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Book Chapter: Epidemiology and population screening

TitleEpidemiology and population screening
Authors
KeywordsDescriptive epidemiology
Environmental risk factors
Nasopharyngeal carcinoma
Population screening
Issue Date2019
PublisherAcademic Press
Citation
Epidemiology and population screening. In Lee, AWM, Lung, ML and Ng, WT (Eds.), Nasopharyngeal carcinoma: From etiology to clinical practice, p. 65-84. London: Academic Press, 2019 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is uncommon with a unique geographical distribution. The age-standardized incidence ranges from below 1 in nonendemic areas to 25+/100,000 person-years in endemic regions, and has decreased without specific primary prevention in the past four decades. We have found that smoking is likely a causal factor, family history of NPC a strong risk factor, while vitamin D and milk consumption, and better socioeconomic status, could be protective. The interaction between genetic factors, Epstein–Barr virus (EBV) infection, and environmental and lifestyle risk factors (classical and novel) warrants further investigation using more vigorous methods. Screening by EBV serological markers and circulating EBV DNA in asymptomatic Chinese men has identified NPC cases at earlier stages and with better survival than a historical cohort in Southern China. Further trials and assessment are needed. International or multicenter collaborations on individual data meta-analysis of case-control and cohort studies are warranted.
Persistent Identifierhttp://hdl.handle.net/10722/271405
ISBN

 

DC FieldValueLanguage
dc.contributor.authorMai, Z-
dc.contributor.authorLin, J-
dc.contributor.authorIp, DKM-
dc.contributor.authorHo, DSY-
dc.contributor.authorChan, YH-
dc.contributor.authorLam, TH-
dc.date.accessioned2019-06-24T01:09:13Z-
dc.date.available2019-06-24T01:09:13Z-
dc.date.issued2019-
dc.identifier.citationEpidemiology and population screening. In Lee, AWM, Lung, ML and Ng, WT (Eds.), Nasopharyngeal carcinoma: From etiology to clinical practice, p. 65-84. London: Academic Press, 2019-
dc.identifier.isbn9780128149362-
dc.identifier.urihttp://hdl.handle.net/10722/271405-
dc.description.abstractNasopharyngeal carcinoma (NPC) is uncommon with a unique geographical distribution. The age-standardized incidence ranges from below 1 in nonendemic areas to 25+/100,000 person-years in endemic regions, and has decreased without specific primary prevention in the past four decades. We have found that smoking is likely a causal factor, family history of NPC a strong risk factor, while vitamin D and milk consumption, and better socioeconomic status, could be protective. The interaction between genetic factors, Epstein–Barr virus (EBV) infection, and environmental and lifestyle risk factors (classical and novel) warrants further investigation using more vigorous methods. Screening by EBV serological markers and circulating EBV DNA in asymptomatic Chinese men has identified NPC cases at earlier stages and with better survival than a historical cohort in Southern China. Further trials and assessment are needed. International or multicenter collaborations on individual data meta-analysis of case-control and cohort studies are warranted.-
dc.languageeng-
dc.publisherAcademic Press-
dc.relation.ispartofNasopharyngeal carcinoma: From etiology to clinical practice-
dc.subjectDescriptive epidemiology-
dc.subjectEnvironmental risk factors-
dc.subjectNasopharyngeal carcinoma-
dc.subjectPopulation screening-
dc.titleEpidemiology and population screening-
dc.typeBook_Chapter-
dc.identifier.emailMai, Z: jimzmmai@hku.hk-
dc.identifier.emailLin, J: kawong2@hku.hk-
dc.identifier.emailIp, DKM: dkmip@hku.hk-
dc.identifier.emailHo, DSY: syho@hku.hk-
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.authorityIp, DKM=rp00256-
dc.identifier.authorityHo, DSY=rp00427-
dc.identifier.authorityLam, TH=rp00326-
dc.identifier.doi10.1016/B978-0-12-814936-2.00004-3-
dc.identifier.hkuros298037-
dc.identifier.spage65-
dc.identifier.epage84-
dc.publisher.placeLondon-

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