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Article: Indirubin-3’-oxime as an antiviral and immunomodulatory agent in treatment of severe human influenza virus infection

TitleIndirubin-3’-oxime as an antiviral and immunomodulatory agent in treatment of severe human influenza virus infection
Authors
Issue Date2018
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
Hong Kong Medical Journal, 2018, v. 24 n. 5, suppl 6, p. 45-47 How to Cite?
香港醫學雜誌, 2018, v. 24 n. 5, suppl 6, p. 45-47 How to Cite?
Abstract1. Two indirubin derivatives (indirubin-3′-oxime and E804) demonstrate strong antiviral and immunomodulatory effects on human macrophages and type-I alveolar epithelial cells after influenza H5N1 virus infection. 2. In mice infected with H5N1 virus, the use of E804 does not improve survival or weight loss but significantly reduces cytokine and chemokine expression and secretion, compared with controls. 3. Cyclin-dependent kinases pathway is involved in the antiviral and immunomodulatory effects of indirubin upon influenza H5N1 virus infection.
DescriptionResearch Fund for the Control of Infectious Diseases project number: 11100972
Persistent Identifierhttp://hdl.handle.net/10722/265961
ISSN
2017 Impact Factor: 1.226
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChan, MCW-
dc.contributor.authorChan, RW-
dc.contributor.authorMok, KP-
dc.contributor.authorMak, NK-
dc.contributor.authorWong, RN-
dc.date.accessioned2018-12-17T02:16:23Z-
dc.date.available2018-12-17T02:16:23Z-
dc.date.issued2018-
dc.identifier.citationHong Kong Medical Journal, 2018, v. 24 n. 5, suppl 6, p. 45-47-
dc.identifier.citation香港醫學雜誌, 2018, v. 24 n. 5, suppl 6, p. 45-47-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/265961-
dc.descriptionResearch Fund for the Control of Infectious Diseases project number: 11100972-
dc.description.abstract1. Two indirubin derivatives (indirubin-3′-oxime and E804) demonstrate strong antiviral and immunomodulatory effects on human macrophages and type-I alveolar epithelial cells after influenza H5N1 virus infection. 2. In mice infected with H5N1 virus, the use of E804 does not improve survival or weight loss but significantly reduces cytokine and chemokine expression and secretion, compared with controls. 3. Cyclin-dependent kinases pathway is involved in the antiviral and immunomodulatory effects of indirubin upon influenza H5N1 virus infection.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.relation.ispartof香港醫學雜誌-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleIndirubin-3’-oxime as an antiviral and immunomodulatory agent in treatment of severe human influenza virus infection-
dc.typeArticle-
dc.identifier.emailChan, MCW: mchan@hku.hk-
dc.identifier.emailMok, KP: ch02mkp@hkucc.hku.hk-
dc.identifier.authorityChan, MCW=rp00420-
dc.identifier.authorityMok, KP=rp01805-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid30229739-
dc.identifier.hkuros296396-
dc.identifier.volume24-
dc.identifier.issue5, suppl 6-
dc.identifier.spage45-
dc.identifier.epage47-
dc.publisher.placeHong Kong-

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