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Conference Paper: Validation of TPPM Score in Predicting Short-Term Survival in HBV-ACLF Patients: A Multinational Study from APASL ACLF Research Consortium (AARC)

TitleValidation of TPPM Score in Predicting Short-Term Survival in HBV-ACLF Patients: A Multinational Study from APASL ACLF Research Consortium (AARC)
Authors
Issue Date2018
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
The Liver Meeting 2018, American Association for the Study of Liver Diseases (AASLD), San Francisco, USA, 9-13 November 2018. Abstracts in Hepatology, 2018, v. 68 n. Suppl. 1, p. 193A-194A, abstract no. 318 How to Cite?
AbstractBackground: Tongji prognostic predictor model (TPPM) for HBV- ACLF, includes bilirubin (TBIL), INR, number of complications and HBV DNA and has been validated for its predictive value from a single center. In the present study, we compared TPPM with AARC score, MELDMELD-Na, CLIF-C OF and CLIF-C ACLF in predicting 28 and 90 days mortality in patients with HBV-ACLF. Methods: 606 HBV-ACLF patients defined by the AARC criteria from the AARC database, gathered from 12 Asian-Pacific countries, were enrolled in the study. Patients were stratified by cirrhosis and CLIF-C criteria. The prognostic performance for 28 and 90 days mortality were compared by area under the receiver operating characteristic curves (AUROC). Results: Among total 606 patients, 375 (61.88%) patients had cirrhosis. In the cirrhotic and noncirrhotic patients,150 and 79 patients met CLIF-C criteria respectively. The 28 and 90 days mortality of patients defined by CLIF-C criteria were significantly higher than those who did not satisfy the CLIF-C criteria. As ACLF grades increased, survival rates became significantly lower. Among total patients, AUROC of the TPPM (0.837, 0.780) was higher than MELD (0.755, 0.711), MELD-Na (0.753, 0.723), AARC (0.790, 0.776), CLIF-C OF (0.832, 0.783) and CLIF-C ACLF (0.796, 0.742) in predicting 28 and 90 days mortality respectively. With a cutoff value of 0.28 for 90 days mortality, the TPPM positive and negative predictive values were 52.43% and 85.73% respectively. Among cirrhotic patients, AUROC of the TPPM (0.854, 0.762) was higher than MELD (0.757, 0.697), MELDNa (0.753, 0.709), AARC (0.802, 0.780), CLIF-C OF (0.812, 0.749) and CLIF-C ACLF (0.753, 0.711) in predicting 28 and 90 days mortality respectively. With a cut-off value of 0.28, the TPPM positive and negative prediction values were 56.20% and 83.20% for 90 days mortality respectively. Conclusion: The TPPM scoring system possesses higher predicting ability in HBV-ACLF patients when compared with MELD, MELDNa, AARC, CLIF-C OF and CLIF-C ACLF.
DescriptionPoster Presentation - no. 318
Persistent Identifierhttp://hdl.handle.net/10722/275859
ISSN
2017 Impact Factor: 14.079
2015 SCImago Journal Rankings: 4.752

 

