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Article: Wolfberry‐Derived Zeaxanthin Dipalmitate Attenuates Ethanol‐Induced Hepatic Damage

TitleWolfberry‐Derived Zeaxanthin Dipalmitate Attenuates Ethanol‐Induced Hepatic Damage
Authors
Keywordsalcoholic fatty liver disease
immediate receptor
inflammasome
mitophagy
zeaxanthin dipalmitate
Issue Date2019
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-4133
Citation
Molecular Nutrition & Food Research, 2019, v. 63 n. 11, p. article no. 1801339 How to Cite?
AbstractScope: Besides abstinence and nutritional support, there is no proven clinical treatment for patients with alcoholic fatty liver disease (AFLD). Here, the therapeutic effects and mechanisms of action of wolfberry‐derived zeaxanthin dipalmitate (ZD) on AFLD models are demonstrated. Methods and results: The hepatoprotective effects of ZD are evaluated in vitro and in vivo. Direct interacting receptors of ZD on cell membranes are identified by liver‐specific knockdown and biophysical measurements. Downstream signaling pathways are delineated using molecular and cellular biological methods. It is demonstrated that ZD attenuates hepatocyte and whole‐liver injury in ethanol‐treated cells (dose: 1 µm) and a chronic binge AFLD rat model (dose: 10 mg kg–1), respectively. The direct targets of ZD on the cell membrane include receptor P2X7 and adiponectin receptor 1 (adipoR1). Signals from P2X7 and adipoR1 modulate the phosphatidylinositide 3‐kinase‐Akt and/or AMP‐activated protein kinase‐FoxO3a pathways, to restore mitochondrial autophagy (mitophagy) functions suppressed by ethanol intoxication. In addition, ZD alleviates hepatic inflammation partially via the inhibition of Nod‐like receptor 3 inflammasome, whose activation is a direct consequence of suppressed mitophagy. Liver‐specific inhibition of receptors or mitophagy significantly impairs the beneficial effects of ZD. Conclusions: ZD is an effective and promising agent for the potential treatment of AFLD.
Persistent Identifierhttp://hdl.handle.net/10722/285430
ISSN
2019 Impact Factor: 5.309
2015 SCImago Journal Rankings: 1.679

 

DC FieldValueLanguage
dc.contributor.authorGao, H-
dc.contributor.authorLv, Y-
dc.contributor.authorLiu, Y-
dc.contributor.authorLi, J-
dc.contributor.authorWang, X-
dc.contributor.authorZhou, Z-
dc.contributor.authorTipoe, GL-
dc.contributor.authorQuyang, S-
dc.contributor.authorGuo, Y-
dc.contributor.authorZhang, J-
dc.contributor.authorHao, X-
dc.contributor.authorLi, W-
dc.contributor.authorKoike, K-
dc.contributor.authorSo, KF-
dc.contributor.authorXiao, J-
dc.date.accessioned2020-08-18T03:53:20Z-
dc.date.available2020-08-18T03:53:20Z-
dc.date.issued2019-
dc.identifier.citationMolecular Nutrition & Food Research, 2019, v. 63 n. 11, p. article no. 1801339-
dc.identifier.issn1613-4125-
dc.identifier.urihttp://hdl.handle.net/10722/285430-
dc.description.abstractScope: Besides abstinence and nutritional support, there is no proven clinical treatment for patients with alcoholic fatty liver disease (AFLD). Here, the therapeutic effects and mechanisms of action of wolfberry‐derived zeaxanthin dipalmitate (ZD) on AFLD models are demonstrated. Methods and results: The hepatoprotective effects of ZD are evaluated in vitro and in vivo. Direct interacting receptors of ZD on cell membranes are identified by liver‐specific knockdown and biophysical measurements. Downstream signaling pathways are delineated using molecular and cellular biological methods. It is demonstrated that ZD attenuates hepatocyte and whole‐liver injury in ethanol‐treated cells (dose: 1 µm) and a chronic binge AFLD rat model (dose: 10 mg kg–1), respectively. The direct targets of ZD on the cell membrane include receptor P2X7 and adiponectin receptor 1 (adipoR1). Signals from P2X7 and adipoR1 modulate the phosphatidylinositide 3‐kinase‐Akt and/or AMP‐activated protein kinase‐FoxO3a pathways, to restore mitochondrial autophagy (mitophagy) functions suppressed by ethanol intoxication. In addition, ZD alleviates hepatic inflammation partially via the inhibition of Nod‐like receptor 3 inflammasome, whose activation is a direct consequence of suppressed mitophagy. Liver‐specific inhibition of receptors or mitophagy significantly impairs the beneficial effects of ZD. Conclusions: ZD is an effective and promising agent for the potential treatment of AFLD.-
dc.languageeng-
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-4133-
dc.relation.ispartofMolecular Nutrition & Food Research-
dc.rightsThis is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectalcoholic fatty liver disease-
dc.subjectimmediate receptor-
dc.subjectinflammasome-
dc.subjectmitophagy-
dc.subjectzeaxanthin dipalmitate-
dc.titleWolfberry‐Derived Zeaxanthin Dipalmitate Attenuates Ethanol‐Induced Hepatic Damage-
dc.typeArticle-
dc.identifier.emailTipoe, GL: tgeorge@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.authorityTipoe, GL=rp00371-
dc.identifier.authoritySo, KF=rp00329-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/mnfr.201801339-
dc.identifier.pmid30938072-
dc.identifier.scopuseid_2-s2.0-85064148667-
dc.identifier.hkuros312695-
dc.identifier.volume63-
dc.identifier.issue11-
dc.identifier.spagearticle no. 1801339-
dc.identifier.epagearticle no. 1801339-
dc.publisher.placeGermany-

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