File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Association of hepatitis B surface antigen seropositivity and hepatitis B surface antibody seropositivity with diabetes: a cross-sectional study based on two Chinese populations in Guangdong, China

TitleAssociation of hepatitis B surface antigen seropositivity and hepatitis B surface antibody seropositivity with diabetes: a cross-sectional study based on two Chinese populations in Guangdong, China
Authors
Keywordsdiabetes
hepatitis B surface antigen
hepatitis B surface body
Issue Date2020
PublisherBMJ Publishing Group: BMJ Open. The Journal's web site is located at http://bmjopen.bmj.com
Citation
BMJ Open, 2020, v. 10 n. 7, p. article no. e028968 How to Cite?
AbstractObjectives: To examine whether hepatitis B surface antigen (HBsAg) seropositivity and hepatitis B surface antibody (HBsAb) seropositivity were associated with the presence of diabetes in two population-based studies in southern China, the Guangzhou Biobank Cohort Study (GBCS) and the Major Infectious Disease Prevention and Control (MIDPC) study. Design: A cross-sectional study. Setting: The GBCS was conducted among a community social and welfare organisation with branches in all 10 districts of Guangzhou. The MIDPC was conducted among the community residents in two districts of Guangzhou and three districts of Zhongshan. Participants: 4947 participants from the GBCS and 4357 participants from the MIDPC were included in this study. Primary and secondary outcome measures: Type 2 diabetes was the main study outcome, which was diagnosed by fasting blood glucose ≥7.0 mmol/L, and/or self-reported history of diabetes. Results: After adjusting for age, sex, education, occupation, smoking status, alcohol use, physical activity and body mass index, we found no association of HBsAg seropositivity in GBCS or MIDPC (OR=1.12, 95% CI 0.74 to 1.69, and OR=0.83, 95% CI 0.59 to 1.17, respectively), and HBsAb seropositivity (OR=0.85, 95% CI 0.65 to 1.12, OR=1.00, 95% CI 0.86 to 1.16, respectively) with the presence of diabetes. Null associations were found for analysis pooling GBCS and MIDPC data after similar adjustment. The adjusted OR for the associations of HBsAg seropositivity and HBsAb seropositivity with the presence of diabetes in the pooled sample was 0.91 (95% CI 0.70 to 1.19) and 0.98 (95% CI 0.86 to 1.12), respectively. Conclusions: Taking advantage of data from two large cross-sectional studies, we found no association of serological status of HBsAg and HBsAb with the presence of diabetes or glucose measures.
Persistent Identifierhttp://hdl.handle.net/10722/284747
ISSN
2019 Impact Factor: 2.496
2015 SCImago Journal Rankings: 1.448
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Y-
dc.contributor.authorJiang, C-
dc.contributor.authorHao, Y-
dc.contributor.authorXu, L-
dc.contributor.authorZhang, W-
dc.contributor.authorJin, YL-
dc.contributor.authorZhu, T-
dc.contributor.authorLam, TH-
dc.date.accessioned2020-08-07T09:02:05Z-
dc.date.available2020-08-07T09:02:05Z-
dc.date.issued2020-
dc.identifier.citationBMJ Open, 2020, v. 10 n. 7, p. article no. e028968-
dc.identifier.issn2044-6055-
dc.identifier.urihttp://hdl.handle.net/10722/284747-
dc.description.abstractObjectives: To examine whether hepatitis B surface antigen (HBsAg) seropositivity and hepatitis B surface antibody (HBsAb) seropositivity were associated with the presence of diabetes in two population-based studies in southern China, the Guangzhou Biobank Cohort Study (GBCS) and the Major Infectious Disease Prevention and Control (MIDPC) study. Design: A cross-sectional study. Setting: The GBCS was conducted among a community social and welfare organisation with branches in all 10 districts of Guangzhou. The MIDPC was conducted among the community residents in two districts of Guangzhou and three districts of Zhongshan. Participants: 4947 participants from the GBCS and 4357 participants from the MIDPC were included in this study. Primary and secondary outcome measures: Type 2 diabetes was the main study outcome, which was diagnosed by fasting blood glucose ≥7.0 mmol/L, and/or self-reported history of diabetes. Results: After adjusting for age, sex, education, occupation, smoking status, alcohol use, physical activity and body mass index, we found no association of HBsAg seropositivity in GBCS or MIDPC (OR=1.12, 95% CI 0.74 to 1.69, and OR=0.83, 95% CI 0.59 to 1.17, respectively), and HBsAb seropositivity (OR=0.85, 95% CI 0.65 to 1.12, OR=1.00, 95% CI 0.86 to 1.16, respectively) with the presence of diabetes. Null associations were found for analysis pooling GBCS and MIDPC data after similar adjustment. The adjusted OR for the associations of HBsAg seropositivity and HBsAb seropositivity with the presence of diabetes in the pooled sample was 0.91 (95% CI 0.70 to 1.19) and 0.98 (95% CI 0.86 to 1.12), respectively. Conclusions: Taking advantage of data from two large cross-sectional studies, we found no association of serological status of HBsAg and HBsAb with the presence of diabetes or glucose measures.-
dc.languageeng-
dc.publisherBMJ Publishing Group: BMJ Open. The Journal's web site is located at http://bmjopen.bmj.com-
dc.relation.ispartofBMJ Open-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectdiabetes-
dc.subjecthepatitis B surface antigen-
dc.subjecthepatitis B surface body-
dc.titleAssociation of hepatitis B surface antigen seropositivity and hepatitis B surface antibody seropositivity with diabetes: a cross-sectional study based on two Chinese populations in Guangdong, China-
dc.typeArticle-
dc.identifier.emailJiang, C: cqjiang@hkucc.hku.hk-
dc.identifier.emailXu, L: linxu@hku.hk-
dc.identifier.emailZhang, W: zhangws9@hku.hk-
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.authorityXu, L=rp02030-
dc.identifier.authorityLam, TH=rp00326-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1136/bmjopen-2019-028968-
dc.identifier.pmid32690726-
dc.identifier.pmcidPMC7375506-
dc.identifier.scopuseid_2-s2.0-85088481340-
dc.identifier.hkuros311869-
dc.identifier.volume10-
dc.identifier.issue7-
dc.identifier.spagearticle no. e028968-
dc.identifier.epagearticle no. e028968-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats