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Article: A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections

TitleA tailored positively-charged hydrophobic surface reduces the risk of implant associated infections
Authors
KeywordsOrthopedic implant
Titanium alloy
Surface modification
Antimicrobial property
Biocompatibility
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
Citation
Acta Biomaterialia, 2020, v. 114, p. 421-430 How to Cite?
AbstractImplant-associated infections is one of the most challenging post-operative complications in bone-related implantations. To tackle this clinical issue, we developed a low-cost and durable surface coating for medical grade titanium implants that uses positively charged silane molecules. The in vitro antimicrobial tests revealed that the titanium surface coated with (3-aminopropyl) triethoxysilane, which has the appropriate length of hydrophobic alkyl chain and positive charged amino group, suppressed more than 90% of the initial bacterial adhesion of S. aureus, P. aeruginosa, and E. coli after 30 min of incubation. In terms of growth inhibitory rate, the treated surface was able to reduce 75.7% ± 11.9% of bacterial growth after a 24-hour culturing, thereby exhibiting superior anti-biofilm formation in the late stage. When implanted into the rat model infected by S. aureus, the treated surface eliminated the implant-associated infection through the mechanism of inhibition of bacterial adhesion on the implant surface. Additionally, the treated surface was highly compatible with mammalian cells. In general, our design demonstrated its potential for human clinical trials as a low-cost and effective antibacterial strategy to minimize post-operative implant-related bacterial infection.
Persistent Identifierhttp://hdl.handle.net/10722/289785
ISSN
2019 Impact Factor: 7.242
2015 SCImago Journal Rankings: 2.020

 

DC FieldValueLanguage
dc.contributor.authorShen, J-
dc.contributor.authorGao, P-
dc.contributor.authorHAN, S-
dc.contributor.authorKao, RYT-
dc.contributor.authorWU, S-
dc.contributor.authorLIU, X-
dc.contributor.authorQIAN, S-
dc.contributor.authorCHU, PK-
dc.contributor.authorCheung, KMC-
dc.contributor.authorYeung, KWK-
dc.date.accessioned2020-10-22T08:17:26Z-
dc.date.available2020-10-22T08:17:26Z-
dc.date.issued2020-
dc.identifier.citationActa Biomaterialia, 2020, v. 114, p. 421-430-
dc.identifier.issn1742-7061-
dc.identifier.urihttp://hdl.handle.net/10722/289785-
dc.description.abstractImplant-associated infections is one of the most challenging post-operative complications in bone-related implantations. To tackle this clinical issue, we developed a low-cost and durable surface coating for medical grade titanium implants that uses positively charged silane molecules. The in vitro antimicrobial tests revealed that the titanium surface coated with (3-aminopropyl) triethoxysilane, which has the appropriate length of hydrophobic alkyl chain and positive charged amino group, suppressed more than 90% of the initial bacterial adhesion of S. aureus, P. aeruginosa, and E. coli after 30 min of incubation. In terms of growth inhibitory rate, the treated surface was able to reduce 75.7% ± 11.9% of bacterial growth after a 24-hour culturing, thereby exhibiting superior anti-biofilm formation in the late stage. When implanted into the rat model infected by S. aureus, the treated surface eliminated the implant-associated infection through the mechanism of inhibition of bacterial adhesion on the implant surface. Additionally, the treated surface was highly compatible with mammalian cells. In general, our design demonstrated its potential for human clinical trials as a low-cost and effective antibacterial strategy to minimize post-operative implant-related bacterial infection.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat-
dc.relation.ispartofActa Biomaterialia-
dc.subjectOrthopedic implant-
dc.subjectTitanium alloy-
dc.subjectSurface modification-
dc.subjectAntimicrobial property-
dc.subjectBiocompatibility-
dc.titleA tailored positively-charged hydrophobic surface reduces the risk of implant associated infections-
dc.typeArticle-
dc.identifier.emailShen, J: jieshen@hku.hk-
dc.identifier.emailGao, P: gaopeng@hku.hk-
dc.identifier.emailKao, RYT: rytkao@hkucc.hku.hk-
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityKao, RYT=rp00481-
dc.identifier.authorityCheung, KMC=rp00387-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.actbio.2020.07.040-
dc.identifier.pmid32711080-
dc.identifier.scopuseid_2-s2.0-85088780988-
dc.identifier.hkuros316853-
dc.identifier.volume114-
dc.identifier.spage421-
dc.identifier.epage430-
dc.publisher.placeNetherlands-

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