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Article: The effect of rupture of membranes and labour on the risk of hepatitis B vertical transmission: Prospective multicentre observational study

TitleThe effect of rupture of membranes and labour on the risk of hepatitis B vertical transmission: Prospective multicentre observational study
Authors
Cheung, KWSeto, MTYSo, PLWong, DMak, ASLLau, WLWang, WKan, ASYLee, CPNg, EHY
KeywordsHepatitis B virus
Immunoprophylaxis failure
Labour
Pregnancy
Rupture of membranes
Issue Date2019
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
Citation
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2019, v. 232, p. 97-100 How to Cite?
DOI: http://dx.doi.org/10.1016/j.ejogrb.2018.11.017
AbstractObjective: To evaluate the effect of rupture of membranes and labour on the risk of hepatitis B virus (HBV) vertical transmission. Study design: A prospective multicentre observational study was carried out in Hong Kong between 2014-2016. Pregnant HBV carriers were recruited. The duration of rupture of membranes, labour and mode of delivery were collected prospectively. HBV DNA was examined at 28–30 weeks of gestation. All newborns received standard HBV vaccination and immunoglobulin. Hepatitis B surface antigen of infants was tested at 9–12 months of age. Results: 641 pregnancies were recruited and analyzed. No statistically significant difference was found in gravida, parity, gestational age at delivery, mode of delivery, duration of rupture of membranes, duration of labour, preterm delivery, preterm rupture of membranes or birth weight (p > 0.05). Subgroup analysis in viral load > 7log10IU/ml and 8log10IU/ml also did not find a significant association between duration of rupture of membranes and labour with immunoprophylaxis failure. Conclusions: Duration of rupture of membranes and labour would not affect the risk of HBV vertical transmission in infants following standard HBV vaccination and hepatitis B immunoglobulin administration.
Persistent Identifierhttp://hdl.handle.net/10722/277771
ISSN
0301-2115
2021 Impact Factor: 2.831
2020 SCImago Journal Rankings: 0.842
ISI Accession Number ID
WOS:000455559300017

 

DC FieldValueLanguage
dc.contributor.authorCheung, KW-
dc.contributor.authorSeto, MTY-
dc.contributor.authorSo, PL-
dc.contributor.authorWong, D-
dc.contributor.authorMak, ASL-
dc.contributor.authorLau, WL-
dc.contributor.authorWang, W-
dc.contributor.authorKan, ASY-
dc.contributor.authorLee, CP-
dc.contributor.authorNg, EHY-
dc.date.accessioned2019-10-04T08:01:01Z-
dc.date.available2019-10-04T08:01:01Z-
dc.date.issued2019-
dc.identifier.citationEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2019, v. 232, p. 97-100-
dc.identifier.issn0301-2115-
dc.identifier.urihttp://hdl.handle.net/10722/277771-
dc.description.abstractObjective: To evaluate the effect of rupture of membranes and labour on the risk of hepatitis B virus (HBV) vertical transmission. Study design: A prospective multicentre observational study was carried out in Hong Kong between 2014-2016. Pregnant HBV carriers were recruited. The duration of rupture of membranes, labour and mode of delivery were collected prospectively. HBV DNA was examined at 28–30 weeks of gestation. All newborns received standard HBV vaccination and immunoglobulin. Hepatitis B surface antigen of infants was tested at 9–12 months of age. Results: 641 pregnancies were recruited and analyzed. No statistically significant difference was found in gravida, parity, gestational age at delivery, mode of delivery, duration of rupture of membranes, duration of labour, preterm delivery, preterm rupture of membranes or birth weight (p > 0.05). Subgroup analysis in viral load > 7log10IU/ml and 8log10IU/ml also did not find a significant association between duration of rupture of membranes and labour with immunoprophylaxis failure. Conclusions: Duration of rupture of membranes and labour would not affect the risk of HBV vertical transmission in infants following standard HBV vaccination and hepatitis B immunoglobulin administration.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb-
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHepatitis B virus-
dc.subjectImmunoprophylaxis failure-
dc.subjectLabour-
dc.subjectPregnancy-
dc.subjectRupture of membranes-
dc.titleThe effect of rupture of membranes and labour on the risk of hepatitis B vertical transmission: Prospective multicentre observational study-
dc.typeArticle-
dc.identifier.emailCheung, KW: kawang@HKUCC-COM.hku.hk-
dc.identifier.emailSeto, MTY: mimiseto@HKUCC-COM.hku.hk-
dc.identifier.emailMak, ASL: makasl@HKUCC-COM.hku.hk-
dc.identifier.emailLau, WL: lauwl@hkucc.hku.hk-
dc.identifier.emailKan, ASY: kansya@hkucc.hku.hk-
dc.identifier.emailLee, CP: chinpeng@hkucc.hku.hk-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.authorityLee, CP=rp01862-
dc.identifier.authorityNg, EHY=rp00426-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.ejogrb.2018.11.017-
dc.identifier.pmid30504033-
dc.identifier.scopuseid_2-s2.0-85057477736-
dc.identifier.hkuros306689-
dc.identifier.volume232-
dc.identifier.spage97-
dc.identifier.epage100-
dc.identifier.isiWOS:000455559300017-
dc.publisher.placeIreland-
dc.identifier.issnl0301-2115-

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