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Article: Impact of obesity on longitudinal changes to cardiac structure and function in patients with Type 2 diabetes mellitus

TitleImpact of obesity on longitudinal changes to cardiac structure and function in patients with Type 2 diabetes mellitus
Authors
Keywordsbody mass index
obesity
longitudinal cardiac change
Type 2 diabetes mellitus
Issue Date2019
PublisherOxford University Press. The Journal's web site is located at http://ejechocard.oxfordjournals.org
Citation
European Heart Journal - Cardiovascular Imaging , 2019, v. 20 n. 7, p. 816-827 How to Cite?
AbstractAims: Few prospective studies have evaluated the natural progression of left ventricular (LV) remodelling in patients with Type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the impact of obesity on longitudinal cardiac structural and functional changes in patients with T2DM. Methods and results: This study comprised of 274 patients with T2DM (mean age, 62.2 ± 11.4 years; male, 51.5%). Echocardiographic parameters including LV geometry, systolic, and diastolic functions were measured at baseline and follow-up. The median follow-up was 24 months (from 12 months to 48 months). The entire cohort showed a significant increase in LV wall thickness, LV mass (LVM), and prevalence of concentric hypertrophy (19.6–27.3%). Further, systolic function and diastolic function had deteriorated at follow-up assessment. Multivariable adjusted linear regression demonstrated that baseline body mass index (BMI) predicted longitudinal change to LVM (β  = 0.29, P < 0.01) and LV ejection fraction (β  = −0.15, P < 0.05). Patients were divided into three groups according to their BMI: normal weight (BMI <23 kg/m2), overweight (BMI between 23 kg/m2 and 27.5 kg/m2), or obese (BMI ≥27.5 kg/m2). Importantly, obesity at baseline predicted a greater longitudinal increase in LVM and decrease in LV ejection fraction compared with overweight and normal weight patients. Conclusion: Being obese at baseline was associated with greater longitudinal increase in LV mass and greater deterioration in LV systolic function.
Persistent Identifierhttp://hdl.handle.net/10722/272681
ISSN
2017 Impact Factor: 8.336
2015 SCImago Journal Rankings: 2.044

 

DC FieldValueLanguage
dc.contributor.authorWu, MZ-
dc.contributor.authorChen, Y-
dc.contributor.authorZou, Y-
dc.contributor.authorZhen, Z-
dc.contributor.authorYU, YJ-
dc.contributor.authorLiu, YX-
dc.contributor.authorYuen, M-
dc.contributor.authorHo, LM-
dc.contributor.authorLam, KSL-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.date.accessioned2019-08-06T09:14:33Z-
dc.date.available2019-08-06T09:14:33Z-
dc.date.issued2019-
dc.identifier.citationEuropean Heart Journal - Cardiovascular Imaging , 2019, v. 20 n. 7, p. 816-827-
dc.identifier.issn2047-2404-
dc.identifier.urihttp://hdl.handle.net/10722/272681-
dc.description.abstractAims: Few prospective studies have evaluated the natural progression of left ventricular (LV) remodelling in patients with Type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the impact of obesity on longitudinal cardiac structural and functional changes in patients with T2DM. Methods and results: This study comprised of 274 patients with T2DM (mean age, 62.2 ± 11.4 years; male, 51.5%). Echocardiographic parameters including LV geometry, systolic, and diastolic functions were measured at baseline and follow-up. The median follow-up was 24 months (from 12 months to 48 months). The entire cohort showed a significant increase in LV wall thickness, LV mass (LVM), and prevalence of concentric hypertrophy (19.6–27.3%). Further, systolic function and diastolic function had deteriorated at follow-up assessment. Multivariable adjusted linear regression demonstrated that baseline body mass index (BMI) predicted longitudinal change to LVM (β  = 0.29, P < 0.01) and LV ejection fraction (β  = −0.15, P < 0.05). Patients were divided into three groups according to their BMI: normal weight (BMI <23 kg/m2), overweight (BMI between 23 kg/m2 and 27.5 kg/m2), or obese (BMI ≥27.5 kg/m2). Importantly, obesity at baseline predicted a greater longitudinal increase in LVM and decrease in LV ejection fraction compared with overweight and normal weight patients. Conclusion: Being obese at baseline was associated with greater longitudinal increase in LV mass and greater deterioration in LV systolic function.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://ejechocard.oxfordjournals.org-
dc.relation.ispartofEuropean Heart Journal - Cardiovascular Imaging-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.subjectbody mass index-
dc.subjectobesity-
dc.subjectlongitudinal cardiac change-
dc.subjectType 2 diabetes mellitus-
dc.titleImpact of obesity on longitudinal changes to cardiac structure and function in patients with Type 2 diabetes mellitus-
dc.typeArticle-
dc.identifier.emailWu, MZ: wmz513@hku.hk-
dc.identifier.emailChen, Y: cheny818@hku.hk-
dc.identifier.emailZhen, Z: zhenzhe@hku.hk-
dc.identifier.emailYuen, M: mmayuen@hku.hk-
dc.identifier.emailHo, LM: lmho@hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityHo, LM=rp00360-
dc.identifier.authorityLam, KSL=rp00343-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/ehjci/jey217-
dc.identifier.pmid30629141-
dc.identifier.scopuseid_2-s2.0-85068542052-
dc.identifier.hkuros300744-
dc.identifier.volume20-
dc.identifier.issue7-
dc.identifier.spage816-
dc.identifier.epage827-
dc.publisher.placeUnited Kingdom-

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