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Article: MicroRNA and Human Bone Health

TitleMicroRNA and Human Bone Health
Authors
Issue Date2019
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2473-4039
Citation
JBMR Plus, 2019, v. 3 n. 1, p. 2-13 How to Cite?
AbstractThe small non-coding microRNAs (miRNAs) are post-transcription regulators that modulate diverse cellular process in bone cells. Because optimal miRNA targeting is essential for their function, single-nucleotide polymorphisms (SNPs) within or proximal to the loci of miRNA (miR-SNPs) or mRNA (PolymiRTS) could potentially disrupt the miRNA-mRNA interaction, leading to changes in bone metabolism and osteoporosis. Recent human studies of skeletal traits using miRNA profiling, genomewide association studies, and functional studies started to decipher the complex miRNA regulatory network. These studies have indicated that miRNAs may be a promising bone marker. This review focuses on human miRNA studies on bone traits and discusses how genetic variants affect bone metabolic pathways. Major ex vivo investigations using human samples supported with animal and in vitro models have shed light on the mechanistic role of miRNAs. Furthermore, studying the miRNAs' signatures in secondary osteoporosis and osteoporotic medications such as teriparatide (TPTD) and denosumab (DMab) have provided valuable insight into clinical management of the disease. (c) 2018 The Authors. JBMR Plus Published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.
Persistent Identifierhttp://hdl.handle.net/10722/269434
ISSN
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, VK-
dc.contributor.authorAu, CM-
dc.contributor.authorTan, KCB-
dc.contributor.authorCheung, CL-
dc.date.accessioned2019-04-24T08:07:38Z-
dc.date.available2019-04-24T08:07:38Z-
dc.date.issued2019-
dc.identifier.citationJBMR Plus, 2019, v. 3 n. 1, p. 2-13-
dc.identifier.issn2473-4039-
dc.identifier.urihttp://hdl.handle.net/10722/269434-
dc.description.abstractThe small non-coding microRNAs (miRNAs) are post-transcription regulators that modulate diverse cellular process in bone cells. Because optimal miRNA targeting is essential for their function, single-nucleotide polymorphisms (SNPs) within or proximal to the loci of miRNA (miR-SNPs) or mRNA (PolymiRTS) could potentially disrupt the miRNA-mRNA interaction, leading to changes in bone metabolism and osteoporosis. Recent human studies of skeletal traits using miRNA profiling, genomewide association studies, and functional studies started to decipher the complex miRNA regulatory network. These studies have indicated that miRNAs may be a promising bone marker. This review focuses on human miRNA studies on bone traits and discusses how genetic variants affect bone metabolic pathways. Major ex vivo investigations using human samples supported with animal and in vitro models have shed light on the mechanistic role of miRNAs. Furthermore, studying the miRNAs' signatures in secondary osteoporosis and osteoporotic medications such as teriparatide (TPTD) and denosumab (DMab) have provided valuable insight into clinical management of the disease. (c) 2018 The Authors. JBMR Plus Published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2473-4039-
dc.relation.ispartofJBMR Plus-
dc.rightsThis is the peer reviewed version of the following article: [JBMR Plus, 2019, v. 3 n. 1, p. 2-13], which has been published in final form at [10.1002/jbm4.10115]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleMicroRNA and Human Bone Health-
dc.typeArticle-
dc.identifier.emailAu, CM: philipa@hku.hk-
dc.identifier.emailTan, KCB: kcbtan@hkucc.hku.hk-
dc.identifier.emailCheung, CL: lung1212@hku.hk-
dc.identifier.authorityTan, KCB=rp00402-
dc.identifier.authorityCheung, CL=rp01749-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/jbm4.10115-
dc.identifier.pmcidPMC6339549-
dc.identifier.hkuros297360-
dc.identifier.volume3-
dc.identifier.issue1-
dc.identifier.spage2-
dc.identifier.epage13-
dc.publisher.placeUnited States-

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