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Article: Collagen Induces a More Proliferative, Migratory and Chemoresistant Phenotype in Head and Neck Cancer via DDR1

TitleCollagen Induces a More Proliferative, Migratory and Chemoresistant Phenotype in Head and Neck Cancer via DDR1
Authors
KeywordsHead and neck cancer
Collagen
DDR1
Issue Date2019
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cancers/
Citation
Cancers, 2019, v. 11 n. 11, article no. 1766 How to Cite?
AbstractHead and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and includes squamous cell carcinomas of the oropharynx and oral cavity. Patient prognosis has remained poor for decades and molecular targeted therapies are not in routine use. Here we showed that the overall expression of collagen subunit genes was higher in cancer-associated fibroblasts (CAFs) than normal fibroblasts. Focusing on collagen8A1 and collagen11A1, we showed that collagen is produced by both CAFs and tumour cells, indicating that HNSCCs are collagen-rich environments. We then focused on discoidin domain receptor 1 (DDR1), a collagen-activated receptor tyrosine kinase, and showed that it is over-expressed in HNSCC tissues. Further, we demonstrated that collagen promoted the proliferation and migration of HNSCC cells and attenuated the apoptotic response to cisplatin. Knockdown of DDR1 in HNSCC cells demonstrated that these tumour-promoting effects of collagen are mediated by DDR1. Our data suggest that specific inhibitors of DDR1 might provide novel therapeutic opportunities to treat HNSCC.
Persistent Identifierhttp://hdl.handle.net/10722/286506
ISSN
2018 Impact Factor: 6.162
2015 SCImago Journal Rankings: 1.630
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, SL-
dc.contributor.authorTan, ML-
dc.contributor.authorHollows, RJ-
dc.contributor.authorRobinson, M-
dc.contributor.authorIbrahim, M-
dc.contributor.authorMargielewska, S-
dc.contributor.authorParkinson, EK-
dc.contributor.authorRamanathan, A-
dc.contributor.authorZain, RB-
dc.contributor.authorMehanna, H-
dc.contributor.authorSpruce, RJ-
dc.contributor.authorWei, W-
dc.contributor.authorChung, I-
dc.contributor.authorMurray, PG-
dc.contributor.authorYap, LF-
dc.contributor.authorPaterson, IC-
dc.date.accessioned2020-08-31T07:04:49Z-
dc.date.available2020-08-31T07:04:49Z-
dc.date.issued2019-
dc.identifier.citationCancers, 2019, v. 11 n. 11, article no. 1766-
dc.identifier.issn2072-6694-
dc.identifier.urihttp://hdl.handle.net/10722/286506-
dc.description.abstractHead and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and includes squamous cell carcinomas of the oropharynx and oral cavity. Patient prognosis has remained poor for decades and molecular targeted therapies are not in routine use. Here we showed that the overall expression of collagen subunit genes was higher in cancer-associated fibroblasts (CAFs) than normal fibroblasts. Focusing on collagen8A1 and collagen11A1, we showed that collagen is produced by both CAFs and tumour cells, indicating that HNSCCs are collagen-rich environments. We then focused on discoidin domain receptor 1 (DDR1), a collagen-activated receptor tyrosine kinase, and showed that it is over-expressed in HNSCC tissues. Further, we demonstrated that collagen promoted the proliferation and migration of HNSCC cells and attenuated the apoptotic response to cisplatin. Knockdown of DDR1 in HNSCC cells demonstrated that these tumour-promoting effects of collagen are mediated by DDR1. Our data suggest that specific inhibitors of DDR1 might provide novel therapeutic opportunities to treat HNSCC.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cancers/-
dc.relation.ispartofCancers-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHead and neck cancer-
dc.subjectCollagen-
dc.subjectDDR1-
dc.titleCollagen Induces a More Proliferative, Migratory and Chemoresistant Phenotype in Head and Neck Cancer via DDR1-
dc.typeArticle-
dc.identifier.emailLai, SL: sookling@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/cancers11111766-
dc.identifier.pmid31717573-
dc.identifier.pmcidPMC6896141-
dc.identifier.scopuseid_2-s2.0-85074719419-
dc.identifier.hkuros313725-
dc.identifier.volume11-
dc.identifier.issue11-
dc.identifier.spagearticle no. 1766-
dc.identifier.epagearticle no. 1766-
dc.identifier.isiWOS:000502290100148-
dc.publisher.placeSwitzerland-

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