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Article: Changes in functional lung regions during the course of radiation therapy and their potential impact on lung dosimetry for non-small cell lung cancer

TitleChanges in functional lung regions during the course of radiation therapy and their potential impact on lung dosimetry for non-small cell lung cancer
Authors
Issue Date2014
Citation
International Journal of Radiation Oncology Biology Physics, 2014, v. 89, n. 1, p. 145-151 How to Cite?
AbstractPurpose To study changes in functional activity on ventilation (V)/perfusion (Q) single-photon emission computed tomography (SPECT) during radiation therapy (RT) and explore the impact of such changes on lung dosimetry in patients with non-small cell lung cancer (NSCLC). Methods and Materials Fifteen NSCLC patients with centrally located tumors were enrolled. All patients were treated with definitive RT dose of ≥60 Gy. V/Q SPECT-CT scans were performed prior to and after delivery of 45 Gy of fractionated RT. SPECT images were used to define temporarily dysfunctional regions of lung caused by tumor or other potentially reversible conditions as B3. The functional lung (FL) was defined on SPECT by 2 separate approaches: FL1, a threshold of 30% of the maximum uptake of the patient's lung; and FL2, FL1 plus B3 region. The impact of changes in FL between initiation of RT and delivery of 45 Gy on lung dosimetry were analyzed. Results Fourteen patients (93%) had larger FL2 volumes than FL1 pre-RT (P<.001). Dysfunctional lung became functional in 11 patients (73%) on V SPECT and in 10 patients (67%) on Q SPECT. The dosimetric parameters generated from CT-based anatomical lung had significantly lower values in FL1 than FL2, with a median reduction in the volume of lung receiving a dose of at least 20 Gy (V20) of 3%, 5.6%, and mean lung dose of 0.95 and 1.55 on V and Q SPECT respectively. Conclusions Regional ventilation and perfusion function improve significantly during RT in centrally located NSCLC. Lung dosimetry values vary notably between different definitions of functional lung. © 2014 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/266978
ISSN
2017 Impact Factor: 5.554
2015 SCImago Journal Rankings: 2.274
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMeng, Xue-
dc.contributor.authorFrey, Kirk-
dc.contributor.authorMatuszak, Martha-
dc.contributor.authorPaul, Stanton-
dc.contributor.authorTen Haken, Randall-
dc.contributor.authorYu, Jinming-
dc.contributor.authorKong, Feng Ming-
dc.date.accessioned2019-01-31T07:20:09Z-
dc.date.available2019-01-31T07:20:09Z-
dc.date.issued2014-
dc.identifier.citationInternational Journal of Radiation Oncology Biology Physics, 2014, v. 89, n. 1, p. 145-151-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/266978-
dc.description.abstractPurpose To study changes in functional activity on ventilation (V)/perfusion (Q) single-photon emission computed tomography (SPECT) during radiation therapy (RT) and explore the impact of such changes on lung dosimetry in patients with non-small cell lung cancer (NSCLC). Methods and Materials Fifteen NSCLC patients with centrally located tumors were enrolled. All patients were treated with definitive RT dose of ≥60 Gy. V/Q SPECT-CT scans were performed prior to and after delivery of 45 Gy of fractionated RT. SPECT images were used to define temporarily dysfunctional regions of lung caused by tumor or other potentially reversible conditions as B3. The functional lung (FL) was defined on SPECT by 2 separate approaches: FL1, a threshold of 30% of the maximum uptake of the patient's lung; and FL2, FL1 plus B3 region. The impact of changes in FL between initiation of RT and delivery of 45 Gy on lung dosimetry were analyzed. Results Fourteen patients (93%) had larger FL2 volumes than FL1 pre-RT (P<.001). Dysfunctional lung became functional in 11 patients (73%) on V SPECT and in 10 patients (67%) on Q SPECT. The dosimetric parameters generated from CT-based anatomical lung had significantly lower values in FL1 than FL2, with a median reduction in the volume of lung receiving a dose of at least 20 Gy (V20) of 3%, 5.6%, and mean lung dose of 0.95 and 1.55 on V and Q SPECT respectively. Conclusions Regional ventilation and perfusion function improve significantly during RT in centrally located NSCLC. Lung dosimetry values vary notably between different definitions of functional lung. © 2014 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physics-
dc.titleChanges in functional lung regions during the course of radiation therapy and their potential impact on lung dosimetry for non-small cell lung cancer-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2014.01.044-
dc.identifier.pmid24725697-
dc.identifier.scopuseid_2-s2.0-84898659418-
dc.identifier.volume89-
dc.identifier.issue1-
dc.identifier.spage145-
dc.identifier.epage151-
dc.identifier.eissn1879-355X-
dc.identifier.isiWOS:000334590500021-

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