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Article: Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin

TitleUniversal protection against influenza infection by a multidomain antibody to influenza hemagglutinin
Authors
Issue Date2018
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 2018, v. 362 n. 6414, p. 598-602 How to Cite?
AbstractBroadly neutralizing antibodies against highly variable pathogens have stimulated the design of vaccines and therapeutics. We report the use of diverse camelid single-domain antibodies to influenza virus hemagglutinin to generate multidomain antibodies with impressive breadth and potency. Multidomain antibody MD3606 protects mice against influenza A and B infection when administered intravenously or expressed locally from a recombinant adeno-associated virus vector. Crystal and single-particle electron microscopy structures of these antibodies with hemagglutinins from influenza A and B viruses reveal binding to highly conserved epitopes. Collectively, our findings demonstrate that multidomain antibodies targeting multiple epitopes exhibit enhanced virus cross-reactivity and potency. In combination with adeno-associated virus-mediated gene delivery, they may provide an effective strategy to prevent infection with influenza virus and other highly variable pathogens.
Persistent Identifierhttp://hdl.handle.net/10722/268303
ISSN
2017 Impact Factor: 41.058
2015 SCImago Journal Rankings: 13.217
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLaursen, NS-
dc.contributor.authorFriesen, RHE-
dc.contributor.authorZhu, X-
dc.contributor.authorJongeneelen, M-
dc.contributor.authorBlokland, S-
dc.contributor.authorVermond, J-
dc.contributor.authorvan Eijgen, A-
dc.contributor.authorTang, C-
dc.contributor.authorvan Diepen, H-
dc.contributor.authorObmolova, G-
dc.contributor.authorvan der Neut Kolfschoten, M-
dc.contributor.authorZuijdgeest, D-
dc.contributor.authorStraetemans, R-
dc.contributor.authorHoffman, RMB-
dc.contributor.authorNieusma, T-
dc.contributor.authorPallesen, J-
dc.contributor.authorTurner, HL-
dc.contributor.authorBernard, SM-
dc.contributor.authorWard, AB-
dc.contributor.authorLuo, J-
dc.contributor.authorPoon, LML-
dc.contributor.authorTretiakova, AP-
dc.contributor.authorWilson, JM-
dc.contributor.authorLimberis, MP-
dc.contributor.authorVogels, R-
dc.contributor.authorBrandenburg, B-
dc.contributor.authorKolkman, JA-
dc.contributor.authorWilson, IA-
dc.date.accessioned2019-03-18T04:22:49Z-
dc.date.available2019-03-18T04:22:49Z-
dc.date.issued2018-
dc.identifier.citationScience, 2018, v. 362 n. 6414, p. 598-602-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/268303-
dc.description.abstractBroadly neutralizing antibodies against highly variable pathogens have stimulated the design of vaccines and therapeutics. We report the use of diverse camelid single-domain antibodies to influenza virus hemagglutinin to generate multidomain antibodies with impressive breadth and potency. Multidomain antibody MD3606 protects mice against influenza A and B infection when administered intravenously or expressed locally from a recombinant adeno-associated virus vector. Crystal and single-particle electron microscopy structures of these antibodies with hemagglutinins from influenza A and B viruses reveal binding to highly conserved epitopes. Collectively, our findings demonstrate that multidomain antibodies targeting multiple epitopes exhibit enhanced virus cross-reactivity and potency. In combination with adeno-associated virus-mediated gene delivery, they may provide an effective strategy to prevent infection with influenza virus and other highly variable pathogens.-
dc.languageeng-
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org-
dc.relation.ispartofScience-
dc.rightsScience. Copyright © American Association for the Advancement of Science.-
dc.rightsThis is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in [Science Journal Title] on [Volume number and date], DOI: [insert DOI number].-
dc.titleUniversal protection against influenza infection by a multidomain antibody to influenza hemagglutinin-
dc.typeArticle-
dc.identifier.emailPoon, LML: llmpoon@hkucc.hku.hk-
dc.identifier.authorityPoon, LML=rp00484-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1126/science.aaq0620-
dc.identifier.pmcidPMC6241527-
dc.identifier.hkuros297098-
dc.identifier.volume362-
dc.identifier.issue6414-
dc.identifier.spage598-
dc.identifier.epage602-
dc.publisher.placeUnited States-
dc.identifier.f1000734323560-

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