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Article: Development of the Asia Pacific Lupus Collaboration cohort

TitleDevelopment of the Asia Pacific Lupus Collaboration cohort
Authors
KeywordsAsia Pacific region
lupus low disease activity state
systemic lupus erythematous
Issue Date2019
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwell-synergy.com/loi/ijrd
Citation
International Journal of Rheumatic Diseases, 2019, v. 22 n. 3, p. 425-433 How to Cite?
AbstractAim The aim of this manuscript is to describe the development of the Asia Pacific Lupus Collaboration (APLC) cohort. Method The APLC cohort is an ongoing, prospective longitudinal cohort. Adult patients who meet either the American College of Rheumatology (ACR) Modified Classification Criteria for systemic lupus erythematosus (SLE), or the Systemic Lupus International Collaborating Clinics (SLICC) Classification Criteria, and provide informed consent are recruited into the cohort. Patients are routinely followed up at 3‐ to 6‐monthly intervals. Information on demographics, clinical manifestations, treatment, pathology results, outcomes, and patient‐reported quality of life (Short‐form 36 version 2) are collected using a standardized case report form. Each site is responsible for obtaining local ethics and governance approval, patient recruitment, data collection, and data transfer into a centralized APLC database. Results The latest APLC cohort comprises 2160 patients with >12 000 visits from Australia, China, Hong Kong, Indonesia, Japan, Malaysia, Philippines, Singapore, Taiwan and Thailand. The APLC has proposed the Lupus Low Disease Activity State (LLDAS) as a treat‐to‐target (T2T) endpoint, and reported several retrospective and cross‐sectional analyses consistent with the validity of LLDAS. Longitudinal validation of LLDAS as a T2T endpoint is currently underway. Conclusion The APLC cohort is one of the largest contemporary SLE patient cohorts in the world. It is the only cohort with substantial representation of Asian patients. This cohort represents a unique resource for future clinical research including evaluation of other endpoints and quality of care.
Persistent Identifierhttp://hdl.handle.net/10722/273939
ISSN
2017 Impact Factor: 2.423
2015 SCImago Journal Rankings: 0.536
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKandane‐Rathnayake, R-
dc.contributor.authorGolder, V-
dc.contributor.authorLouthrenoo, W-
dc.contributor.authorLuo, SF-
dc.contributor.authorJand Wu, YJ-
dc.contributor.authorLi, Z-
dc.contributor.authorAn, Y-
dc.contributor.authorLateef, A-
dc.contributor.authorSockalingam, S-
dc.contributor.authorNavarra, SV-
dc.contributor.authorZamora, L-
dc.contributor.authorHamijoyo, L-
dc.contributor.authorKatsumata, Y-
dc.contributor.authorHarigai, M-
dc.contributor.authorChan, M-
dc.contributor.authorO’Neill, S-
dc.contributor.authorGoldblatt, F-
dc.contributor.authorHao, Y-
dc.contributor.authorZhang, Z-
dc.contributor.authorAl‐Saleh, J-
dc.contributor.authorKhamashta, M-
dc.contributor.authorTakeuchi, T-
dc.contributor.authorTanaka, Y-
dc.contributor.authorBae, SC-
dc.contributor.authorLau, WCS-
dc.contributor.authorHoi, A-
dc.contributor.authorNikpour, M-
dc.contributor.authorMorand, EF-
dc.date.accessioned2019-08-18T14:51:46Z-
dc.date.available2019-08-18T14:51:46Z-
dc.date.issued2019-
dc.identifier.citationInternational Journal of Rheumatic Diseases, 2019, v. 22 n. 3, p. 425-433-
dc.identifier.issn1756-1841-
dc.identifier.urihttp://hdl.handle.net/10722/273939-
dc.description.abstractAim The aim of this manuscript is to describe the development of the Asia Pacific Lupus Collaboration (APLC) cohort. Method The APLC cohort is an ongoing, prospective longitudinal cohort. Adult patients who meet either the American College of Rheumatology (ACR) Modified Classification Criteria for systemic lupus erythematosus (SLE), or the Systemic Lupus International Collaborating Clinics (SLICC) Classification Criteria, and provide informed consent are recruited into the cohort. Patients are routinely followed up at 3‐ to 6‐monthly intervals. Information on demographics, clinical manifestations, treatment, pathology results, outcomes, and patient‐reported quality of life (Short‐form 36 version 2) are collected using a standardized case report form. Each site is responsible for obtaining local ethics and governance approval, patient recruitment, data collection, and data transfer into a centralized APLC database. Results The latest APLC cohort comprises 2160 patients with >12 000 visits from Australia, China, Hong Kong, Indonesia, Japan, Malaysia, Philippines, Singapore, Taiwan and Thailand. The APLC has proposed the Lupus Low Disease Activity State (LLDAS) as a treat‐to‐target (T2T) endpoint, and reported several retrospective and cross‐sectional analyses consistent with the validity of LLDAS. Longitudinal validation of LLDAS as a T2T endpoint is currently underway. Conclusion The APLC cohort is one of the largest contemporary SLE patient cohorts in the world. It is the only cohort with substantial representation of Asian patients. This cohort represents a unique resource for future clinical research including evaluation of other endpoints and quality of care.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwell-synergy.com/loi/ijrd-
dc.relation.ispartofInternational Journal of Rheumatic Diseases-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectAsia Pacific region-
dc.subjectlupus low disease activity state-
dc.subjectsystemic lupus erythematous-
dc.titleDevelopment of the Asia Pacific Lupus Collaboration cohort-
dc.typeArticle-
dc.identifier.emailLau, WCS: cslau@hku.hk-
dc.identifier.authorityLau, WCS=rp01348-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/1756-185X.13431-
dc.identifier.pmid30398013-
dc.identifier.scopuseid_2-s2.0-85055941968-
dc.identifier.hkuros301856-
dc.identifier.volume22-
dc.identifier.issue3-
dc.identifier.spage425-
dc.identifier.epage433-
dc.identifier.isiWOS:000461908400010-
dc.publisher.placeAustralia-

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