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Article: Non-enzymatic oxygenated metabolite of docosahexaenoic acid, 4(RS)-4-F4t-neuroprostane, acts as a bioactive lipid molecule in neuronal cells

TitleNon-enzymatic oxygenated metabolite of docosahexaenoic acid, 4(RS)-4-F4t-neuroprostane, acts as a bioactive lipid molecule in neuronal cells
Authors
Keywordsisoprostanes
neuroprostanes
neuroblastoma
omega‐3 lipids
4‐HHE
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
FEBS Letters, 2020, Epub 2020-03-25 How to Cite?
AbstractDocosahexaenoic acid (DHA), an abundant fatty acid in the brain, is susceptible to autooxidation in situ and releases metabolites such as F4‐neuroprostane (4‐F4t‐NeuroP). The presence of 4‐F4t‐NeuroP in the brain is not well explored. In this study, 4‐F4t‐NeuroP was introduced into neuroblastoma cells (SH‐SY5Y) and, by in vivo infusion, into rodents. Targeted lipidomic analysis of liver and brain tissues show significant elevation of anti‐inflammatory hydroxylated‐DHA metabolites and an isomer of neuroprotectin D1, suggesting potential beneficial bioactivities of 4‐F4t‐NeuroP. Additionally, 4‐F4t‐NeuroP treatment in SH‐SY5Y cells and primary neuronal culture consistently upregulates the transcriptional level of the antioxidant enzyme hemeoxygenase‐1, but the effect is reduced when 4‐F4t‐NeuroP is further oxidized. Our data suggest that 4‐F4t‐NeuroP could be neuroprotective in the native state but may have disadvantageous bioactivity when oxidized extensively.
Persistent Identifierhttp://hdl.handle.net/10722/281920
ISSN
2019 Impact Factor: 3.057
2015 SCImago Journal Rankings: 2.026

 

DC FieldValueLanguage
dc.contributor.authorLEE, YY-
dc.contributor.authorGalano, J-M-
dc.contributor.authorLEUNG, HH-
dc.contributor.authorBalas, L-
dc.contributor.authorOger, C-
dc.contributor.authorDurand, T-
dc.contributor.authorLee, JC-Y-
dc.date.accessioned2020-04-03T07:23:39Z-
dc.date.available2020-04-03T07:23:39Z-
dc.date.issued2020-
dc.identifier.citationFEBS Letters, 2020, Epub 2020-03-25-
dc.identifier.issn0014-5793-
dc.identifier.urihttp://hdl.handle.net/10722/281920-
dc.description.abstractDocosahexaenoic acid (DHA), an abundant fatty acid in the brain, is susceptible to autooxidation in situ and releases metabolites such as F4‐neuroprostane (4‐F4t‐NeuroP). The presence of 4‐F4t‐NeuroP in the brain is not well explored. In this study, 4‐F4t‐NeuroP was introduced into neuroblastoma cells (SH‐SY5Y) and, by in vivo infusion, into rodents. Targeted lipidomic analysis of liver and brain tissues show significant elevation of anti‐inflammatory hydroxylated‐DHA metabolites and an isomer of neuroprotectin D1, suggesting potential beneficial bioactivities of 4‐F4t‐NeuroP. Additionally, 4‐F4t‐NeuroP treatment in SH‐SY5Y cells and primary neuronal culture consistently upregulates the transcriptional level of the antioxidant enzyme hemeoxygenase‐1, but the effect is reduced when 4‐F4t‐NeuroP is further oxidized. Our data suggest that 4‐F4t‐NeuroP could be neuroprotective in the native state but may have disadvantageous bioactivity when oxidized extensively.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet-
dc.relation.ispartofFEBS Letters-
dc.subjectisoprostanes-
dc.subjectneuroprostanes-
dc.subjectneuroblastoma-
dc.subjectomega‐3 lipids-
dc.subject4‐HHE-
dc.titleNon-enzymatic oxygenated metabolite of docosahexaenoic acid, 4(RS)-4-F4t-neuroprostane, acts as a bioactive lipid molecule in neuronal cells-
dc.typeArticle-
dc.identifier.emailLee, JC-Y: jettylee@hku.hk-
dc.identifier.authorityLee, JC-Y=rp01511-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/1873-3468.13774-
dc.identifier.scopuseid_2-s2.0-85083090447-
dc.identifier.hkuros309683-
dc.identifier.volumeEpub 2020-03-25-
dc.publisher.placeNetherlands-

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