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Article: Congenital urinary tract obstruction

TitleCongenital urinary tract obstruction
Authors
KeywordsCongenital abnormalities
Fetal therapy
Prenatal ultrasonography
Urinary bladder neck obstruction
Issue Date2019
PublisherBailliere Tindall. The Journal's web site is located at http://www.elsevier.com/locate/bpobgyn
Citation
Best Practice & Research: Clinical Obstetrics & Gynaecology, 2019, v. 58, p. 78-92 How to Cite?
AbstractCongenital bladder neck obstruction (or lower urinary tract obstruction [LUTO]) describes a heterogeneous group of congenital anomalies presenting with similar prenatal ultrasonographic findings of dilated posterior urethra, megacystis, hydronephrosis, oligohydramnios and often with associated renal dysplasia. Untreated LUTO has high rate of perinatal morbidity and mortality from associated pulmonary hypoplasia and early-onset renal failure in infancy. Ultrasonographic features and prospective fetal urinalysis may help in predicting the overall prognosis of congenital LUTO. Currently, fetal vesicoamniotic shunt (of various designs), and fetal cystoscopy and fulguration of the obstruction are potential prenatal interventions. Retrospective and prospective cohort studies and a relatively small randomized controlled trial have demonstrated these treatments may possibly improve perinatal survival. Despite this, concerns remain as to the high rates of renal impairment observed in paediatric survivors. A clinical prospective scoring/staging system may improve prenatal diagnostic criteria and case selection for fetal therapy.
Persistent Identifierhttp://hdl.handle.net/10722/277777
ISSN
2017 Impact Factor: 2.71
2015 SCImago Journal Rankings: 1.123

 

DC FieldValueLanguage
dc.contributor.authorCheung, KW-
dc.contributor.authorMorris, RK-
dc.contributor.authorKilby, MD-
dc.date.accessioned2019-10-04T08:01:09Z-
dc.date.available2019-10-04T08:01:09Z-
dc.date.issued2019-
dc.identifier.citationBest Practice & Research: Clinical Obstetrics & Gynaecology, 2019, v. 58, p. 78-92-
dc.identifier.issn1521-6934-
dc.identifier.urihttp://hdl.handle.net/10722/277777-
dc.description.abstractCongenital bladder neck obstruction (or lower urinary tract obstruction [LUTO]) describes a heterogeneous group of congenital anomalies presenting with similar prenatal ultrasonographic findings of dilated posterior urethra, megacystis, hydronephrosis, oligohydramnios and often with associated renal dysplasia. Untreated LUTO has high rate of perinatal morbidity and mortality from associated pulmonary hypoplasia and early-onset renal failure in infancy. Ultrasonographic features and prospective fetal urinalysis may help in predicting the overall prognosis of congenital LUTO. Currently, fetal vesicoamniotic shunt (of various designs), and fetal cystoscopy and fulguration of the obstruction are potential prenatal interventions. Retrospective and prospective cohort studies and a relatively small randomized controlled trial have demonstrated these treatments may possibly improve perinatal survival. Despite this, concerns remain as to the high rates of renal impairment observed in paediatric survivors. A clinical prospective scoring/staging system may improve prenatal diagnostic criteria and case selection for fetal therapy.-
dc.languageeng-
dc.publisherBailliere Tindall. The Journal's web site is located at http://www.elsevier.com/locate/bpobgyn-
dc.relation.ispartofBest Practice & Research: Clinical Obstetrics & Gynaecology-
dc.subjectCongenital abnormalities-
dc.subjectFetal therapy-
dc.subjectPrenatal ultrasonography-
dc.subjectUrinary bladder neck obstruction-
dc.titleCongenital urinary tract obstruction-
dc.typeArticle-
dc.identifier.emailCheung, KW: kawang@HKUCC-COM.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bpobgyn.2019.01.003-
dc.identifier.pmid30819578-
dc.identifier.scopuseid_2-s2.0-85061980593-
dc.identifier.hkuros306800-
dc.identifier.volume58-
dc.identifier.spage78-
dc.identifier.epage92-
dc.publisher.placeUnited Kingdom-

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