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Article: A survey of recent adenoviral respiratory pathogens in Hong Kong reveals emergent and recombinant human adenovirus type 4 (HAdV-E4) circulating in civilian populations

TitleA survey of recent adenoviral respiratory pathogens in Hong Kong reveals emergent and recombinant human adenovirus type 4 (HAdV-E4) circulating in civilian populations
Authors
KeywordsCivilian populations
Evolution
Genome recombination
Host adaptation
Human adenovirus type 4
Issue Date2019
PublisherMolecular Diversity Preservation International (MDPI) AG.. The Journal's web site is located at http://www.mdpi.com/journal/viruses
Citation
Viruses, 2019, v. 11 n. 2, p. 129 How to Cite?
AbstractHuman adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these “old” HAdV-E4 is the absence of a critical replication motif, NF-I, which is found in all HAdV respiratory pathogens and most HAdVs. However, our recent survey of flu-like disease in children in Hong Kong reveals that the emergent HAdV-E4 pathogens circulating in civilian populations contain NF-I, indicating recombination and reflecting host-adaptation that enables the “new” HAdV-E4 to replicate more efficiently in human cells and foretells more potential HAdV-E4 outbreaks in immune-naïve civilian populations. Special attention should be paid by clinicians to this emergent and recombinant HAdV-E4 circulating in civilian populations. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Persistent Identifierhttp://hdl.handle.net/10722/275138
ISSN
2017 Impact Factor: 3.761
2015 SCImago Journal Rankings: 1.873
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, J-
dc.contributor.authorKang, J-
dc.contributor.authorDehghan, S-
dc.contributor.authorSridhar, S-
dc.contributor.authorLau, SKP-
dc.contributor.authorOu, J-
dc.contributor.authorWoo, PCY-
dc.contributor.authorZhang, Q-
dc.contributor.authorSeto, D-
dc.date.accessioned2019-09-10T02:36:17Z-
dc.date.available2019-09-10T02:36:17Z-
dc.date.issued2019-
dc.identifier.citationViruses, 2019, v. 11 n. 2, p. 129-
dc.identifier.issn1999-4915-
dc.identifier.urihttp://hdl.handle.net/10722/275138-
dc.description.abstractHuman adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these “old” HAdV-E4 is the absence of a critical replication motif, NF-I, which is found in all HAdV respiratory pathogens and most HAdVs. However, our recent survey of flu-like disease in children in Hong Kong reveals that the emergent HAdV-E4 pathogens circulating in civilian populations contain NF-I, indicating recombination and reflecting host-adaptation that enables the “new” HAdV-E4 to replicate more efficiently in human cells and foretells more potential HAdV-E4 outbreaks in immune-naïve civilian populations. Special attention should be paid by clinicians to this emergent and recombinant HAdV-E4 circulating in civilian populations. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International (MDPI) AG.. The Journal's web site is located at http://www.mdpi.com/journal/viruses-
dc.relation.ispartofViruses-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCivilian populations-
dc.subjectEvolution-
dc.subjectGenome recombination-
dc.subjectHost adaptation-
dc.subjectHuman adenovirus type 4-
dc.titleA survey of recent adenoviral respiratory pathogens in Hong Kong reveals emergent and recombinant human adenovirus type 4 (HAdV-E4) circulating in civilian populations-
dc.typeArticle-
dc.identifier.emailSridhar, S: sid8998@hku.hk-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.authoritySridhar, S=rp02249-
dc.identifier.authorityLau, SKP=rp00486-
dc.identifier.authorityWoo, PCY=rp00430-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/v11020129-
dc.identifier.pmid30708990-
dc.identifier.scopuseid_2-s2.0-85060918962-
dc.identifier.hkuros304172-
dc.identifier.volume11-
dc.identifier.issue2-
dc.identifier.spage129-
dc.identifier.epage129-
dc.identifier.isiWOS:000460803200039-
dc.publisher.placeSwitzerland-

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