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Article: Anatomical versus nonanatomical resection for colorectal liver metastasis

TitleAnatomical versus nonanatomical resection for colorectal liver metastasis
Authors
Issue Date2020
PublisherSpringer for International Society of Surgery. The Journal's web site is located at http://www.springer.com/medicine/surgery/journal/268
Citation
World Journal of Surgery, 2020, v. 44 n. 8, p. 2743-2751 How to Cite?
AbstractBackground: Anatomical resection (AR) for colorectal liver metastasis (CLM) is disputable. We investigated the impact of AR on short-term outcomes and survival in CLM patients. Methods: Patients having hepatectomy with AR or nonanatomical resection (NAR) for CLM were reviewed. Comparison was made between AR and NAR groups. Group comparison was performed again after propensity score matching with ratio 1:1. Results: AR group (n = 234 vs n = 89 in NAR group) had higher carcinoembryonic antigen level (20 vs 7.8 ng/mL, p ≤ 0.001), more blood loss (0.65 vs 0.2 L, p < 0.001), more transfusions (19.2% vs 3.4%, p = 0.001), longer operation (339.5 vs 180 min, p < 0.001), longer hospital stay (9 vs 6 days, p < 0.001), more tumors (p < 0.001), larger tumors (4 vs 2 cm, p < 0.001), more bilobar involvement (20.9% vs 7.9%, p = 0.006), and comparable survival (overall, p = 0.721; disease-free, p = 0.695). After propensity score matching, each group had 70 patients, with matched tumor number, tumor size, liver function, and tumor marker. AR group had more open resections (85.7% vs 68.6%, p = 0.016), more blood loss (0.556 vs 0.3 L, p = 0.001), more transfusions (17.1% vs 4.3%, p = 0.015), longer operation (310 vs 180 min, p < 0.001), longer hospital stay (8.5 vs 6 days, p = 0.002), comparable overall survival (p = 0.819), and comparable disease-free survival (p = 0.855). Conclusion: Similar disease-free survival and overall survival of CLM patients were seen with the use of AR and NAR. However, AR may entail a more eventful postoperative course. NAR with margin should be considered whenever feasible.
Persistent Identifierhttp://hdl.handle.net/10722/285317
ISSN
2019 Impact Factor: 2.234
2015 SCImago Journal Rankings: 1.375
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShe, WH-
dc.contributor.authorCheung, TT-
dc.contributor.authorMa, KW-
dc.contributor.authorTsang, SHY-
dc.contributor.authorDai, WC-
dc.contributor.authorChan, ACY-
dc.contributor.authorLo, CM-
dc.date.accessioned2020-08-18T03:52:21Z-
dc.date.available2020-08-18T03:52:21Z-
dc.date.issued2020-
dc.identifier.citationWorld Journal of Surgery, 2020, v. 44 n. 8, p. 2743-2751-
dc.identifier.issn0364-2313-
dc.identifier.urihttp://hdl.handle.net/10722/285317-
dc.description.abstractBackground: Anatomical resection (AR) for colorectal liver metastasis (CLM) is disputable. We investigated the impact of AR on short-term outcomes and survival in CLM patients. Methods: Patients having hepatectomy with AR or nonanatomical resection (NAR) for CLM were reviewed. Comparison was made between AR and NAR groups. Group comparison was performed again after propensity score matching with ratio 1:1. Results: AR group (n = 234 vs n = 89 in NAR group) had higher carcinoembryonic antigen level (20 vs 7.8 ng/mL, p ≤ 0.001), more blood loss (0.65 vs 0.2 L, p < 0.001), more transfusions (19.2% vs 3.4%, p = 0.001), longer operation (339.5 vs 180 min, p < 0.001), longer hospital stay (9 vs 6 days, p < 0.001), more tumors (p < 0.001), larger tumors (4 vs 2 cm, p < 0.001), more bilobar involvement (20.9% vs 7.9%, p = 0.006), and comparable survival (overall, p = 0.721; disease-free, p = 0.695). After propensity score matching, each group had 70 patients, with matched tumor number, tumor size, liver function, and tumor marker. AR group had more open resections (85.7% vs 68.6%, p = 0.016), more blood loss (0.556 vs 0.3 L, p = 0.001), more transfusions (17.1% vs 4.3%, p = 0.015), longer operation (310 vs 180 min, p < 0.001), longer hospital stay (8.5 vs 6 days, p = 0.002), comparable overall survival (p = 0.819), and comparable disease-free survival (p = 0.855). Conclusion: Similar disease-free survival and overall survival of CLM patients were seen with the use of AR and NAR. However, AR may entail a more eventful postoperative course. NAR with margin should be considered whenever feasible.-
dc.languageeng-
dc.publisherSpringer for International Society of Surgery. The Journal's web site is located at http://www.springer.com/medicine/surgery/journal/268-
dc.relation.ispartofWorld Journal of Surgery-
dc.titleAnatomical versus nonanatomical resection for colorectal liver metastasis-
dc.typeArticle-
dc.identifier.emailShe, WH: brianshe@hku.hk-
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.emailDai, WC: daiwc@hku.hk-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityCheung, TT=rp02129-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authorityLo, CM=rp00412-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00268-020-05506-1-
dc.identifier.pmid32535643-
dc.identifier.scopuseid_2-s2.0-85086345670-
dc.identifier.hkuros312943-
dc.identifier.volume44-
dc.identifier.issue8-
dc.identifier.spage2743-
dc.identifier.epage2751-
dc.identifier.isiWOS:000539968500004-
dc.publisher.placeUnited States-

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