DC FieldValueLanguage
dc.contributor.authorChen, T-
dc.contributor.authorMa, K-
dc.contributor.authorYang, ZY-
dc.contributor.authorDuan, Z-
dc.contributor.authorLi, J-
dc.contributor.authorChen, Y-
dc.contributor.authorHan, T-
dc.contributor.authorHu, J-
dc.contributor.authorChoudhury, AK-
dc.contributor.authorMahtab, MA-
dc.contributor.authorXin, S-
dc.contributor.authorNan, Y-
dc.contributor.authorTan, SS-
dc.contributor.authorHamid, SS-
dc.contributor.authorJafri, SMW-
dc.contributor.authorButt, A-
dc.contributor.authorLee, GH-
dc.contributor.authorGhazinian, H-
dc.contributor.authorChawla, YK-
dc.contributor.authorYuen, RMF-
dc.contributor.authorJia, .J-
dc.contributor.authorAbbas, Z-
dc.contributor.authorDevarbhavi, H-
dc.contributor.authorDokmeci, A-
dc.contributor.authorAmarapurkar, DN-
dc.contributor.authorLesmana, LA-
dc.contributor.authorLau, GKK-
dc.contributor.authorYokosuka, O-
dc.contributor.authorGuo, W-
dc.contributor.authorSarin, SK-
dc.contributor.authorNing, Q-
dc.contributor.authorAPASL ACLF working party,-
dc.date.accessioned2019-09-10T02:51:06Z-
dc.date.available2019-09-10T02:51:06Z-
dc.date.issued2018-
dc.identifier.citationThe Liver Meeting 2018, American Association for the Study of Liver Diseases (AASLD), San Francisco, USA, 9-13 November 2018. Abstracts in Hepatology, 2018, v. 68 n. Suppl. 1, p. 193A-194A, abstract no. 318-
dc.identifier.issn0270-9139-
dc.identifier.urihttp://hdl.handle.net/10722/275859-
dc.descriptionPoster Presentation - no. 318-
dc.description.abstractBackground: Tongji prognostic predictor model (TPPM) for HBV- ACLF, includes bilirubin (TBIL), INR, number of complications and HBV DNA and has been validated for its predictive value from a single center. In the present study, we compared TPPM with AARC score, MELDMELD-Na, CLIF-C OF and CLIF-C ACLF in predicting 28 and 90 days mortality in patients with HBV-ACLF. Methods: 606 HBV-ACLF patients defined by the AARC criteria from the AARC database, gathered from 12 Asian-Pacific countries, were enrolled in the study. Patients were stratified by cirrhosis and CLIF-C criteria. The prognostic performance for 28 and 90 days mortality were compared by area under the receiver operating characteristic curves (AUROC). Results: Among total 606 patients, 375 (61.88%) patients had cirrhosis. In the cirrhotic and noncirrhotic patients,150 and 79 patients met CLIF-C criteria respectively. The 28 and 90 days mortality of patients defined by CLIF-C criteria were significantly higher than those who did not satisfy the CLIF-C criteria. As ACLF grades increased, survival rates became significantly lower. Among total patients, AUROC of the TPPM (0.837, 0.780) was higher than MELD (0.755, 0.711), MELD-Na (0.753, 0.723), AARC (0.790, 0.776), CLIF-C OF (0.832, 0.783) and CLIF-C ACLF (0.796, 0.742) in predicting 28 and 90 days mortality respectively. With a cutoff value of 0.28 for 90 days mortality, the TPPM positive and negative predictive values were 52.43% and 85.73% respectively. Among cirrhotic patients, AUROC of the TPPM (0.854, 0.762) was higher than MELD (0.757, 0.697), MELDNa (0.753, 0.709), AARC (0.802, 0.780), CLIF-C OF (0.812, 0.749) and CLIF-C ACLF (0.753, 0.711) in predicting 28 and 90 days mortality respectively. With a cut-off value of 0.28, the TPPM positive and negative prediction values were 56.20% and 83.20% for 90 days mortality respectively. Conclusion: The TPPM scoring system possesses higher predicting ability in HBV-ACLF patients when compared with MELD, MELDNa, AARC, CLIF-C OF and CLIF-C ACLF.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/-
dc.relation.ispartofHepatology-
dc.relation.ispartofAmerican Association for the Study of Liver Diseases (AASLD): The Liver Meeting 2018-
dc.titleValidation of TPPM Score in Predicting Short-Term Survival in HBV-ACLF Patients: A Multinational Study from APASL ACLF Research Consortium (AARC)-
dc.typeConference_Paper-
dc.identifier.emailYuen, RMF: mfyuen@hku.hk-
dc.identifier.authorityYuen, RMF=rp00479-
dc.identifier.hkuros304586-
dc.identifier.volume68-
dc.identifier.issueSuppl. 1-
dc.identifier.spage193A-
dc.identifier.epage194A-
dc.publisher.placeUnited States-

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