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Article: The dorsal and the ventral side of hypoglossal motor nucleus showed different response to chronic intermittent hypoxia in rats

TitleThe dorsal and the ventral side of hypoglossal motor nucleus showed different response to chronic intermittent hypoxia in rats
Authors
KeywordsSleep apnea
Chronic intermittent hypoxia
5-HT
5-HT 2A
Issue Date2020
PublisherSpringer Verlag. The Journal's web site is located at http://www.springer.com/medicine/internal/journal/11325
Citation
Sleep and Breathing, 2020, Epub 2020-06-19 How to Cite?
AbstractPurpose: To study neurochemical reactions to chronic intermittent hypoxia (CIH) in the hypoglossal nucleus (HN) of rats. Methods: Adult male Sprague-Dawley rats (n = 12) were randomly divided into two groups (the CIH and the control group). The CIH rats were housed in a hypoxic chamber with the fraction of oxygen volume alternating between 21% and 5% by providing air for 60 s and then providing nitrogen for 60 s from 8:30 am to 16:30 pm each day for 35 days. The control group was housed in a cabin with normal oxygen levels. We studied the expression of c-fos protein, 5-hydroxytryptamine (5-HT) positive terminals, and its 2A receptors in hypoglossal nuclei by immunohistochemistry. Results: The expression of c-fos, 5-HT positive terminals, and accordingly 5-HT 2A receptors in the CIH group were significantly higher than that in the controls (p < 0.05). The ventral side of the HN showed a clearly higher expression of 5-HT and its 2A receptors than the dorsal side (p < 0.05). Conclusion: There were 2 responses of the HN to CIH. First, CIH induced a higher expression of 5-HT positive terminals and its 2A receptors, and second, this reaction was much more evident in ventral side than in the dorsal side. We postulate that these responses may serve to be a protective and compensatory mechanism for CIH.
Persistent Identifierhttp://hdl.handle.net/10722/287310
ISSN
2019 Impact Factor: 2.162
2015 SCImago Journal Rankings: 0.832

 

DC FieldValueLanguage
dc.contributor.authorCao, R-
dc.contributor.authorZhang, MJ-
dc.contributor.authorZhou, YT-
dc.contributor.authorLiu, YJ-
dc.contributor.authorWang, HH-
dc.contributor.authorZhang, QX-
dc.contributor.authorShi, YW-
dc.contributor.authorLi, JC-
dc.contributor.authorWong, TS-
dc.contributor.authorYin, M-
dc.date.accessioned2020-09-22T02:59:03Z-
dc.date.available2020-09-22T02:59:03Z-
dc.date.issued2020-
dc.identifier.citationSleep and Breathing, 2020, Epub 2020-06-19-
dc.identifier.issn1520-9512-
dc.identifier.urihttp://hdl.handle.net/10722/287310-
dc.description.abstractPurpose: To study neurochemical reactions to chronic intermittent hypoxia (CIH) in the hypoglossal nucleus (HN) of rats. Methods: Adult male Sprague-Dawley rats (n = 12) were randomly divided into two groups (the CIH and the control group). The CIH rats were housed in a hypoxic chamber with the fraction of oxygen volume alternating between 21% and 5% by providing air for 60 s and then providing nitrogen for 60 s from 8:30 am to 16:30 pm each day for 35 days. The control group was housed in a cabin with normal oxygen levels. We studied the expression of c-fos protein, 5-hydroxytryptamine (5-HT) positive terminals, and its 2A receptors in hypoglossal nuclei by immunohistochemistry. Results: The expression of c-fos, 5-HT positive terminals, and accordingly 5-HT 2A receptors in the CIH group were significantly higher than that in the controls (p < 0.05). The ventral side of the HN showed a clearly higher expression of 5-HT and its 2A receptors than the dorsal side (p < 0.05). Conclusion: There were 2 responses of the HN to CIH. First, CIH induced a higher expression of 5-HT positive terminals and its 2A receptors, and second, this reaction was much more evident in ventral side than in the dorsal side. We postulate that these responses may serve to be a protective and compensatory mechanism for CIH.-
dc.languageeng-
dc.publisherSpringer Verlag. The Journal's web site is located at http://www.springer.com/medicine/internal/journal/11325-
dc.relation.ispartofSleep and Breathing-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectSleep apnea-
dc.subjectChronic intermittent hypoxia-
dc.subject5-HT-
dc.subject5-HT 2A-
dc.titleThe dorsal and the ventral side of hypoglossal motor nucleus showed different response to chronic intermittent hypoxia in rats-
dc.typeArticle-
dc.identifier.emailWong, TS: wongtsa@hkucc.hku.hk-
dc.identifier.authorityWong, TS=rp00478-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11325-020-02125-x-
dc.identifier.scopuseid_2-s2.0-85086652406-
dc.identifier.hkuros314387-
dc.identifier.volumeEpub 2020-06-19-
dc.publisher.placeGermany-

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