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Article: Enriched Environment And Effects On Neuropathic Pain: Experimental Findings And Mechanisms

TitleEnriched Environment And Effects On Neuropathic Pain: Experimental Findings And Mechanisms
Authors
Keywordsenvironmental enrichment
neuropathic pain
neuroprotection
neuroplasticity
exercise
Issue Date2018
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1533-2500
Citation
Pain Practice, 2018, v. 18 n. 8, p. 1068-1082 How to Cite?
AbstractNeuropathic pain inflicts tremendous biopsychosocial suffering for patients worldwide. However, safe and effective treatment of neuropathic pain is a prominent unmet clinical need. Environmental enrichment (EE) is an emerging cost‐effective nonpharmacological approach to alleviate neuropathic pain and complement rehabilitation care. We present here a review of preclinical studies in ascertaining the efficacy of EE for neuropathic pain. Their proposed mechanisms, including the suppression of ascending nociceptive signaling to the brain, enhancement of the descending inhibitory system, and neuroprotection of the peripheral and central nervous systems, may collectively reduce pain perception and improve somatic and emotional functioning in neuropathic pain. The current evidence offers critical insights for future preclinical research and the translational application of EE in clinical pain management.
Persistent Identifierhttp://hdl.handle.net/10722/279446
ISSN
2019 Impact Factor: 2.258
2015 SCImago Journal Rankings: 0.659

 

DC FieldValueLanguage
dc.contributor.authorTAI, LW-
dc.contributor.authorYeung, SC-
dc.contributor.authorCheung, CW-
dc.date.accessioned2019-11-01T07:17:31Z-
dc.date.available2019-11-01T07:17:31Z-
dc.date.issued2018-
dc.identifier.citationPain Practice, 2018, v. 18 n. 8, p. 1068-1082-
dc.identifier.issn1530-7085-
dc.identifier.urihttp://hdl.handle.net/10722/279446-
dc.description.abstractNeuropathic pain inflicts tremendous biopsychosocial suffering for patients worldwide. However, safe and effective treatment of neuropathic pain is a prominent unmet clinical need. Environmental enrichment (EE) is an emerging cost‐effective nonpharmacological approach to alleviate neuropathic pain and complement rehabilitation care. We present here a review of preclinical studies in ascertaining the efficacy of EE for neuropathic pain. Their proposed mechanisms, including the suppression of ascending nociceptive signaling to the brain, enhancement of the descending inhibitory system, and neuroprotection of the peripheral and central nervous systems, may collectively reduce pain perception and improve somatic and emotional functioning in neuropathic pain. The current evidence offers critical insights for future preclinical research and the translational application of EE in clinical pain management.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1533-2500-
dc.relation.ispartofPain Practice-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectenvironmental enrichment-
dc.subjectneuropathic pain-
dc.subjectneuroprotection-
dc.subjectneuroplasticity-
dc.subjectexercise-
dc.titleEnriched Environment And Effects On Neuropathic Pain: Experimental Findings And Mechanisms-
dc.typeArticle-
dc.identifier.emailCheung, CW: cheucw@hku.hk-
dc.identifier.authorityCheung, CW=rp00244-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/papr.12706-
dc.identifier.pmid29722923-
dc.identifier.scopuseid_2-s2.0-85056582734-
dc.identifier.hkuros308623-
dc.identifier.volume18-
dc.identifier.issue8-
dc.identifier.spage1068-
dc.identifier.epage1082-
dc.publisher.placeUnited States-

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