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Article: Dynamic evolution of COVID-19 on chest computed tomography: experience from Jiangsu Province of China

TitleDynamic evolution of COVID-19 on chest computed tomography: experience from Jiangsu Province of China
Authors
KeywordsCoronavirus
Multidetector computed tomography
Viral pneumonia
Issue Date2020
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00330/index.htm
Citation
European Radiology, 2020, Epub 2020-06-10 How to Cite?
AbstractObjectives: To determine the patterns of chest computed tomography (CT) evolution according to disease severity in a large coronavirus disease 2019 (COVID-19) cohort in Jiangsu Province, China. Methods: This retrospective cohort study was conducted from January 10, 2020, to February 18, 2020. All patients diagnosed with COVID-19 in Jiangsu Province were included, retrospectively. Quantitative CT measurements of pulmonary opacities including volume, density, and location were extracted by deep learning algorithm. Dynamic evolution of these measurements was investigated from symptom onset (day 1) to beyond day 15. Comparison was made between severity groups. Results: A total of 484 patients (median age of 47 years, interquartile range 33–57) with 954 CT examinations were included, and each was assigned to one of the three groups: asymptomatic/mild (n = 63), moderate (n = 378), severe/critically ill (n = 43). Time series showed different evolution patterns of CT measurements in the groups. Following disease onset, posteroinferior subpleural area of the lung was the most common location for pulmonary opacities. Opacity volume continued to increase beyond 15 days in the severe/critically ill group, compared with peaking on days 13–15 in the moderate group. Asymptomatic/mild group had the lowest opacity volume which almost resolved after 15 days. The opacity density began to drop from day 10 to day 12 for moderately ill patients. Conclusions: Volume, density, and location of the pulmonary opacity and their evolution on CT varied with disease severity in COVID-19. These findings are valuable in understanding the nature of the disease and monitoring the patient’s condition during the course of illness.
Persistent Identifierhttp://hdl.handle.net/10722/284272
ISSN
2019 Impact Factor: 4.101
2015 SCImago Journal Rankings: 2.064
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorWANG, YC-
dc.contributor.authorLUO, H-
dc.contributor.authorLIU, S-
dc.contributor.authorHUANG, S-
dc.contributor.authorZHOU, Z-
dc.contributor.authorYU, Q-
dc.contributor.authorZHANG, S-
dc.contributor.authorZHAO, Z-
dc.contributor.authorYu, Y-
dc.contributor.authorYANG, Y-
dc.contributor.authorWANG, D-
dc.contributor.authorJU, S-
dc.date.accessioned2020-07-20T05:57:25Z-
dc.date.available2020-07-20T05:57:25Z-
dc.date.issued2020-
dc.identifier.citationEuropean Radiology, 2020, Epub 2020-06-10-
dc.identifier.issn0938-7994-
dc.identifier.urihttp://hdl.handle.net/10722/284272-
dc.description.abstractObjectives: To determine the patterns of chest computed tomography (CT) evolution according to disease severity in a large coronavirus disease 2019 (COVID-19) cohort in Jiangsu Province, China. Methods: This retrospective cohort study was conducted from January 10, 2020, to February 18, 2020. All patients diagnosed with COVID-19 in Jiangsu Province were included, retrospectively. Quantitative CT measurements of pulmonary opacities including volume, density, and location were extracted by deep learning algorithm. Dynamic evolution of these measurements was investigated from symptom onset (day 1) to beyond day 15. Comparison was made between severity groups. Results: A total of 484 patients (median age of 47 years, interquartile range 33–57) with 954 CT examinations were included, and each was assigned to one of the three groups: asymptomatic/mild (n = 63), moderate (n = 378), severe/critically ill (n = 43). Time series showed different evolution patterns of CT measurements in the groups. Following disease onset, posteroinferior subpleural area of the lung was the most common location for pulmonary opacities. Opacity volume continued to increase beyond 15 days in the severe/critically ill group, compared with peaking on days 13–15 in the moderate group. Asymptomatic/mild group had the lowest opacity volume which almost resolved after 15 days. The opacity density began to drop from day 10 to day 12 for moderately ill patients. Conclusions: Volume, density, and location of the pulmonary opacity and their evolution on CT varied with disease severity in COVID-19. These findings are valuable in understanding the nature of the disease and monitoring the patient’s condition during the course of illness.-
dc.languageeng-
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00330/index.htm-
dc.relation.ispartofEuropean Radiology-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: http://dx.doi.org/[insert DOI]-
dc.subjectCoronavirus-
dc.subjectMultidetector computed tomography-
dc.subjectViral pneumonia-
dc.titleDynamic evolution of COVID-19 on chest computed tomography: experience from Jiangsu Province of China-
dc.typeArticle-
dc.identifier.emailYu, Y: yzyu@cs.hku.hk-
dc.identifier.authorityYu, Y=rp01415-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1007/s00330-020-06976-6-
dc.identifier.pmid32524223-
dc.identifier.pmcidPMC7283983-
dc.identifier.scopuseid_2-s2.0-85086398608-
dc.identifier.hkuros310938-
dc.identifier.volumeEpub 2020-06-10-
dc.publisher.placeGermany-

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