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Article: Removal of cytostatic drugs from wastewater by an anaerobic osmotic membrane bioreactor

TitleRemoval of cytostatic drugs from wastewater by an anaerobic osmotic membrane bioreactor
Authors
KeywordsBiodegradation
Chemotherapy
Health risks
Membranes
Osmosis
Issue Date2018
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cej
Citation
Chemical Engineering Journal, 2018, v. 339, p. 153-161 How to Cite?
AbstractCytostatic drugs, mainly used as chemotherapy compounds, can pose serious threats to aqueous ecosystem and human health once released into the natural environment. We investigated the use of an anaerobic osmotic membrane bioreactor (AnOMBR) for removing cytostatic drugs from wastewater. The AnOMBR utilizes a dense forward osmosis (FO) membrane in an anaerobic digester with prolonged sludge retention time (60 days). The high rejection of the FO membrane combined with the extended organic retention time in the reactor ensured high removal rates (more than 95.6%) for all the eight cytostatic drugs investigated. With regard to their removal routes in the AnOMBR, the eight cytostatic drugs can be divided into several groups. Doxorubicin, Epirubicin and Tamoxifen were nearly completely removed through the adsorption of anaerobic sludge, while Methotrexate and Cyclophosphamide were mainly removed by biodegradation and FO rejection, respectively. In addition, Mitotane, Azathioprine and Flutamide were removed by both biodegradation and adsorption. This work provides critical insights into the removal mechanisms of high-retention AnOMBRs.
Persistent Identifierhttp://hdl.handle.net/10722/272849
ISSN
2017 Impact Factor: 6.735
2015 SCImago Journal Rankings: 1.743

 

DC FieldValueLanguage
dc.contributor.authorWang, X-
dc.contributor.authorZhang, J-
dc.contributor.authorChang, VWC-
dc.contributor.authorShe, Q-
dc.contributor.authorTang, CY-
dc.date.accessioned2019-08-06T09:17:44Z-
dc.date.available2019-08-06T09:17:44Z-
dc.date.issued2018-
dc.identifier.citationChemical Engineering Journal, 2018, v. 339, p. 153-161-
dc.identifier.issn1385-8947-
dc.identifier.urihttp://hdl.handle.net/10722/272849-
dc.description.abstractCytostatic drugs, mainly used as chemotherapy compounds, can pose serious threats to aqueous ecosystem and human health once released into the natural environment. We investigated the use of an anaerobic osmotic membrane bioreactor (AnOMBR) for removing cytostatic drugs from wastewater. The AnOMBR utilizes a dense forward osmosis (FO) membrane in an anaerobic digester with prolonged sludge retention time (60 days). The high rejection of the FO membrane combined with the extended organic retention time in the reactor ensured high removal rates (more than 95.6%) for all the eight cytostatic drugs investigated. With regard to their removal routes in the AnOMBR, the eight cytostatic drugs can be divided into several groups. Doxorubicin, Epirubicin and Tamoxifen were nearly completely removed through the adsorption of anaerobic sludge, while Methotrexate and Cyclophosphamide were mainly removed by biodegradation and FO rejection, respectively. In addition, Mitotane, Azathioprine and Flutamide were removed by both biodegradation and adsorption. This work provides critical insights into the removal mechanisms of high-retention AnOMBRs.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cej-
dc.relation.ispartofChemical Engineering Journal-
dc.subjectBiodegradation-
dc.subjectChemotherapy-
dc.subjectHealth risks-
dc.subjectMembranes-
dc.subjectOsmosis-
dc.titleRemoval of cytostatic drugs from wastewater by an anaerobic osmotic membrane bioreactor-
dc.typeArticle-
dc.identifier.emailTang, CY: tangc@hku.hk-
dc.identifier.authorityTang, CY=rp01765-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cej.2018.01.125-
dc.identifier.scopuseid_2-s2.0-85046378744-
dc.identifier.hkuros299785-
dc.identifier.volume339-
dc.identifier.spage153-
dc.identifier.epage161-
dc.publisher.placeNetherlands-

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