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Article: Treatment of late sequelae after radiotherapy for head and neck cancer

TitleTreatment of late sequelae after radiotherapy for head and neck cancer
Authors
KeywordsHead and neck cancer
Radiotherapy
Toxicity
Late sequelae
Treatment
Issue Date2017
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ctrv
Citation
Cancer Treatment Reviews, 2017, v. 59, p. 79-92 How to Cite?
AbstractRadiotherapy (RT) is used to treat approximately 80% of patients with cancer of the head and neck. Despite enormous advances in RT planning and delivery, a significant number of patients will experience radiation-associated toxicities, especially those treated with concurrent systemic agents. Many effective management options are available for acute RT-associated toxicities, but treatment options are much more limited and of variable benefit among patients who develop late sequelae after RT. The adverse impact of developing late tissue damage in irradiated patients may range from bothersome symptoms that negatively affect their quality of life to severe life-threatening complications. In the region of the head and neck, among the most problematic late effects are impaired function of the salivary glands and swallowing apparatus. Other tissues and structures in the region may be at risk, depending mainly on the location of the irradiated tumor relative to the mandible and hearing apparatus. Here, we review the available evidence on the use of different therapeutic strategies to alleviate common late sequelae of RT in head and neck cancer patients, with a focus on the critical assessment of the treatment options for xerostomia, dysphagia, mandibular osteoradionecrosis, trismus, and hearing loss.
Persistent Identifierhttp://hdl.handle.net/10722/272163
ISSN
2017 Impact Factor: 8.122
2015 SCImago Journal Rankings: 3.284
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorStrojan, P-
dc.contributor.authorHutcheson, KA-
dc.contributor.authorEisbruch, A-
dc.contributor.authorBeitler, JJ-
dc.contributor.authorLangendijk, JA-
dc.contributor.authorLee, AWM-
dc.contributor.authorCorry, J-
dc.contributor.authorMendenhall, WM-
dc.contributor.authorSmee, R-
dc.contributor.authorRinaldo, A-
dc.contributor.authorFerlito, A-
dc.date.accessioned2019-07-20T10:36:54Z-
dc.date.available2019-07-20T10:36:54Z-
dc.date.issued2017-
dc.identifier.citationCancer Treatment Reviews, 2017, v. 59, p. 79-92-
dc.identifier.issn0305-7372-
dc.identifier.urihttp://hdl.handle.net/10722/272163-
dc.description.abstractRadiotherapy (RT) is used to treat approximately 80% of patients with cancer of the head and neck. Despite enormous advances in RT planning and delivery, a significant number of patients will experience radiation-associated toxicities, especially those treated with concurrent systemic agents. Many effective management options are available for acute RT-associated toxicities, but treatment options are much more limited and of variable benefit among patients who develop late sequelae after RT. The adverse impact of developing late tissue damage in irradiated patients may range from bothersome symptoms that negatively affect their quality of life to severe life-threatening complications. In the region of the head and neck, among the most problematic late effects are impaired function of the salivary glands and swallowing apparatus. Other tissues and structures in the region may be at risk, depending mainly on the location of the irradiated tumor relative to the mandible and hearing apparatus. Here, we review the available evidence on the use of different therapeutic strategies to alleviate common late sequelae of RT in head and neck cancer patients, with a focus on the critical assessment of the treatment options for xerostomia, dysphagia, mandibular osteoradionecrosis, trismus, and hearing loss.-
dc.languageeng-
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ctrv-
dc.relation.ispartofCancer Treatment Reviews-
dc.subjectHead and neck cancer-
dc.subjectRadiotherapy-
dc.subjectToxicity-
dc.subjectLate sequelae-
dc.subjectTreatment-
dc.titleTreatment of late sequelae after radiotherapy for head and neck cancer-
dc.typeArticle-
dc.identifier.emailLee, AWM: awmlee@hkucc.hku.hk-
dc.identifier.authorityLee, AWM=rp02056-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.ctrv.2017.07.003-
dc.identifier.pmid28759822-
dc.identifier.pmcidPMC5902026-
dc.identifier.scopuseid_2-s2.0-85026430562-
dc.identifier.hkuros299312-
dc.identifier.volume59-
dc.identifier.spage79-
dc.identifier.epage92-
dc.identifier.isiWOS:000410468700008-
dc.publisher.placeUnited Kingdom-
dc.identifier.f1000727857911-

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