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Article: Management of locally recurrent nasopharyngeal carcinoma

TitleManagement of locally recurrent nasopharyngeal carcinoma
Authors
KeywordsNasopharyngeal carcinoma
Recurrent
Nasopharyngectomy
Radiotherapy
Prognostic factor
Issue Date2019
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ctrv
Citation
Cancer Treatment Reviews, 2019, v. 79, p. article no. 101890 How to Cite?
AbstractAs a consequence of the current excellent loco-regional control rates attained using the generally accepted treatment paradigms involving intensity-modulated radiotherapy for nasopharyngeal carcinoma (NPC), only 10–20% of patients will suffer from local and/or nodal recurrence after primary treatment. Early detection of recurrence is important as localized recurrent disease is still potentially salvageable, but this treatment often incurs a high risk of major toxicities. Due to the possibility of radio-resistance of tumors which persist or recur despite adequate prior irradiation and the limited tolerance of adjacent normal tissues to sustain further additional treatment, the management of local failures remains one of the greatest challenges in this disease. Both surgical approaches for radical resection and specialized re-irradiation modalities have been explored. Unfortunately, available data are based on retrospective studies, and the majority of them are based on a small number of patients or relatively short follow-up. In this article, we will review the different salvage treatment options and associated prognostic factors for each of them. We will also propose a treatment algorithm based on the latest available evidence and discuss the future directions of treatment for locally recurrent NPC.
Persistent Identifierhttp://hdl.handle.net/10722/277213
ISSN
2017 Impact Factor: 8.122
2015 SCImago Journal Rankings: 3.284

 

DC FieldValueLanguage
dc.contributor.authorLee, AWM-
dc.contributor.authorNg, WT-
dc.contributor.authorChan, JYW-
dc.contributor.authorCorry, J-
dc.contributor.authorMäkitie, A-
dc.contributor.authorMendenhall, MW-
dc.contributor.authorRinaldo, A-
dc.contributor.authorRodrigo, JP-
dc.contributor.authorSaba, NF-
dc.contributor.authorStrojan, P-
dc.contributor.authorSuárez, C-
dc.contributor.authorVermorken, JB-
dc.contributor.authorYom, SS-
dc.contributor.authorFerlito, A-
dc.date.accessioned2019-09-20T08:46:47Z-
dc.date.available2019-09-20T08:46:47Z-
dc.date.issued2019-
dc.identifier.citationCancer Treatment Reviews, 2019, v. 79, p. article no. 101890-
dc.identifier.issn0305-7372-
dc.identifier.urihttp://hdl.handle.net/10722/277213-
dc.description.abstractAs a consequence of the current excellent loco-regional control rates attained using the generally accepted treatment paradigms involving intensity-modulated radiotherapy for nasopharyngeal carcinoma (NPC), only 10–20% of patients will suffer from local and/or nodal recurrence after primary treatment. Early detection of recurrence is important as localized recurrent disease is still potentially salvageable, but this treatment often incurs a high risk of major toxicities. Due to the possibility of radio-resistance of tumors which persist or recur despite adequate prior irradiation and the limited tolerance of adjacent normal tissues to sustain further additional treatment, the management of local failures remains one of the greatest challenges in this disease. Both surgical approaches for radical resection and specialized re-irradiation modalities have been explored. Unfortunately, available data are based on retrospective studies, and the majority of them are based on a small number of patients or relatively short follow-up. In this article, we will review the different salvage treatment options and associated prognostic factors for each of them. We will also propose a treatment algorithm based on the latest available evidence and discuss the future directions of treatment for locally recurrent NPC.-
dc.languageeng-
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ctrv-
dc.relation.ispartofCancer Treatment Reviews-
dc.subjectNasopharyngeal carcinoma-
dc.subjectRecurrent-
dc.subjectNasopharyngectomy-
dc.subjectRadiotherapy-
dc.subjectPrognostic factor-
dc.titleManagement of locally recurrent nasopharyngeal carcinoma-
dc.typeArticle-
dc.identifier.emailLee, AWM: awmlee@hkucc.hku.hk-
dc.identifier.emailChan, JYW: jywchan1@HKUCC-COM.hku.hk-
dc.identifier.authorityLee, AWM=rp02056-
dc.identifier.authorityChan, JYW=rp01314-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ctrv.2019.101890-
dc.identifier.pmid31470314-
dc.identifier.scopuseid_2-s2.0-85071275216-
dc.identifier.hkuros305494-
dc.identifier.volume79-
dc.identifier.spagearticle no. 101890-
dc.identifier.epagearticle no. 101890-
dc.publisher.placeUnited Kingdom-

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