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Conference Paper: D.01 Earlier treatment with the Ketogenic Diet improves seizure outcome in early-onset drug-resistant epilepsy

TitleD.01 Earlier treatment with the Ketogenic Diet improves seizure outcome in early-onset drug-resistant epilepsy
Authors
Issue Date2016
PublisherCambridge University Press. The Journal's web site is located at https://www.cambridge.org/core/journals/canadian-journal-of-neurological-sciences
Citation
51st Annual Congress of the Canadian Neurological Sciences Federation, Quebec City, Canada, 21-24 June 2016. In Canadian Journal of Neurological Sciences, 2016, v. 43 n. S2, p. S13 How to Cite?
AbstractBackground: The ketogenic diet (KD) is used to treat severe childhood-onset epileptic encephalopathies, such as Infantile Spasms (IS). Unfortunately, limited resources for KD initiation result in treatment delays. We ask if earlier KD treatment of early-onset drug-resistant epilepsy results in better seizure outcomes. Methods: Children who started KD before age 4 years between 2000-present at SickKids Hospital were identified. Six-month seizure outcome was calculated as percent of pre-diet baseline seizure frequency (BSF). Results: 67 children were identified. 30 (44.8%) started KD <2 years old, 37 (55.2%) started KD 2-4 years old. Among <2 years old group, 83.3% achieved 50% reduction in BSF and 36.7% achieved 90% reduction. Among 2-4 year old group, 62.2% achieved 50% reduction in BSF and 24.3% achieved 90% reduction. 38 children had a history of IS; 17 with IS at diet initiation and 21 with past history of IS. 41.2% of the spasms cohort achieved 90% reduction in BSF, compared to 23.8% of the post-spasms cohort. Conclusions: KD was more effective when started before age 2 years than 2-4 years, and more effective in children with IS than in children with past history of IS. A rapid protocol for KD initiation in young infants and children may improve long-term outcomes
DescriptionABSTRACT
Persistent Identifierhttp://hdl.handle.net/10722/272828
ISSN
2017 Impact Factor: 2.006
2015 SCImago Journal Rankings: 0.477

 

DC FieldValueLanguage
dc.contributor.authorIrwin, M-
dc.contributor.authorAimola, S-
dc.contributor.authorLowe, H-
dc.contributor.authorLiu, Y-
dc.contributor.authorZak, M-
dc.contributor.authorChan, V-
dc.contributor.authorKobayashi, J-
dc.contributor.authorDonner, EJ-
dc.date.accessioned2019-08-06T09:17:19Z-
dc.date.available2019-08-06T09:17:19Z-
dc.date.issued2016-
dc.identifier.citation51st Annual Congress of the Canadian Neurological Sciences Federation, Quebec City, Canada, 21-24 June 2016. In Canadian Journal of Neurological Sciences, 2016, v. 43 n. S2, p. S13-
dc.identifier.issn0317-1671-
dc.identifier.urihttp://hdl.handle.net/10722/272828-
dc.descriptionABSTRACT-
dc.description.abstractBackground: The ketogenic diet (KD) is used to treat severe childhood-onset epileptic encephalopathies, such as Infantile Spasms (IS). Unfortunately, limited resources for KD initiation result in treatment delays. We ask if earlier KD treatment of early-onset drug-resistant epilepsy results in better seizure outcomes. Methods: Children who started KD before age 4 years between 2000-present at SickKids Hospital were identified. Six-month seizure outcome was calculated as percent of pre-diet baseline seizure frequency (BSF). Results: 67 children were identified. 30 (44.8%) started KD <2 years old, 37 (55.2%) started KD 2-4 years old. Among <2 years old group, 83.3% achieved 50% reduction in BSF and 36.7% achieved 90% reduction. Among 2-4 year old group, 62.2% achieved 50% reduction in BSF and 24.3% achieved 90% reduction. 38 children had a history of IS; 17 with IS at diet initiation and 21 with past history of IS. 41.2% of the spasms cohort achieved 90% reduction in BSF, compared to 23.8% of the post-spasms cohort. Conclusions: KD was more effective when started before age 2 years than 2-4 years, and more effective in children with IS than in children with past history of IS. A rapid protocol for KD initiation in young infants and children may improve long-term outcomes-
dc.languageeng-
dc.publisherCambridge University Press. The Journal's web site is located at https://www.cambridge.org/core/journals/canadian-journal-of-neurological-sciences-
dc.relation.ispartofCanadian Journal of Neurological Sciences-
dc.rightsCanadian Journal of Neurological Sciences. Copyright © Cambridge University Press.-
dc.rightsThis article has been published in a revised form in [Journal] [http://doi.org/XXX]. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder.-
dc.titleD.01 Earlier treatment with the Ketogenic Diet improves seizure outcome in early-onset drug-resistant epilepsy-
dc.typeConference_Paper-
dc.identifier.emailIrwin, M: mgirwin@hku.hk-
dc.identifier.authorityIrwin, M=rp00390-
dc.identifier.doi10.1017/cjn.2016.74-
dc.identifier.hkuros300389-
dc.identifier.volume43-
dc.identifier.issueS2-
dc.identifier.spageS13-
dc.identifier.epageS13-
dc.publisher.placeUnited States-

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