File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Assessment of human-to-human transmissibility of avian influenza A(H7N9) virus across 5 waves by analyzing clusters of case patients in Mainland China, 2013-2017

TitleAssessment of human-to-human transmissibility of avian influenza A(H7N9) virus across 5 waves by analyzing clusters of case patients in Mainland China, 2013-2017
Authors
KeywordsHuman-to-human transmissibility
Genetic susceptibility
Cluster
Influenza A(H7N9)
Issue Date2019
Citation
Clinical Infectious Diseases, 2019, v. 68, n. 4, p. 623-631 How to Cite?
Abstract© The Author(s) 2018. Background. The 2016-17 epidemic of human infections with avian influenza A(H7N9) virus was alarming, due to the surge in reported cases across a wide geographic area and the emergence of highly-pathogenic A(H7N9) viruses. Our study aimed to assess whether the human-to-human transmission risk of A(H7N9) virus has changed across the 5 waves since 2013. Methods. Data on human cases and clusters of A(H7N9) virus infection were collected from the World Health Organization, open access national and provincial reports, informal online sources, and published literature. We compared the epidemiological characteristics of sporadic and cluster cases, estimated the relative risk (RR) of infection in blood relatives and non-blood relatives, and estimated the bounds on the effective reproductive number (Re) across waves from 2013 through September 2017. Results. We identified 40 human clusters of A(H7N9) virus infection, with a median cluster size of 2 (range 2-3). The overall RR of infection in blood relatives versus non-blood relatives was 1.65 (95% confidence interval [CI]: 0.88, 3.09), and was not significantly different across waves (X2 = 2.66, P = .617). The upper limit of Re for A(H7N9) virus was 0.12 (95% CI: 0.10, 0.14) and was not significantly different across waves (X2 = 1.52, P = .822). Conclusions. The small cluster size and low Re suggest that human-to-human transmissibility of A(H7N9) virus has not changed over time and remains limited to date. Continuous assessment of A(H7N9) virus infections and human case clusters is of crucial importance for public health.
Persistent Identifierhttp://hdl.handle.net/10722/273684
ISSN
2017 Impact Factor: 9.117
2015 SCImago Journal Rankings: 4.742

 

DC FieldValueLanguage
dc.contributor.authorWang, Xiling-
dc.contributor.authorWu, Peng-
dc.contributor.authorPei, Yao-
dc.contributor.authorTsang, Tim K.-
dc.contributor.authorGu, Dantong-
dc.contributor.authorWang, Wei-
dc.contributor.authorZhang, Juanjuan-
dc.contributor.authorHorby, Peter W.-
dc.contributor.authorUyeki, Timothy M.-
dc.contributor.authorCowling, Benjamin J.-
dc.contributor.authorYu, Hongjie-
dc.date.accessioned2019-08-12T09:56:21Z-
dc.date.available2019-08-12T09:56:21Z-
dc.date.issued2019-
dc.identifier.citationClinical Infectious Diseases, 2019, v. 68, n. 4, p. 623-631-
dc.identifier.issn1058-4838-
dc.identifier.urihttp://hdl.handle.net/10722/273684-
dc.description.abstract© The Author(s) 2018. Background. The 2016-17 epidemic of human infections with avian influenza A(H7N9) virus was alarming, due to the surge in reported cases across a wide geographic area and the emergence of highly-pathogenic A(H7N9) viruses. Our study aimed to assess whether the human-to-human transmission risk of A(H7N9) virus has changed across the 5 waves since 2013. Methods. Data on human cases and clusters of A(H7N9) virus infection were collected from the World Health Organization, open access national and provincial reports, informal online sources, and published literature. We compared the epidemiological characteristics of sporadic and cluster cases, estimated the relative risk (RR) of infection in blood relatives and non-blood relatives, and estimated the bounds on the effective reproductive number (Re) across waves from 2013 through September 2017. Results. We identified 40 human clusters of A(H7N9) virus infection, with a median cluster size of 2 (range 2-3). The overall RR of infection in blood relatives versus non-blood relatives was 1.65 (95% confidence interval [CI]: 0.88, 3.09), and was not significantly different across waves (X2 = 2.66, P = .617). The upper limit of Re for A(H7N9) virus was 0.12 (95% CI: 0.10, 0.14) and was not significantly different across waves (X2 = 1.52, P = .822). Conclusions. The small cluster size and low Re suggest that human-to-human transmissibility of A(H7N9) virus has not changed over time and remains limited to date. Continuous assessment of A(H7N9) virus infections and human case clusters is of crucial importance for public health.-
dc.languageeng-
dc.relation.ispartofClinical Infectious Diseases-
dc.subjectHuman-to-human transmissibility-
dc.subjectGenetic susceptibility-
dc.subjectCluster-
dc.subjectInfluenza A(H7N9)-
dc.titleAssessment of human-to-human transmissibility of avian influenza A(H7N9) virus across 5 waves by analyzing clusters of case patients in Mainland China, 2013-2017-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1093/cid/ciy541-
dc.identifier.pmid29961834-
dc.identifier.scopuseid_2-s2.0-85060968265-
dc.identifier.volume68-
dc.identifier.issue4-
dc.identifier.spage623-
dc.identifier.epage631-
dc.identifier.eissn1537-6591-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats