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Article: A novel tetradentate ruthenium(II) complex containing tris(2-pyridylmethyl)amine (tpa) as an inhibitor of beta-amyloid fibrillation

TitleA novel tetradentate ruthenium(II) complex containing tris(2-pyridylmethyl)amine (tpa) as an inhibitor of beta-amyloid fibrillation
Authors
Chan, LFLu, LLam, TLYan, SCLeung, CHMa, DL
Keywords2-acetylbenzo[b]thiophen-3-olate
Alzheimer's disease
Beta-amyloid
Ruthenium(II)
Tris(2-pyridylmethyl)amine
Issue Date2015
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/car/
Citation
Current Alzheimer Research, 2015, v. 12 n. 5, p. 434-438 How to Cite?
DOI: http://dx.doi.org/10.2174/1567205012666150504150726
AbstractWe report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO4 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging. © 2015 Bentham Science Publishers.
Persistent Identifierhttp://hdl.handle.net/10722/274820
ISSN
1567-2050
2021 Impact Factor: 3.040
2020 SCImago Journal Rankings: 1.032
ISI Accession Number ID
WOS:000355189000005

 

DC FieldValueLanguage
dc.contributor.authorChan, LF-
dc.contributor.authorLu, L-
dc.contributor.authorLam, TL-
dc.contributor.authorYan, SC-
dc.contributor.authorLeung, CH-
dc.contributor.authorMa, DL-
dc.date.accessioned2019-09-10T02:29:29Z-
dc.date.available2019-09-10T02:29:29Z-
dc.date.issued2015-
dc.identifier.citationCurrent Alzheimer Research, 2015, v. 12 n. 5, p. 434-438-
dc.identifier.issn1567-2050-
dc.identifier.urihttp://hdl.handle.net/10722/274820-
dc.description.abstractWe report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO4 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging. © 2015 Bentham Science Publishers.-
dc.languageeng-
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/car/-
dc.relation.ispartofCurrent Alzheimer Research-
dc.subject2-acetylbenzo[b]thiophen-3-olate-
dc.subjectAlzheimer's disease-
dc.subjectBeta-amyloid-
dc.subjectRuthenium(II)-
dc.subjectTris(2-pyridylmethyl)amine-
dc.titleA novel tetradentate ruthenium(II) complex containing tris(2-pyridylmethyl)amine (tpa) as an inhibitor of beta-amyloid fibrillation-
dc.typeArticle-
dc.identifier.emailLam, TL: joeltl@hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/1567205012666150504150726-
dc.identifier.pmid25938869-
dc.identifier.scopuseid_2-s2.0-84930911730-
dc.identifier.hkuros302623-
dc.identifier.volume12-
dc.identifier.issue5-
dc.identifier.spage434-
dc.identifier.epage438-
dc.identifier.isiWOS:000355189000005-
dc.publisher.placeNetherlands-
dc.identifier.issnl1567-2050-

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