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Article: The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma

TitleThe mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma
Authors
Issue Date2019
PublisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
Citation
Blood, 2019, v. 133, p. 962-966 How to Cite?
AbstractThe new recently described provisional lymphoma category Burkitt-like lymphoma with 11q aberration comprises cases similar to Burkitt lymphoma (BL) on morphological, immunophenotypic and gene-expression levels but lacking the IG-MYC translocation. They are characterized by a peculiar imbalance pattern on chromosome 11, but the landscape of mutations is not yet described. Thus, we investigated 15 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL,11q,) cases by copy-number analysis and whole-exome sequencing. We refined the regions of 11q imbalance and identified the INO80 complex-associated gene NFRKB as a positional candidate in 11q24.3. Next to recurrent gains in 12q13.11-q24.32 and 7q34-qter as well as losses in 13q32.3-q34, we identified 47 genes recurrently affected by protein-changing mutations (each ≥3 of 15 cases). Strikingly, we did not detect recurrent mutations in genes of the ID3-TCF3 axis or the SWI/SNF complex that are frequently altered in BL, or in genes frequently mutated in germinal center-derived B-cell lymphomas like KMT2D or CREBBP An exception is GNA13, which was mutated in 7 of 15 cases. We conclude that the genomic landscape of mnBLL,11q, differs from that of BL both at the chromosomal and mutational levels. Our findings implicate that mnBLL,11q, is a lymphoma category distinct from BL at the molecular level.
Persistent Identifierhttp://hdl.handle.net/10722/271317
ISSN
2019 Impact Factor: 17.543
2015 SCImago Journal Rankings: 6.395

 

DC FieldValueLanguage
dc.contributor.authorWagener, R-
dc.contributor.authorSeufert, J-
dc.contributor.authorRaimondi, F-
dc.contributor.authorBens, S-
dc.contributor.authorKleinheinz, K-
dc.contributor.authorNagel, I-
dc.contributor.authorAltmüller, J-
dc.contributor.authorThiele, H-
dc.contributor.authorHübschmann, D-
dc.contributor.authorKohler, CW-
dc.contributor.authorNürnberg, P-
dc.contributor.authorAu-Yeung, R-
dc.contributor.authorBurkhardt, B-
dc.contributor.authorHorn, H-
dc.contributor.authorLeoncini, L-
dc.contributor.authorJaffe, ES-
dc.contributor.authorOtt, G-
dc.contributor.authorRymkiewicz, G-
dc.contributor.authorSchlesner, M-
dc.contributor.authorRussell, RB-
dc.contributor.authorKlapper, W-
dc.contributor.authorSiebert, R-
dc.date.accessioned2019-06-24T01:07:31Z-
dc.date.available2019-06-24T01:07:31Z-
dc.date.issued2019-
dc.identifier.citationBlood, 2019, v. 133, p. 962-966-
dc.identifier.issn0006-4971-
dc.identifier.urihttp://hdl.handle.net/10722/271317-
dc.description.abstractThe new recently described provisional lymphoma category Burkitt-like lymphoma with 11q aberration comprises cases similar to Burkitt lymphoma (BL) on morphological, immunophenotypic and gene-expression levels but lacking the IG-MYC translocation. They are characterized by a peculiar imbalance pattern on chromosome 11, but the landscape of mutations is not yet described. Thus, we investigated 15 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL,11q,) cases by copy-number analysis and whole-exome sequencing. We refined the regions of 11q imbalance and identified the INO80 complex-associated gene NFRKB as a positional candidate in 11q24.3. Next to recurrent gains in 12q13.11-q24.32 and 7q34-qter as well as losses in 13q32.3-q34, we identified 47 genes recurrently affected by protein-changing mutations (each ≥3 of 15 cases). Strikingly, we did not detect recurrent mutations in genes of the ID3-TCF3 axis or the SWI/SNF complex that are frequently altered in BL, or in genes frequently mutated in germinal center-derived B-cell lymphomas like KMT2D or CREBBP An exception is GNA13, which was mutated in 7 of 15 cases. We conclude that the genomic landscape of mnBLL,11q, differs from that of BL both at the chromosomal and mutational levels. Our findings implicate that mnBLL,11q, is a lymphoma category distinct from BL at the molecular level.-
dc.languageeng-
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/-
dc.relation.ispartofBlood-
dc.rightsThis research was originally published in [Journal Title]. Author(s). Title. [Journal Title]. Year;Vol,Issue:pp-pp. © the American Society of Hematology.-
dc.titleThe mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma-
dc.typeArticle-
dc.identifier.emailAu-Yeung, R: rex.auyeung@hku.hk-
dc.identifier.authorityAu-Yeung, R=rp01877-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1182/blood-2018-07-864025-
dc.identifier.scopuseid_2-s2.0-85065105477-
dc.identifier.hkuros298224-
dc.identifier.volume133-
dc.identifier.spage962-
dc.identifier.epage966-
dc.publisher.placeUnited States-

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