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Article: Active Acupoints Differ from Inactive Acupoints in Modulating Key Plasmatic Metabolites of Hypertension: A Targeted Metabolomics Study

TitleActive Acupoints Differ from Inactive Acupoints in Modulating Key Plasmatic Metabolites of Hypertension: A Targeted Metabolomics Study
Authors
KeywordsAcupuncture
Electroacupuncture
EA stimulation
Issue Date2018
PublisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2018, v. 8, p. article no. 17824 How to Cite?
AbstractThe effect of active acupoints versus inactive acupoints in treating hypertension is not well documented. Metabolic phenotypes, depicted by metabolomics analysis, reflect the influence of external exposures, nutrition, and lifestyle on the integrated system of the human body. Therefore, we utilized high-performance liquid chromatography tandem mass spectrometry to compare the targeted metabolic phenotype changes induced by two different acupoint treatments. The clinical outcomes show that active acupoint treatment significantly lowers 24-hour systolic blood pressure but not diastolic blood pressure, as compared with inactive acupoint treatment. Furthermore, distinctive changes are observed between the metabolomics data of the two groups. Multivariate analysis shows that only in the active acupoint treatment group can the follow-up plasma be clearly separated from the baseline plasma. Moreover, the follow-up plasma of these two groups can be clearly separated, indicating two different post-treatment metabolic phenotypes. Three metabolites, sucrose, cellobiose, and hypoxanthine, are shown to be the most important features of active acupoint treatment. This study demonstrates that metabolomic analysis is a potential tool that can be used to efficiently differentiate the effect of active acupoints from inactive acupoints in treating hypertension. Possible mechanisms are the alternation of hypothalamic microinflammation and the restoration of host-gut microbiota interactions induced by acupuncture.
Persistent Identifierhttp://hdl.handle.net/10722/273195
ISSN
2017 Impact Factor: 4.122
2015 SCImago Journal Rankings: 2.073
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorYang, C-
dc.contributor.authorYu, Z-
dc.contributor.authorChen, X-
dc.contributor.authorGuo, Z-
dc.contributor.authorDeng, S-
dc.contributor.authorChen, L-
dc.contributor.authorWu, Q-
dc.contributor.authorLiang, F-
dc.date.accessioned2019-08-06T09:24:19Z-
dc.date.available2019-08-06T09:24:19Z-
dc.date.issued2018-
dc.identifier.citationScientific Reports, 2018, v. 8, p. article no. 17824-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/273195-
dc.description.abstractThe effect of active acupoints versus inactive acupoints in treating hypertension is not well documented. Metabolic phenotypes, depicted by metabolomics analysis, reflect the influence of external exposures, nutrition, and lifestyle on the integrated system of the human body. Therefore, we utilized high-performance liquid chromatography tandem mass spectrometry to compare the targeted metabolic phenotype changes induced by two different acupoint treatments. The clinical outcomes show that active acupoint treatment significantly lowers 24-hour systolic blood pressure but not diastolic blood pressure, as compared with inactive acupoint treatment. Furthermore, distinctive changes are observed between the metabolomics data of the two groups. Multivariate analysis shows that only in the active acupoint treatment group can the follow-up plasma be clearly separated from the baseline plasma. Moreover, the follow-up plasma of these two groups can be clearly separated, indicating two different post-treatment metabolic phenotypes. Three metabolites, sucrose, cellobiose, and hypoxanthine, are shown to be the most important features of active acupoint treatment. This study demonstrates that metabolomic analysis is a potential tool that can be used to efficiently differentiate the effect of active acupoints from inactive acupoints in treating hypertension. Possible mechanisms are the alternation of hypothalamic microinflammation and the restoration of host-gut microbiota interactions induced by acupuncture.-
dc.languageeng-
dc.publisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAcupuncture-
dc.subjectElectroacupuncture-
dc.subjectEA stimulation-
dc.titleActive Acupoints Differ from Inactive Acupoints in Modulating Key Plasmatic Metabolites of Hypertension: A Targeted Metabolomics Study-
dc.typeArticle-
dc.identifier.emailYang, C: mxyang@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-018-36199-1-
dc.identifier.pmid30546033-
dc.identifier.pmcidPMC6292875-
dc.identifier.scopuseid_2-s2.0-85058595279-
dc.identifier.hkuros299830-
dc.identifier.volume8-
dc.identifier.spagearticle no. 17824-
dc.identifier.epagearticle no. 17824-
dc.publisher.placeUnited Kingdom-

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