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Article: Strategies to Enhance the Photosensitization: Polymerization and the Donor-Acceptor Even-Odd Effect

TitleStrategies to Enhance the Photosensitization: Polymerization and the Donor-Acceptor Even-Odd Effect
Authors
Issue Date2018
Citation
Angewandte Chemie-International Edition, 2018, v. 57 n. 46, p. 15189-15193 How to Cite?
AbstractA particular challenge in the design of organic photosensitizers (PSs) with donor-acceptor (D-A) structures is that it is based on trial and error rather than specific rules. Now these challenges are addressed by proposing two efficient strategies to enhance the photosensitization efficiency: polymerization-facilitated photosensitization and the D-A even-odd effect. Conjugated polymers have been found to exhibit a higher O-1(2) generation efficiency than their small molecular counterparts. Furthermore, PSs with A-D-A structures show enhanced photosensitization efficiency over those with D-A-D structures. Theoretical calculations suggest an enhanced inter-system crossing (ISC) efficiency by these strategies. Both in vitro and in vivo experiments demonstrate that the resulting materials can be used as photosensitizers in image-guided photodynamic anticancer therapy. These guidelines are applicable to other polymers and small molecules to lead to the development of new PSs.
Persistent Identifierhttp://hdl.handle.net/10722/274403

 

DC FieldValueLanguage
dc.contributor.authorLiu, SJ-
dc.contributor.authorZhang, HK-
dc.contributor.authorLi, YY-
dc.contributor.authorLiu, JK-
dc.contributor.authorDu, L-
dc.contributor.authorChen, M-
dc.contributor.authorKwok, RTK-
dc.contributor.authorLam, JWY-
dc.contributor.authorPhillips, DL-
dc.contributor.authorTang, BZ-
dc.date.accessioned2019-08-18T15:01:03Z-
dc.date.available2019-08-18T15:01:03Z-
dc.date.issued2018-
dc.identifier.citationAngewandte Chemie-International Edition, 2018, v. 57 n. 46, p. 15189-15193-
dc.identifier.urihttp://hdl.handle.net/10722/274403-
dc.description.abstractA particular challenge in the design of organic photosensitizers (PSs) with donor-acceptor (D-A) structures is that it is based on trial and error rather than specific rules. Now these challenges are addressed by proposing two efficient strategies to enhance the photosensitization efficiency: polymerization-facilitated photosensitization and the D-A even-odd effect. Conjugated polymers have been found to exhibit a higher O-1(2) generation efficiency than their small molecular counterparts. Furthermore, PSs with A-D-A structures show enhanced photosensitization efficiency over those with D-A-D structures. Theoretical calculations suggest an enhanced inter-system crossing (ISC) efficiency by these strategies. Both in vitro and in vivo experiments demonstrate that the resulting materials can be used as photosensitizers in image-guided photodynamic anticancer therapy. These guidelines are applicable to other polymers and small molecules to lead to the development of new PSs.-
dc.languageeng-
dc.relation.ispartofAngewandte Chemie-International Edition-
dc.titleStrategies to Enhance the Photosensitization: Polymerization and the Donor-Acceptor Even-Odd Effect-
dc.typeArticle-
dc.identifier.emailDu, L: ailleen@hku.hk-
dc.identifier.emailPhillips, DL: phillips@hku.hk-
dc.identifier.authorityPhillips, DL=rp00770-
dc.identifier.doi10.1002/anie.201810326-
dc.identifier.hkuros300965-
dc.identifier.volume57-
dc.identifier.issue46-
dc.identifier.spage15189-
dc.identifier.epage15193-

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