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Article: The diagnosis and treatment of venous thromboembolism in asian patients.

TitleThe diagnosis and treatment of venous thromboembolism in asian patients.
Authors
KeywordsAsia
Epidemiology
Risk factors
Treatment
Venous thromboembolism
Issue Date2018
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.thrombosisjournal.com/home/
Citation
Thrombosis Journal, 2018, v. 16 n. 1, p. article no. 4 How to Cite?
AbstractAlthough the incidence of venous thromboembolism (VTE) in Asian populations is lower than in Western countries, the overall burden of VTE in Asia has been considerably underestimated. Factors that may explain the lower prevalence of VTE in Asian populations relative to Western populations include the limited availability of epidemiological data in Asia, ethnic differences in the genetic predisposition to VTE, underdiagnoses, low awareness toward thrombotic disease, and possibly less symptomatic VTE in Asian patients. The clinical assessment, diagnostic testing, and therapeutic considerations for VTE are, in general, the same in Asian populations as they are in Western populations. The management of VTE is based upon balancing the treatment benefits against the risk of bleeding. This is an especially important consideration for Asian populations because of increased risk of intracranial hemorrhage with vitamin K antagonists. Non-vitamin K antagonist oral anticoagulants have shown advantages over current treatment modalities with respect to bleeding outcomes in major phase 3 clinical trials, including in Asian populations. Although anticoagulant therapy has been shown to reduce the risk of postoperative VTE in Western populations, VTE prophylaxis is not administered routinely in Asian countries. Despite advances in the management of VTE, data in Asian populations on the incidence, prevalence, recurrence, risk factors, and management of bleeding complications are limited and there is need for increased awareness. To that end, this review summarizes the available data on the epidemiology, risk stratification, diagnosis, and treatment considerations in the management of VTE in Asia. © 2018 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/275125
ISSN
2019 Impact Factor: 2.295
2015 SCImago Journal Rankings: 0.982
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, KL-
dc.contributor.authorYap, ES-
dc.contributor.authorGoto, S-
dc.contributor.authorZhang, S-
dc.contributor.authorSiu, DCW-
dc.contributor.authorChiang, CE-
dc.date.accessioned2019-09-10T02:35:58Z-
dc.date.available2019-09-10T02:35:58Z-
dc.date.issued2018-
dc.identifier.citationThrombosis Journal, 2018, v. 16 n. 1, p. article no. 4-
dc.identifier.issn1477-9560-
dc.identifier.urihttp://hdl.handle.net/10722/275125-
dc.description.abstractAlthough the incidence of venous thromboembolism (VTE) in Asian populations is lower than in Western countries, the overall burden of VTE in Asia has been considerably underestimated. Factors that may explain the lower prevalence of VTE in Asian populations relative to Western populations include the limited availability of epidemiological data in Asia, ethnic differences in the genetic predisposition to VTE, underdiagnoses, low awareness toward thrombotic disease, and possibly less symptomatic VTE in Asian patients. The clinical assessment, diagnostic testing, and therapeutic considerations for VTE are, in general, the same in Asian populations as they are in Western populations. The management of VTE is based upon balancing the treatment benefits against the risk of bleeding. This is an especially important consideration for Asian populations because of increased risk of intracranial hemorrhage with vitamin K antagonists. Non-vitamin K antagonist oral anticoagulants have shown advantages over current treatment modalities with respect to bleeding outcomes in major phase 3 clinical trials, including in Asian populations. Although anticoagulant therapy has been shown to reduce the risk of postoperative VTE in Western populations, VTE prophylaxis is not administered routinely in Asian countries. Despite advances in the management of VTE, data in Asian populations on the incidence, prevalence, recurrence, risk factors, and management of bleeding complications are limited and there is need for increased awareness. To that end, this review summarizes the available data on the epidemiology, risk stratification, diagnosis, and treatment considerations in the management of VTE in Asia. © 2018 The Author(s).-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.thrombosisjournal.com/home/-
dc.relation.ispartofThrombosis Journal-
dc.rightsThrombosis Journal. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAsia-
dc.subjectEpidemiology-
dc.subjectRisk factors-
dc.subjectTreatment-
dc.subjectVenous thromboembolism-
dc.titleThe diagnosis and treatment of venous thromboembolism in asian patients.-
dc.typeArticle-
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hk-
dc.identifier.authoritySiu, DCW=rp00534-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12959-017-0155-z-
dc.identifier.pmid29375274-
dc.identifier.scopuseid_2-s2.0-85040708621-
dc.identifier.hkuros304685-
dc.identifier.volume16-
dc.identifier.issue1-
dc.identifier.spagearticle no. 4-
dc.identifier.epagearticle no. 4-
dc.identifier.isiWOS:000422889800001-
dc.publisher.placeUnited Kingdom-

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