File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Comparing antral follicle count and serum anti‐Mullerian hormone level for determination of gonadotrophin dosing in in‐vitro fertilisation: a randomized trial

TitleComparing antral follicle count and serum anti‐Mullerian hormone level for determination of gonadotrophin dosing in in‐vitro fertilisation: a randomized trial
Authors
KeywordsAntral follicle count
anti‐Mullerian hormone
gonadotrophin dosing
in vitro fertilsation
ovarian response
Issue Date2019
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/
Citation
Ultrasound in Obstetrics and Gynecology, 2019, Epub How to Cite?
AbstractObjectives: To compare the proportion of women having a desired ovarian response following ovarian stimulation with gonadotrophin dosing determined based on AFC versus serum AMH level in women undergoing IVF using the GnRH antagonist protocol. Methods: This was a randomised double‐blinded trial carried out in a university‐affiliated assisted reproduction unit. A total of 200 women undergoing the first IVF cycle between April 2016 and February 2018 were randomised to algorithms for gonadotrophin dosing based on either AFC or AMH in the pre‐treatment cycle. They underwent IVF as per standard protocol. The proportion of subjects achieving desired ovarian response, defined as having 6 to 14 oocytes retrieved, was compared between arms. Results: There was no significant difference in the proportion achieving desired ovarian response between the AFC (56.3%) and AMH (51.6%) groups (p=0.523). The median number of oocytes retrieved were 9 vs 7 (p=0.064), and the median follicular output rate (FORT) was 0.56 vs 0.55 (p=0.759) in the AFC and AMH groups respectively. The same conclusion applied to subgroup analyses on subjects with AFC<=5 and AFC>5 at commencement of ovarian stimulation (P>0.05 for all comparisons). There was moderate concordance between AFC and AMH measured in the pre‐treatment cycle and the stimulation cycle (ĸ = 0.460 and 0.573 respectively). Conclusions: Gonadotrophin dosing algorithms based on either AFC or serum AMH result in no significant difference in the proportion achieving desired ovarian response.
Persistent Identifierhttp://hdl.handle.net/10722/274100
ISSN
2017 Impact Factor: 5.654
2015 SCImago Journal Rankings: 1.766

 

DC FieldValueLanguage
dc.contributor.authorLi, HWR-
dc.contributor.authorKo, KYJ-
dc.contributor.authorLee, VCY-
dc.contributor.authorYung, SSF-
dc.contributor.authorLau, EYL-
dc.contributor.authorYeung, WSB-
dc.contributor.authorHo, PC-
dc.contributor.authorNg, EHY-
dc.date.accessioned2019-08-18T14:55:04Z-
dc.date.available2019-08-18T14:55:04Z-
dc.date.issued2019-
dc.identifier.citationUltrasound in Obstetrics and Gynecology, 2019, Epub-
dc.identifier.issn0960-7692-
dc.identifier.urihttp://hdl.handle.net/10722/274100-
dc.description.abstractObjectives: To compare the proportion of women having a desired ovarian response following ovarian stimulation with gonadotrophin dosing determined based on AFC versus serum AMH level in women undergoing IVF using the GnRH antagonist protocol. Methods: This was a randomised double‐blinded trial carried out in a university‐affiliated assisted reproduction unit. A total of 200 women undergoing the first IVF cycle between April 2016 and February 2018 were randomised to algorithms for gonadotrophin dosing based on either AFC or AMH in the pre‐treatment cycle. They underwent IVF as per standard protocol. The proportion of subjects achieving desired ovarian response, defined as having 6 to 14 oocytes retrieved, was compared between arms. Results: There was no significant difference in the proportion achieving desired ovarian response between the AFC (56.3%) and AMH (51.6%) groups (p=0.523). The median number of oocytes retrieved were 9 vs 7 (p=0.064), and the median follicular output rate (FORT) was 0.56 vs 0.55 (p=0.759) in the AFC and AMH groups respectively. The same conclusion applied to subgroup analyses on subjects with AFC<=5 and AFC>5 at commencement of ovarian stimulation (P>0.05 for all comparisons). There was moderate concordance between AFC and AMH measured in the pre‐treatment cycle and the stimulation cycle (ĸ = 0.460 and 0.573 respectively). Conclusions: Gonadotrophin dosing algorithms based on either AFC or serum AMH result in no significant difference in the proportion achieving desired ovarian response.-
dc.languageeng-
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/-
dc.relation.ispartofUltrasound in Obstetrics and Gynecology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectAntral follicle count-
dc.subjectanti‐Mullerian hormone-
dc.subjectgonadotrophin dosing-
dc.subjectin vitro fertilsation-
dc.subjectovarian response-
dc.titleComparing antral follicle count and serum anti‐Mullerian hormone level for determination of gonadotrophin dosing in in‐vitro fertilisation: a randomized trial-
dc.typeArticle-
dc.identifier.emailLi, HWR: raymondli@hku.hk-
dc.identifier.emailKo, KYJ: jenko@HKUCC-COM.hku.hk-
dc.identifier.emailLee, VCY: v200lee@HKUCC-COM.hku.hk-
dc.identifier.emailYung, SSF: ssfyung@hku.hk-
dc.identifier.emailLau, EYL: eyllau@HKUCC-COM.hku.hk-
dc.identifier.emailYeung, WSB: wsbyeung@hku.hk-
dc.identifier.emailHo, PC: pcho@hku.hk-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.authorityLi, HWR=rp01649-
dc.identifier.authorityYung, SSF=rp00287-
dc.identifier.authorityYeung, WSB=rp00331-
dc.identifier.authorityHo, PC=rp00325-
dc.identifier.authorityNg, EHY=rp00426-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/uog.20402-
dc.identifier.pmid31325336-
dc.identifier.hkuros302142-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats