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Article: Contrasting Epidemiology and Clinicopathology of Female Breast Cancer in Asians versus the US Population

TitleContrasting Epidemiology and Clinicopathology of Female Breast Cancer in Asians versus the US Population
Authors
Keywordscancer
colorectal cancer
epidemiology
asian americans
estrogen receptors
Issue Date2019
PublisherOxford University Press. The Journal's web site is located at http://jncicancerspectrum.oxfordjournals.org/
Citation
JNCI: Journal of the National Cancer Institute, 2019, Epub, p. article no. djz090 How to Cite?
AbstractBACKGROUND: The incidence of breast cancer among younger East Asian women has been increasing rapidly over recent decades. This international collaborative study systemically compared the differences in age-specific incidences and pathological characteristics of breast cancer in women between East Asian and predominantly European ancestry. METHODS: We excerpted analytic data from six national cancer registries (979,675 cases) and eight hospitals (18,008 cases) in East Asian countries/regions and, for comparisons, from the United States Surveillance, Epidemiology, and End Results (SEER) program database. Linear regression analyses of age-specific incidences of female breast cancer and logistic regression analyses of age-specific pathological characteristics of breast cancer were performed. All statistical tests were two-sided. RESULTS: Unlike female colorectal cancer, the age-specific incidences of breast cancer among East Asian women aged ≤ 59 years increased disproportionally over recent decades relative to rates in United States contemporaries. For years 2010 - 2014, the estimated age-specific probability of estrogen receptor (ER) positivity increased with age in American patients, whereas that of triple negative breast cancer (TNBC) declined with age. No similar trends were evident in East Asian patients: their probability of ER positivity at age 40-49 years was statistically significantly higher (odd ratio [OR] = 1.50, 95% confidence interval [CI]: 1.36-1.67, P < .001) and of TNBC was statistically significantly lower (OR = 0.79, 95% CI: 0.71-0.88, P < .001), whereas the probability of ER positivity at age 50-59 years was statistically significantly lower (OR = 0.88, 95% CI: 0.828-0.95, P < .001). Subgroup analyses of SEER data showed similarly distinct patterns between East Asian American and white American patients. CONCLUSION: Contrasting age-specific incidences and pathological characteristics of breast cancer between East Asian and American women, as well as between East Asian Americans and white Americans, suggests racial differences in the biology.
Persistent Identifierhttp://hdl.handle.net/10722/271313
ISSN
2017 Impact Factor: 11.238
2015 SCImago Journal Rankings: 6.192

 

DC FieldValueLanguage
dc.contributor.authorLin, CH-
dc.contributor.authorYap, YS-
dc.contributor.authorLee, KH-
dc.contributor.authorIm, SA-
dc.contributor.authorNaito, Y-
dc.contributor.authorYeo, W-
dc.contributor.authorUeno, T-
dc.contributor.authorKwong, A-
dc.contributor.authorLi, H-
dc.contributor.authorHuang, SM-
dc.contributor.authorLeung, R-
dc.contributor.authorHan, W-
dc.contributor.authorTan, B-
dc.contributor.authorHu, FC-
dc.contributor.authorHuang, CS-
dc.contributor.authorCheng, AL-
dc.contributor.authorLu, YS-
dc.date.accessioned2019-06-24T01:07:27Z-
dc.date.available2019-06-24T01:07:27Z-
dc.date.issued2019-
dc.identifier.citationJNCI: Journal of the National Cancer Institute, 2019, Epub, p. article no. djz090-
dc.identifier.issn0027-8874-
dc.identifier.urihttp://hdl.handle.net/10722/271313-
dc.description.abstractBACKGROUND: The incidence of breast cancer among younger East Asian women has been increasing rapidly over recent decades. This international collaborative study systemically compared the differences in age-specific incidences and pathological characteristics of breast cancer in women between East Asian and predominantly European ancestry. METHODS: We excerpted analytic data from six national cancer registries (979,675 cases) and eight hospitals (18,008 cases) in East Asian countries/regions and, for comparisons, from the United States Surveillance, Epidemiology, and End Results (SEER) program database. Linear regression analyses of age-specific incidences of female breast cancer and logistic regression analyses of age-specific pathological characteristics of breast cancer were performed. All statistical tests were two-sided. RESULTS: Unlike female colorectal cancer, the age-specific incidences of breast cancer among East Asian women aged ≤ 59 years increased disproportionally over recent decades relative to rates in United States contemporaries. For years 2010 - 2014, the estimated age-specific probability of estrogen receptor (ER) positivity increased with age in American patients, whereas that of triple negative breast cancer (TNBC) declined with age. No similar trends were evident in East Asian patients: their probability of ER positivity at age 40-49 years was statistically significantly higher (odd ratio [OR] = 1.50, 95% confidence interval [CI]: 1.36-1.67, P < .001) and of TNBC was statistically significantly lower (OR = 0.79, 95% CI: 0.71-0.88, P < .001), whereas the probability of ER positivity at age 50-59 years was statistically significantly lower (OR = 0.88, 95% CI: 0.828-0.95, P < .001). Subgroup analyses of SEER data showed similarly distinct patterns between East Asian American and white American patients. CONCLUSION: Contrasting age-specific incidences and pathological characteristics of breast cancer between East Asian and American women, as well as between East Asian Americans and white Americans, suggests racial differences in the biology.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://jncicancerspectrum.oxfordjournals.org/-
dc.relation.ispartofJNCI: Journal of the National Cancer Institute-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.subjectcancer-
dc.subjectcolorectal cancer-
dc.subjectepidemiology-
dc.subjectasian americans-
dc.subjectestrogen receptors-
dc.titleContrasting Epidemiology and Clinicopathology of Female Breast Cancer in Asians versus the US Population-
dc.typeArticle-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityKwong, A=rp01734-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/jnci/djz090-
dc.identifier.hkuros298207-
dc.identifier.spagearticle no. djz090-
dc.identifier.epagearticle no. djz090-
dc.publisher.placeUnited Kingdom-

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