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Article: TISIDB: an integrated repository portal for tumor–immune system interactions

TitleTISIDB: an integrated repository portal for tumor–immune system interactions
Authors
KeywordsGenes
Computational Biology
Pathway enrichment
Issue Date2019
PublisherOxford University Press (OUP): Policy B - Oxford Open Option B. The Journal's web site is located at http://bioinformatics.oxfordjournals.org/
Citation
Bioinformatics, 2019, v. 35 n. 20, p. 4200-4202 How to Cite?
AbstractThe interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor–immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor–immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication.
Persistent Identifierhttp://hdl.handle.net/10722/280113
ISSN
2017 Impact Factor: 5.481
2015 SCImago Journal Rankings: 4.643

 

DC FieldValueLanguage
dc.contributor.authorRU, B-
dc.contributor.authorWong, CN-
dc.contributor.authorTong, Y-
dc.contributor.authorZhong, JY-
dc.contributor.authorZhong, SSW-
dc.contributor.authorWu, WC-
dc.contributor.authorChu, KC-
dc.contributor.authorWong, CY-
dc.contributor.authorLau, CY-
dc.contributor.authorChen, I-
dc.contributor.authorChan, NW-
dc.contributor.authorZhang, J-
dc.date.accessioned2020-01-06T02:01:09Z-
dc.date.available2020-01-06T02:01:09Z-
dc.date.issued2019-
dc.identifier.citationBioinformatics, 2019, v. 35 n. 20, p. 4200-4202-
dc.identifier.issn1367-4803-
dc.identifier.urihttp://hdl.handle.net/10722/280113-
dc.description.abstractThe interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor–immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor–immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication.-
dc.languageeng-
dc.publisherOxford University Press (OUP): Policy B - Oxford Open Option B. The Journal's web site is located at http://bioinformatics.oxfordjournals.org/-
dc.relation.ispartofBioinformatics-
dc.subjectGenes-
dc.subjectComputational Biology-
dc.subjectPathway enrichment-
dc.titleTISIDB: an integrated repository portal for tumor–immune system interactions-
dc.typeArticle-
dc.identifier.emailTong, Y: tongyin9@hku.hk-
dc.identifier.emailZhang, J: jzhang1@hku.hk-
dc.identifier.authorityZhang, J=rp01713-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/bioinformatics/btz210-
dc.identifier.pmid30903160-
dc.identifier.scopuseid_2-s2.0-85071048049-
dc.identifier.hkuros308894-
dc.identifier.volume35-
dc.identifier.issue20-
dc.identifier.spage4200-
dc.identifier.epage4202-
dc.publisher.placeUnited Kingdom-

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