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Article: Zinc-Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration

TitleZinc-Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration
Authors
Keywordsbone formation
immunomodulation
macrophages
stem cells
zinc
Issue Date2018
PublisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844
Citation
Advanced Science, 2018, v. 5 n. 10, p. article no. 1800749 How to Cite?
AbstractThe cytokines released by immune cells are considered important factors to induce bone tissue regeneration. However, the pathway of those bone‐targeting macrophage cytokines induced by biomaterial surface under tissue microenvironment is rarely reported. In this study, the immunomodulatory capability of zinc ions on macrophage polarization and its effects on osteogenic differentiation are investigated. Hence, a layer of zinc ions are incorporated on sulfonated polyetheretherketone (SPEEK) biomaterials by using a customized magnetron sputtering technique. The results reveal that the microenvironment on Zn‐coated SPEEK can modulate nonactivated macrophage polarization to an anti‐inflammatory phenotype and induce the secretion of anti‐inflammatory and osteogenic cytokines. The osteogenic differentiation capability of bone marrow stromal cells (BMSCs) is therefore enhanced, leading to improved osteointegration between the zinc‐coated SPEEK and bone tissue. This study verifies that zinc ion is a promising additive in the osteoimmunomodulation process and provides knowledge that may pave the way to develop the next generation of immunomodulatory biomaterials.
Persistent Identifierhttp://hdl.handle.net/10722/278229
ISSN
2017 Impact Factor: 12.441

 

DC FieldValueLanguage
dc.contributor.authorLIU, W-
dc.contributor.authorLI, J-
dc.contributor.authorCHENG, M-
dc.contributor.authorWANG, Q-
dc.contributor.authorYeung, KWK-
dc.contributor.authorCHU, PK-
dc.contributor.authorZHANG, X-
dc.date.accessioned2019-10-04T08:09:58Z-
dc.date.available2019-10-04T08:09:58Z-
dc.date.issued2018-
dc.identifier.citationAdvanced Science, 2018, v. 5 n. 10, p. article no. 1800749-
dc.identifier.issn2198-3844-
dc.identifier.urihttp://hdl.handle.net/10722/278229-
dc.description.abstractThe cytokines released by immune cells are considered important factors to induce bone tissue regeneration. However, the pathway of those bone‐targeting macrophage cytokines induced by biomaterial surface under tissue microenvironment is rarely reported. In this study, the immunomodulatory capability of zinc ions on macrophage polarization and its effects on osteogenic differentiation are investigated. Hence, a layer of zinc ions are incorporated on sulfonated polyetheretherketone (SPEEK) biomaterials by using a customized magnetron sputtering technique. The results reveal that the microenvironment on Zn‐coated SPEEK can modulate nonactivated macrophage polarization to an anti‐inflammatory phenotype and induce the secretion of anti‐inflammatory and osteogenic cytokines. The osteogenic differentiation capability of bone marrow stromal cells (BMSCs) is therefore enhanced, leading to improved osteointegration between the zinc‐coated SPEEK and bone tissue. This study verifies that zinc ion is a promising additive in the osteoimmunomodulation process and provides knowledge that may pave the way to develop the next generation of immunomodulatory biomaterials.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844-
dc.relation.ispartofAdvanced Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbone formation-
dc.subjectimmunomodulation-
dc.subjectmacrophages-
dc.subjectstem cells-
dc.subjectzinc-
dc.titleZinc-Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration-
dc.typeArticle-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/advs.201800749-
dc.identifier.scopuseid_2-s2.0-85052475967-
dc.identifier.hkuros306875-
dc.identifier.volume5-
dc.identifier.issue10-
dc.identifier.spagearticle no. 1800749-
dc.identifier.epagearticle no. 1800749-
dc.publisher.placeGermany-

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