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Article: SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice

TitleSCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice
Authors
Issue Date2019
PublisherOxford University Press (OUP): Policy C - Option B. The Journal's web site is located at http://nar.oxfordjournals.org/
Citation
Nucleic Acids Research, 2019, article no. gkz226 How to Cite?
AbstractMeiosis is a specialized cell division for producing haploid gametes from diploid germ cells. During meiosis, synaptonemal complex (SC) mediates the alignment of homologs and plays essential roles in homologous recombination and therefore in promoting accurate chromosome segregation. In this study, we have identified a novel protein SCRE (synaptonemal complex reinforcing element) as a key molecule in maintaining the integrity of SC during meiosis prophase I in mice. Deletion of Scre (synaptonemal complex reinforcing element) caused germ cell death in both male and female mice, resulting in infertility. Our mechanistic studies showed that the synapses and SCs in Scre knockout mice were unstable due to the lack of the SC reinforcing function of SCRE, which is sparsely localized as discrete foci along the central elements in normal synaptic homologous chromosomes. The lack of Scre leads to meiosis collapse at the late zygotene stage. We further showed that SCRE interacts with synaptonemal complex protein 1 (SYCP1) and synaptonemal complex central element 3 (SYCE3). We conclude that the function of SCRE is to reinforce the integrity of the central elements, thereby stabilizing the SC and ensuring meiotic cell cycle progression. Our study identified SCRE as a novel SC fastener protein that is distinct from other known SC proteins.
Persistent Identifierhttp://hdl.handle.net/10722/269893
ISSN
2017 Impact Factor: 11.561
2015 SCImago Journal Rankings: 7.458

 

DC FieldValueLanguage
dc.contributor.authorLiu, H-
dc.contributor.authorHuang, T-
dc.contributor.authorLi, M-
dc.contributor.authorLi, M-
dc.contributor.authorZhang, C-
dc.contributor.authorJiang, J-
dc.contributor.authorYu, X-
dc.contributor.authorYin, Y-
dc.contributor.authorZhang, F-
dc.contributor.authorLu, G-
dc.contributor.authorLuo, M-
dc.contributor.authorZhang, L-
dc.contributor.authorLi, J-
dc.contributor.authorLiu, K-
dc.contributor.authorChen, Z-
dc.date.accessioned2019-05-14T08:57:16Z-
dc.date.available2019-05-14T08:57:16Z-
dc.date.issued2019-
dc.identifier.citationNucleic Acids Research, 2019, article no. gkz226-
dc.identifier.issn0305-1048-
dc.identifier.urihttp://hdl.handle.net/10722/269893-
dc.description.abstractMeiosis is a specialized cell division for producing haploid gametes from diploid germ cells. During meiosis, synaptonemal complex (SC) mediates the alignment of homologs and plays essential roles in homologous recombination and therefore in promoting accurate chromosome segregation. In this study, we have identified a novel protein SCRE (synaptonemal complex reinforcing element) as a key molecule in maintaining the integrity of SC during meiosis prophase I in mice. Deletion of Scre (synaptonemal complex reinforcing element) caused germ cell death in both male and female mice, resulting in infertility. Our mechanistic studies showed that the synapses and SCs in Scre knockout mice were unstable due to the lack of the SC reinforcing function of SCRE, which is sparsely localized as discrete foci along the central elements in normal synaptic homologous chromosomes. The lack of Scre leads to meiosis collapse at the late zygotene stage. We further showed that SCRE interacts with synaptonemal complex protein 1 (SYCP1) and synaptonemal complex central element 3 (SYCE3). We conclude that the function of SCRE is to reinforce the integrity of the central elements, thereby stabilizing the SC and ensuring meiotic cell cycle progression. Our study identified SCRE as a novel SC fastener protein that is distinct from other known SC proteins.-
dc.languageeng-
dc.publisherOxford University Press (OUP): Policy C - Option B. The Journal's web site is located at http://nar.oxfordjournals.org/-
dc.relation.ispartofNucleic Acids Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice-
dc.typeArticle-
dc.identifier.emailLiu, K: kliugc@hku.hk-
dc.identifier.authorityLiu, K=rp02475-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/nar/gkz226-
dc.identifier.pmid30949703-
dc.identifier.spagearticle no. gkz226-
dc.identifier.epagearticle no. gkz226-
dc.publisher.placeUnited Kingdom-

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