File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis

TitleAssociation of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis
Authors
KeywordsPhysical activity
Cardiovascular diseases
Mendelian randomization
Causality
Issue Date2020
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.lipidworld.com
Citation
Lipids in Health and Disease, 2020, v. 19, p. article no. 86 How to Cite?
AbstractBackground: Observational studies have shown that moderate-to-vigorous physical activity (MVPA), vigorous physical activity (VPA), sedentary behaviours, and sleep duration were associated with cardiovascular diseases (CVDs) and lipid levels. However, whether such observations reflect causality remain largely unknown. We aimed to investigate the causal associations of physical activity, sedentary behaviours, and sleep duration with coronary artery disease (CAD), myocardial infarction (MI), stroke and lipid levels. Methods: We conducted a Mendelian randomization (MR) study using genetic variants as instruments which are associated with physical activity, sedentary behaviours, and sleep duration to examine the causal effects on CVDs and lipid levels. This study included analyses of 4 potentially modifiable factors and 7 outcomes. Thus, the threshold of statistical significance is P = 1.8 × 10− 3 (0.05/4 × 7) after Bonferroni correction. Results: In the present study, there was suggestive evidence for associations of genetically predicted VPA with CAD (odds ratio, 0.65; 95% confidence intervals, 0.47–0.90; P = 0.009) and MI (0.74; 0.59–0.93; P = 0.010). However, genetically predicted VPA, MVPA, sleep duration and sedentary behaviours did not show significant associations with stroke and any lipid levels. Conclusions: Our findings from the MR approach provided suggestive evidence that vigorous exercise decreased risk of CAD and MI, but not stroke. However, there was no evidence to support causal associations of MVPA,sleep duration or sedentary behaviours with cardiovascular risk and lipid levels. Translational perspective: The findings of this study did not point out specific recommendations on increasing physical activity required to deliver significant health benefits. Nevertheless, the findings allowed clinicians and public health practitioners to provide advice about increasing the total amount of excising time by demonstrating that such advice can be effective. Reliable assessment of the association of physical activity levels with different subtypes of CVDs is needed to provide the basis for a comprehensive clinical approach on CVDs prevention, which can be achieved through lifestyle interventions in addition to drug therapy.
Persistent Identifierhttp://hdl.handle.net/10722/284855
ISSN
2018 Impact Factor: 2.651
2015 SCImago Journal Rankings: 0.976
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorZhuang, Z-
dc.contributor.authorGao, M-
dc.contributor.authorYang, R-
dc.contributor.authorLi, N-
dc.contributor.authorLiu, Z-
dc.contributor.authorCao, W-
dc.contributor.authorHuang, T-
dc.date.accessioned2020-08-07T09:03:31Z-
dc.date.available2020-08-07T09:03:31Z-
dc.date.issued2020-
dc.identifier.citationLipids in Health and Disease, 2020, v. 19, p. article no. 86-
dc.identifier.issn1476-511X-
dc.identifier.urihttp://hdl.handle.net/10722/284855-
dc.description.abstractBackground: Observational studies have shown that moderate-to-vigorous physical activity (MVPA), vigorous physical activity (VPA), sedentary behaviours, and sleep duration were associated with cardiovascular diseases (CVDs) and lipid levels. However, whether such observations reflect causality remain largely unknown. We aimed to investigate the causal associations of physical activity, sedentary behaviours, and sleep duration with coronary artery disease (CAD), myocardial infarction (MI), stroke and lipid levels. Methods: We conducted a Mendelian randomization (MR) study using genetic variants as instruments which are associated with physical activity, sedentary behaviours, and sleep duration to examine the causal effects on CVDs and lipid levels. This study included analyses of 4 potentially modifiable factors and 7 outcomes. Thus, the threshold of statistical significance is P = 1.8 × 10− 3 (0.05/4 × 7) after Bonferroni correction. Results: In the present study, there was suggestive evidence for associations of genetically predicted VPA with CAD (odds ratio, 0.65; 95% confidence intervals, 0.47–0.90; P = 0.009) and MI (0.74; 0.59–0.93; P = 0.010). However, genetically predicted VPA, MVPA, sleep duration and sedentary behaviours did not show significant associations with stroke and any lipid levels. Conclusions: Our findings from the MR approach provided suggestive evidence that vigorous exercise decreased risk of CAD and MI, but not stroke. However, there was no evidence to support causal associations of MVPA,sleep duration or sedentary behaviours with cardiovascular risk and lipid levels. Translational perspective: The findings of this study did not point out specific recommendations on increasing physical activity required to deliver significant health benefits. Nevertheless, the findings allowed clinicians and public health practitioners to provide advice about increasing the total amount of excising time by demonstrating that such advice can be effective. Reliable assessment of the association of physical activity levels with different subtypes of CVDs is needed to provide the basis for a comprehensive clinical approach on CVDs prevention, which can be achieved through lifestyle interventions in addition to drug therapy.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.lipidworld.com-
dc.relation.ispartofLipids in Health and Disease-
dc.rightsLipids in Health and Disease. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectPhysical activity-
dc.subjectCardiovascular diseases-
dc.subjectMendelian randomization-
dc.subjectCausality-
dc.titleAssociation of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis-
dc.typeArticle-
dc.identifier.emailLiu, Z: zhhliu@hku.hk-
dc.identifier.authorityLiu, Z=rp02429-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12944-020-01257-z-
dc.identifier.pmid32384904-
dc.identifier.pmcidPMC7206776-
dc.identifier.scopuseid_2-s2.0-85084720607-
dc.identifier.hkuros312167-
dc.identifier.volume19-
dc.identifier.spagearticle no. 86-
dc.identifier.epagearticle no. 86-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats