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Article: Linked-color imaging versus narrow-band imaging for colorectal polyp detection: a prospective randomized tandem colonoscopy study

TitleLinked-color imaging versus narrow-band imaging for colorectal polyp detection: a prospective randomized tandem colonoscopy study
Authors
Issue Date2019
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/gie
Citation
Gastrointestinal Endoscopy, 2019 How to Cite?
AbstractBackground and Aims: Linked-color imaging (LCI) is a newly available image enhanced endoscopy (IEE) system, which emphasizes the red mucosal color. No study has yet compared LCI with other available IEE systems. Aim: To compare the polyp detection rates of LCI with narrow band imaging (NBI). Methods: This is a prospective randomized tandem colonoscopy study. Eligible patients who underwent colonoscopy for symptoms or screening/surveillance were randomized in a 1:1 ratio to receive tandem colonoscopy with both colonoscope withdrawals using LCI or NBI. The primary outcome was polyp detection rate. Results: Two hundred seventy-two patients were randomized (mean age 62 years; 48.2% male; colonoscopy for symptoms: 72.8%) with 136 in each arm. During first colonoscopy, the NBI group had significantly higher polyp detection rate (71.3% vs 55.9%; P = 0.008), serrated lesion detection rate (34.6% vs 22.1%; P = 0.02), and mean number of polyps detected (2.04 vs 1.35; P = 0.02) than the LCI group. There was also a trend of higher adenoma detection rate in the NBI group (51.5% vs 39.7% in LCI; P = 0.05). Multivariable analysis confirmed that use of NBI (adjusted OR, 1.99; 95% CI, 1.09-3.68) and withdrawal time >8 minutes (aOR, 5.11; 95% CI, 2.79-9.67) were associated with polyp detection. Overall, 20.5% of polyps and 18.1% of adenoma were missed by first colonoscopy, but there was no significant difference in the miss rates between the 2 groups. Conclusion: NBI was significantly better than LCI for colorectal polyp detection. However, both LCI and NBI missed 20.5% of polyps.
Persistent Identifierhttp://hdl.handle.net/10722/272936
ISSN
2017 Impact Factor: 7.204
2015 SCImago Journal Rankings: 2.390

 

DC FieldValueLanguage
dc.contributor.authorLeung, WK-
dc.contributor.authorGuo, C-
dc.contributor.authorKo, MKL-
dc.contributor.authorTo, EWP-
dc.contributor.authorMak, LY-
dc.contributor.authorTong, TSM-
dc.contributor.authorChen, L-
dc.contributor.authorBut, DYK-
dc.contributor.authorWong, SY-
dc.contributor.authorLiu, KSH-
dc.contributor.authorTsui, V-
dc.contributor.authorLam, FYF-
dc.contributor.authorLui, TKL-
dc.contributor.authorCheung, KSM-
dc.contributor.authorLo, SH-
dc.contributor.authorHung, FNI-
dc.date.accessioned2019-08-06T09:19:24Z-
dc.date.available2019-08-06T09:19:24Z-
dc.date.issued2019-
dc.identifier.citationGastrointestinal Endoscopy, 2019-
dc.identifier.issn0016-5107-
dc.identifier.urihttp://hdl.handle.net/10722/272936-
dc.description.abstractBackground and Aims: Linked-color imaging (LCI) is a newly available image enhanced endoscopy (IEE) system, which emphasizes the red mucosal color. No study has yet compared LCI with other available IEE systems. Aim: To compare the polyp detection rates of LCI with narrow band imaging (NBI). Methods: This is a prospective randomized tandem colonoscopy study. Eligible patients who underwent colonoscopy for symptoms or screening/surveillance were randomized in a 1:1 ratio to receive tandem colonoscopy with both colonoscope withdrawals using LCI or NBI. The primary outcome was polyp detection rate. Results: Two hundred seventy-two patients were randomized (mean age 62 years; 48.2% male; colonoscopy for symptoms: 72.8%) with 136 in each arm. During first colonoscopy, the NBI group had significantly higher polyp detection rate (71.3% vs 55.9%; P = 0.008), serrated lesion detection rate (34.6% vs 22.1%; P = 0.02), and mean number of polyps detected (2.04 vs 1.35; P = 0.02) than the LCI group. There was also a trend of higher adenoma detection rate in the NBI group (51.5% vs 39.7% in LCI; P = 0.05). Multivariable analysis confirmed that use of NBI (adjusted OR, 1.99; 95% CI, 1.09-3.68) and withdrawal time >8 minutes (aOR, 5.11; 95% CI, 2.79-9.67) were associated with polyp detection. Overall, 20.5% of polyps and 18.1% of adenoma were missed by first colonoscopy, but there was no significant difference in the miss rates between the 2 groups. Conclusion: NBI was significantly better than LCI for colorectal polyp detection. However, both LCI and NBI missed 20.5% of polyps.-
dc.languageeng-
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/gie-
dc.relation.ispartofGastrointestinal Endoscopy-
dc.titleLinked-color imaging versus narrow-band imaging for colorectal polyp detection: a prospective randomized tandem colonoscopy study-
dc.typeArticle-
dc.identifier.emailLeung, WK: waikleung@hku.hk-
dc.identifier.emailTong, TSM: tongsma@hkucc.hku.hk-
dc.identifier.emailChen, L: equalclj@hku.hk-
dc.identifier.emailLam, FYF: fyflam@hku.hk-
dc.identifier.emailCheung, KSM: cks634@hku.hk-
dc.identifier.emailHung, FNI: ivanhung@hkucc.hku.hk-
dc.identifier.authorityLeung, WK=rp01479-
dc.identifier.authorityLam, FYF=rp02564-
dc.identifier.authorityCheung, KSM=rp02532-
dc.identifier.authorityHung, FNI=rp00508-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.gie.2019.06.031-
dc.identifier.pmid31276672-
dc.identifier.hkuros300748-
dc.publisher.placeUnited States-

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