.subject | local co‐deliveries | - |
dc.subject | microcapsules | - |
dc.subject | monodispersities | - |
dc.title | Engineering Microcapsules for Simultaneous Delivery of Combinational Therapeutics | - |
dc.type | Article | - |
dc.identifier.email | Wang, L: lqwang@hku.hk | - |
dc.identifier.authority | Wang, L=rp00184 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/admt.202000623 | - |
dc.identifier.scopus | eid_2-s2.0-85090089041 | - |
dc.identifier.hkuros | 319568 | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | article no. 2000623 | - |
dc.identifier.epage | article no. 2000623 | - |
dc.identifier.isi | WOS:000564973400001 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 2365-709X | - |